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The Big & Dandy Medication/Supplement Interaction Thread

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To start with, I had fasted since 8:30am to prepare myself for the voyage. IMy pal had gotten some St. John's Wort from a local store.

At 6:30pm we took 3g of the wort (mild MAOI) and let it settle for 30 minutes, at 7:00 we took the cubensis stems and chopped it fine enough to go into a single piece of bread with a thin layer of peanut butter on it. The caps, we simply slapped some peanut butter on it with a small piece of bittersweet chocolate and munched away. All total, it was 2.5g of dried cubensis each. Washed down with a cup of orange juice, all was well and taste was a non-issue.

At T+30 mins, a warmth was felt from within, and colors were getting more vivid....the mind was changing. At T+1:00, visuals were starting to get active, colors were almost flourescent, and we watched the sunset, and the clouds with the orange hue and blue background were something from a dream.

By the time we hit T+1:30, full blown travels were in effect =D At T+2:00 we were peaked hard core, and things were not the same. Faces morphed from one second to the next....the carpet became a plasma ocean...things would merge into one another, then come back, then shift into another shape or form. Playing a video game was almost impossible, as the screen would morph, the TV looked like it was part of the wall and the images were a window to another world. This peak lasted right at 3 hours, amazing!!!!

We took a swim in the pool at the peak as well, and that was something out of this world. We floated with closed eyes, and the most rich organic patterns of moving lights and capillaries presented themselves, and I had the feeling of some other presence in my head, like I was being communicated with, not with voice but with lights and patterns, almost like an incredibly detailed Mayan art form. It was like floating in the Void, with no body, only Mind.

I listened to some music on my headphones/mp3 player, some Delerium, and I was in utter bliss, utter lack of ego, and reduced to some basic form, as I could hardly understand words, but I knew what it was about. Life, Love, Compassion, and a lack of violence.

After coming down, I laid and integrated some of the events as best I could, and finally drifted off to slumber sometime fter 1:30am.

So all in all, I had an incredible 5 hour experience, one I wish to repeat soon. If some of the people in the world could see what I saw, could feel what I felt, the world would become better for it.

Thanks for the advice folks. I do not think I will ever bother with rolls again, there is no need, and it is vastly inferior to the organic travels I undertook. A level 4 voyage into another world. Next time, 3g of cubes is lined up.
 
Youkai said:
I still dont quite udnerstand how MAOinhibination actualy changes the trip (physicaly.. science of it)

care to explain? I know it stops enzymes in the liver from breaking down monoamines... but what does that equate to in experiene?

The reason that it increases the intensity of the trip over what you would get from eating the psychedelics alone is that psychedelics are substrates for MAO. MAO is present in the gut, liver, and brain. Orally administered MAOIs are probably acting primarily by inhibiting MAO in the gut. Under conditions of MAO inhibition, degradation of the psychedelics into non-psychoactive metabolites is greatly impaired, so much more of the active chemical makes it to the receptors in your brain before it is degraded.

I am not sure why MAO inhibition causes qualitative changes in the trip. From a superficial pharmacological standpoint one would expect it to only change the intensity, but in my personal experience, MAO inhibition definitely shifts the headspace in other ways too.
 
Youkai said:
I still dont quite udnerstand how MAOinhibination actualy changes the trip (physicaly.. science of it)

care to explain? I know it stops enzymes in the liver from breaking down monoamines... but what does that equate to in experiene?

Besides helping block the chemical MAO that destroys tryptamines, it also opens up more serotonin receptor sites, as I understand, and allows more of the "good stuff" to lock into those sites.

I don't know how much it helped...but it did not hurt the voyage.
 
5-HT2 said:
The reason that it increases the intensity of the trip over what you would get from eating the psychedelics alone is that psychedelics are substrates for MAO. MAO is present in the gut, liver, and brain. Orally administered MAOIs are probably acting primarily by inhibiting MAO in the gut. Under conditions of MAO inhibition, degradation of the psychedelics into non-psychoactive metabolites is greatly impaired, so more of the active chemical makes it to the receptors in your brain.

I am not sure why MAO inhibition causes qualitative changes in the trip. From a superficial pharmacological standpoint one would expect it to only change the intensity, but in my personal experience, MAO inhibition definitely shifts the headspace in other ways too.
same with me, I always tell people that basicly it allows more of the substance to enter in to the targeted recpetors allowing fro a more intence experience. but it DOES change the experience in just about every way. also it doesnt explain why it is psychedelic on its own. I personaly dont get anything mroe then a minor sedative/anti depressent effects. but I have a friend who get HUGE trails from taking it alone.

Maybe, (though I dont believe it to be the sole reason... if one at all) is that the non-psychoactive metabolites actualy do play a role in the experience alone, if ever so slightly in the highten awareness of the psychedelic condition you "notice" it more... dont know realy. which is why I stoped my maoi use. been tehre done that, Id rather smoke DMT anyways and Iv experienced all that tehre is with LSD and other lysergic acids in combination with maoi's as well as with mushrooms. Still, they were all relitively good experience and I gained something from all of them.
 
I think mao helped man i dont think we could have triped as hard as we did on 2-3 grams if we hadnt taken mao but im also a newb to shrooms ha!!
 
Well, depending on your inhibitor, it can definitely change the subjective effects way outside the realm of simple potentiation.

the commonly used beta-carbolines are psychoactive on their own. As anyone who has ever taken a psychoactive dose of harmaline will tell you (especially if it was more than a threshold dose), the visual effects can be extremely intense.

I can't imagine stronger trails.
 
Well i will say that these visuals were real intense very over welming at points it was me that tripped with therapture What up RAPTURE
 
MAOI safe after stopping with SSRI?

I have just stopped taking Paxil (an SSRI). How long will it take before I can safely take an MAOI again?
 
i took 150mg wellbutrin at 11am and then ~300mg DXM around 10pm and puked, got extremely hot and have felt horrible, nauseous, no appetite, and just tired/sick for the past two days.

horrible combination, however my friend did the same combination and didn't have any problems.

i did take tramadol two days prior to taking the DXM (50mg tramadol) but i was told on BL that would be out of my system, so i'm assuming its the wellbutrin + DXM combo that is bad.
 
The Wellbutrin sounds like it could have been likely for making the effects create a medical-level unpleasant situation... but all the negative symptoms you described... vomiting, headache, uncomfortable body buzz, 12 hour trip, and 3 day hangover... are within the range of reactions that could occur anyway with a 700mg dose of DXM. The body feeling is described alternately as bliss or sickness depending on one's tastes and it's possible you just don't like the feeling of moderately strong dissociative experiences. But I'm sure the Wellbutrin didn't help. Sorry your plans went so far awry.
 
Yohimbe plus L sounds like it could be pretty dangerous since even Yohimbe alone can raise blood pressure and pulse a lot...

I tried Syrian Rue before tripping on Woodrose seeds on 3 different occasions. The first time I tried the combo it was with some particularly strong Madagascar HBW (Hawaiian Baby Woodrose) seeds. The Rue def. potentiated the hell out of the seeds. I felt much more intoxicated and spaced out and stoned. The trip was more visual and mentally confusing. I wouldn't have wanted to be in public on it whereas on HBW alone it's very easy to function in public.

The second time I used Rue with Woodrose was from a batch of HBW that came from Hawaiia and I was with my girlfriend and she gave me massages and we fooled around, etc. I found my sense of touch greatly enhanced. It was a very sensual trip, extremely euphoric. This time the combination was clearer and easy to function on (though this may have been because at this point I had a lot more experience under my belt with HBW).

A lot more recently I preloaded on Rue before a Woodrose trip and didn't notice a potentiation at all. In fact, the trip never got intense or insightful and I was very, very nauseous for the first few hours. The Rue made the trip feel lazier and more toxic this time.

So now I don't know what to make of the combo. No idea why my third time combining the two drugs was so different than the first two times. I know the batch of Woodrose I took the third time I combined with Rue were good seeds as I'd previously tried them alone a few times. Maybe my third trip on the combo wasn't that good just because I'd built up such a high tolerance to HBW? I've used it over 20 times in the last 10 months or so.

If you guys can get your hands on them good Madagasar seeds are superior to good Hawaiian ones. More mushroom-like.
 
But A. Nervosa isn't native to Madagascar. I'd be very curious to know what species it is...perhaps there are other Argyrea sp. that are very potent. The HBWR is without a doubt, the most potent natural psychedelic known (leaving out S. Divinorum.) A half-gram is more than enough for full effects.
 
I was wondering what kind of effects I would experience if I took deprenyl on a Tuesday and tripped on acid that Saturday?

Will I experience anything dangerous cardiovascularly, or will it just boost my trip?
 
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