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The Big & Dandy Medication/Supplement Interaction Thread

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Seeing as how Wellbutrin is both a Noradenaline and Dopamine re-uptake inhibitor, and DXM is a Dopamine and Serotonine re-uptake inhibitor.. I'd have to say it is very possible and highly likely Wellbutrin caused your negative side effects. Be happy Wellbutrin doesn't inhibit the re-uptake of Serotonin, as your experience could have been much much worse.

EDIT: Wellbutrin does seem to mildly inhibit Serotonin re-uptake, though not through re-uptake pump inhibition.
 
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I think at one point i was really close to having a seziure that night. i was in my girlfriend's car and i was shaking pretty hard uncontollably. It felt like extreme shivering but it wasnt cold. scary stuff... im not gonna mess with DXM anymore.
Yea im guessing i would have been screwed if i was on an SSRI, serotonin syndrome doesnt sound like much fun. :\
 
haha fastandbulbous.. did u get that from captain beefheart. thats the funniest stuff i've ever heard
 
Is this a potential problem with mixing fluoxetine and DXM as well? Erowid says any SSRI with DMX is bad...
 
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Fluoxetine is a CYP2D6 liver enzyme INHIBITOR, and DXM is metabolised by CYP2D6. So, unless you want to trip for 20 hours off only 90mg or so, I'd say it's not so good.

It's not that your liver can't handle the inhibitor and the DXM at the same time, but your brain would likely show some not so happy symptoms after dexing that long.

Plus, even if the SSRI doens't inhibitor the liver enzyme with breaks down DXM. DXM still causes the release of serotonin, plus that of the SSRI.. yeah. Serotonin syndrome is said to REALLY suck. :\
 
my gf tried it @ 150mg wellbutrin (i think) and 350mg dxm hbr. she overheated and then slept for 48hrs straight w a hangover from hell upon waking.
 
Bummer.. yea i think its obvious now that DXM and wellbutrin definitely dont mix. Im sure it doesnt affect the trip much more than making a few physical side effects more unpleasant. However, the hangover is fukcing obnoxious. Just not worth it... :\
 
fascinating MAOI article, serotonin antagonist potentiation

http://www.maps.org/news-letters/v06n3/06332ott.html

This article really changed everything I thought I knew about MAOIs

From what I gather it seems MAOIs are a double edged sword for DMT they preserve the chemical long enough for it to it to be absorbed, but they also decrease DMTs effects by raising the brains serotonin level. The question I came to after reading this article is; can I combined DMT with an MAOI and a serotonin antagonist? That would seem to be the ultimate auyasca.
So if this article is correct MAOIs have no use potentiating any psychedelic drugs besides DMT and DPT, although I'm sure we have all heard anecdotal evidence of the opposite.
Has anyone here experimented with any of the serotonin antagonists mentioned in the article or elseware? Are there herbal serotonin agonists? What if one were to take DMT the day after MDMA while their serotonin levels were depleted, it seems this could greatly potentate the effect. Do depressed people trip harder off of tryptamines?
What do you all think????
 
Well, any serotonin antagonist would behind to the receptor sites necessary for DMT. I am not sure as to the selectivity of serotonin receptors, but it seems to me that DMT binds with greater affinity than 5HT, otherwise it wouldn't have all of the fun qualities that we know and love. Then again, there are other people on this site far more qualified to answer the question.
 
panic_the_digital said:
Well, any serotonin antagonist would behind to the receptor sites necessary for DMT. I am not sure as to the selectivity of serotonin receptors, but it seems to me that DMT binds with greater affinity than 5HT, otherwise it wouldn't have all of the fun qualities that we know and love. Then again, there are other people on this site far more qualified to answer the question.
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yes what you say sounds correct, but how could a 5HT antagonist block the receptor from DMT but also potentiate DMT, this seems strange. Do both DMT and 5HT bind to the same site, or does dmt bind to other receptors? aslo i just read this article that says the complete opposite from the one in my post:

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2505289&dopt=Abstract

"these studies imply that treatment with 5-HT2 receptor antagonists may be effective in reversing the hallucinogenic effects caused by the ingestion of LSD and LSD-like drugs."

WHAT?
 
i know can someone explain this to me please!
MAPS is supposed to be totally legit
but everything in that article contradicts other scientific articles i have read
also out of the two antagonists they used one was hallucinogenic
and the other seems to be an agonist -- is it possible they made such an enormous mistake!?
 
More then once I ahve used maoi-a/b to potentiate LSD, but maybe it didnt realy potentiate it but it sure as hell made a normal dose alot more intence/longer lasting, it also brought about a whole new beast, it wasnt so much like LSD... realy I ahve yet to experience anything like this befor/after in any of my psychedelic experiences. it was very visual in terms of geometric patterns and had an over all much deeper "self on self" type feel. My thoughts seemed to disect them selves over and over again into oblivion, and I could truely think in my thought, I dont know hwo to explain it, but it DEFFINATELY does something to LSD which isnt decreasing AT ALL in effects.


Im also in beliefe that reading into these type of things will just destroy the actual reality of it, who knows? maybe the energy/vibrations of the molecules plays a bigger role in it then the actual pharmacology of what is taking place.

maoi's also seem to potentiate the effects hbrw seeds in my experience.


take this for instance, the psychedelic effects of say DMT is believed to have something to do with it being an 5ht a2 antagonist, but HOW does this happen? tell me that, tell me why this "action" causes the reaction we experience.


science IMO is useful to an extent, but reading into to much and it just doesnt add up, pieces of the puzzle are always going to be missing and you'll never get the whole picture.[edit] more so then ever when putting science to the self!
 
take this for instance, the psychedelic effects of say DMT is believed to have something to do with it being an 5ht a2 antagonist, but HOW does this happen? tell me that, tell me why this "action" causes the reaction we experience.
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http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?CMD=search&DB=pubmed

Hallucinogens recruit specific cortical 5-HT(2A) receptor-mediated signaling pathways to affect behavior.

Gonzalez-Maeso J, et al.

Department of Neurology, Mount Sinai School of Medicine, New York, NY 10029, USA.

Hallucinogens, including mescaline, psilocybin, and lysergic acid diethylamide (LSD), profoundly affect perception, cognition, and mood. All known drugs of this class are 5-HT(2A) receptor (2AR) agonists, yet closely related 2AR agonists such as lisuride lack comparable psychoactive properties. Why only certain 2AR agonists are hallucinogens and which neural circuits mediate their effects are poorly understood. By genetically expressing 2AR only in cortex, we show that 2AR-regulated pathways on cortical neurons are sufficient to mediate the signaling pattern and behavioral response to hallucinogens. Hallucinogenic and nonhallucinogenic 2AR agonists both regulate signaling in the same 2AR-expressing cortical neurons. However, the signaling and behavioral responses to the hallucinogens are distinct. While lisuride and LSD both act at 2AR expressed by cortex neurons to regulate phospholipase C, LSD responses also involve pertussis toxin-sensitive heterotrimeric G(i/o) proteins and Src. These studies identify the long-elusive neural and signaling mechanisms responsible for the unique effects of hallucinogens.
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I've read through about half the study and its pretty awesome.
 
CretiNation said:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?CMD=search&DB=pubmed



I've read through about half the study and its pretty awesome.
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yeah, that doesnt say shit about how it happends, where is this information coming from? hell where is any information comingf rom when you are "sober". Basicly all that says is that we are just fucking complex computers which can be tweaked to take in alternate information, fuck that.


it still doesnt explain why. It just explains what happends. that actual actions taking place.
 
Youkai said:
Basicly all that says is that we are just fucking complex computers which can be tweaked to take in alternate information
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^^^^^^
sounds about right to me! hallucinogens may induce mystical experiances but the science behind them cant be mystical. its best not to write things off because they are confuseing, especially when there are so many people on this forum who most likely have the awnser!!!

but back to my origonal question can anyone explain that MAPS article and how it seems factually incorrect?? I was on the verge of buying some moclobemide, and then that article had to throw a wrench in my gears. to the person who poseted a little ways back who decribed the effects of MAOI on LSD did it decrease the color as the article stated??

what about serotonin antagonists has anybody successfully used them to potentiate psychedelics???
 
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hamhurricane said:
^^^^^^
sounds about right to me! hallucinogens may induce mystical experiances but the science behind them cant be mystical. its best not to write things off because they are confuseing, especially when there are so many people on this forum who most likely have the awnser!!!

but back to my origonal question can anyone explain that MAPS article and how it seems factually incorrect?? I was on the verge of buying some moclobemide, and then that article had to throw a wrench in my gears. to the person who poseted a little ways back who decribed the effects of MAOI on LSD did it decrease the color as the article stated??

what about serotonin antagonists has anybody successfully used them to potentiate psychedelics???
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It was me who wrote about my LSD/Maoi experiences, and yes and no, it realy changed the whole character of LSD, it was so much of the fluid visuals you get from LSd but much more geometrical transparant rainbow colored patterns on everything, and they were destinkful for differnt thing, a abd of seed would have the same size/pattern reagaurdles hwat it was put against and what it was put against would have a differnt pattern but would remain the same regaurdless what was put against it.

realy, its kinda like DMT (not so much in experience) but in that you jst have to experience it to know what Im talking about.
 
I have been preaching this for a while, and I have started threads on it before. Ill try and find the article. From what I understand, MAOIs only do anything to

Non substututed N,N Dialkylated Tryptamines.
 
Beenhead said:
I have been preaching this for a while, and I have started threads on it before. Ill try and find the article. From what I understand, MAOIs only do anything to

Non substututed N,N Dialkylated Tryptamines.
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have you ever taken some maoi's befor taking LSD?
 
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