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The Big & Dandy Medication/Supplement Interaction Thread

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I'd think this could be dangerous. No particular reason why, other than it is a big unknown. I'm aware they are both cathinone analogues, but they work by very different means.

I'd advise you not to, but if you must, please start off very low. Maybe even a 10mg test dose.
 
my SSRIs are starting to kick in and i can tell by the changes in my thought processes that it would make something like acid alot more intense but probably more enjoyable, id try it, but im also feeling lazy, with how stimulating ecstasy is i thought i would be upity, but i feel tired, probably because im sick
 
Hmm, I've tripped on most common psychocatives whilst being on prozac- DMT, salvia, mushrooms (psilocybe), lots of LSD, 2c-i and found the effects weren't particualrly dimisnhed, just had a different nature. Panicky sensations were decreased, though I didn't think euphoria was. I always consume a lot of drug when I do, so I didn't notice that my trips were any less intense or hallucinogenic then pre-Prozac trips.

Honestly, you should have researched this- one of the first things I did when I was first prescribed SSRI's was look at interactions with illegal drugs. This was for safety, desire to not worsen my condition (extreme anxiety) and because I didn't want to pump my head full of something that would have no effect. That way, I knew to expect a slightly different response from LSD and no effects from e, so I haven't touched that crap in years.

Oh yeah, combing DXM with SSRI's is potentially deadly. Research seratonin syndrome. Bad stuff
 
thank you all for the replies, it is not me that is on the wellbutrin but a friend and I would never give anyone anything that I thought would hurt them so I will tell her it is not a good idea.
 
Wellbutrin is known to lower the seizure threshold. It is thought that it may have played a role in one of the 5-MeO-AMT fatalities. If one is on Wellbutrin one should probably avoid taking any drugs that might have the potential for stimulation and/or provoking seizures.

I B
 
SSRI (citalopram/celexa) + Psychedelics

From reading over many accounts, it seems that SSRIs are more adverse to phenethylamines than they are to tryptamines.

In other words, it seems that people who have tried LSD or psilocybin have not had the same weakening of effects as with MDMA.

I have also read that citalopram (eg Celexa, Lexapro) does not affect the same liver enzymes that other SSRIs do, so may not be as adverse to certain phenethylamines.

Any input?
 
^^^The effects of LSD are weakened but not overly (for me at least). MDMA use is pointless, however I've got good effects from another phenethlamine. You'll find theres many different views on this issue
 
Stoned Again said:
So wait... if you take antidepressants, certain drugs have no effect on you?
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Many people have reported that MDMA is inneffective if they are on SSRIs (Prozac, Paxil, etc), but that there may be either some or no lessening of effects with LSD or mushrooms (seems more likely with LSD than 'shrooms).

SSRIs are contra-indicated with DXM.
 
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Stoned Again said:
So wait... if you take antidepressants, certain drugs have no effect on you?
Click to expand...

Yes... SSRIs have quite a profound effect on all sorts of mental functions, including reactions to drugs. Some are unchanged, some are altered in certain ways, and some simply cease to have any effect. That's why I always say that you should really try everything you can to solve your emotional problems without drugs before turning to them. Especially since doctors these days are prescribing them left and right like candy, you should really be careful that your doctor actually has your best interests in mind rather than his pocketbook in mind when you're prescribed them. SSRIs haven't been around long enough to have any long-term studies done on them, and they seem to permanently alter your serotonin system's workings even after you stop taking them. So just be careful, because we really don't know what the implications of that are, decades down the road.
 
SSRI (citalopram/celexa) + Psychedelics

If a person were taking 20mg of citalopram (celexa, cipramil) daily (for anxiety) would it be worthwhile to even bother with a PEA, Tryptamine, DXM, or Salvia?

From my research (erowid, google, etc), it seems more likely that PEAs (MDMA, 2c-x, etc) would be neutralized by a SSRI than a tryptamine; and LSD more likely than psilocybin (and psil~ analogs?).

I am aware that DXM is generally contra-indicated with SSRIs.

The concern is more with the possibility of serotonin syndrome than no effects at all, so if anyone can chime in in that regard, please do.

TIA
 
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Your exactly right Hellbilly, SSRI's wouldn't reduce the effect of psychadelic's because they are acting on different receptors in the brain. serotonin, which is what SSRI's are targeting, is the main ingredient for using MDMA. Tryptamines are only altering the chemistry of your brain for a short period of time.
 
Photon said:
Your exactly right Hellbilly, SSRI's wouldn't reduce the effect of psychadelic's because they are acting on different receptors in the brain. serotonin, which is what SSRI's are targeting, is the main ingredient for using MDMA. Tryptamines are only altering the chemistry of your brain for a short period of time.
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Most of what this guys saying is untrue. SSRI's do alter or reduce the effects of psychedelics, but will not cause seratonin syndrome. Seratonin is by no means an ingredient of MDMA by the way.

I wouldn't advise using DXM and definitely do not take ayahuasca or MAOI containg substance.
 
This should be a sticky. The question has been answered within the last week.

Read this thread. It will answer all your questions. Then send thanks to fairnymph for compiling the info. If anyone thinks evidence has changed w/ regards to any of the info below, bring it up. But this is the best summary I've seen for these questions.

Antidepressants and Recreational Drugs
http://www.bluelight.ru/vb/showthread.php?t=108959

READ IT!!!

READ IT!!!
 
Dondante said:
This should be a sticky. The question has been answered within the last week.

Read this thread. It will answer all your questions. Then send thanks to fairnymph for compiling the info. If anyone thinks evidence has changed w/ regards to any of the info below, bring it up. But this is the best summary I've seen for these questions.

Antidepressants and Recreational Drugs
http://www.bluelight.ru/vb/showthread.php?t=108959

READ IT!!!

READ IT!!!
Click to expand...


In that FAQ at the beginning, it lists some medications with hours after them. Is that how long the medication stays in your system?
 
Nope. In that amount of time, half of it would leave your system. Then in another amount of that time, half of what was left would leave. Then in the next interval of time, half of that amount would leave. Etc, etc. So if the half-life is, say, 4 hours, then in 4 hours, you'd ne down to 50%, in 8 hours you'd be down to 25%, in 12 hours you'd be down to 12.5%, and so on. This is how all drugs work.
 
Ohhh okay... thanks for the info. I knew it took a while... I was thinking 2-3 weeks and the med I was on would be totally out. I guess it's more like 1-2 weeks.
 
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