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The Big & Dandy Medication/Supplement Interaction Thread

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Well ive had this problem for a few years not,
http://en.wikipedia.org/wiki/Prostatitis

First year i suspected i had it, got told no your only 18 you cant have problems with your prostate,
Not "let me do a prostate exam to be safe"

But got a second opinion 3 years into problems with it and got told yes it probably is prostatitis.


I think ketamine my aggravate my prostate but im not sure yet.
Ive never done too much really, ive never done a gram in a weekend before.

There was one time, 3 months into use ketamine where i used about half a gram throughout the night, but i was also drinking orange juice ( so this might have effected it) but i thought i had what were k cramps when i peed at the end of the night on the way home, but k cramps isnt a sharp pain like a knife behind your ballbag is it, so ive never had k cramps so i dont know what they feel like
 
Doxycycline and ketamine are not contraindicated, from what I've read anyway. However, I would not recommend someone with urological problems indulge in that drug, better to wait until your issue is solved if possible (so long as you're using it in moderation there might not be any issue, but still, as Ben Franklin put it, "An ounce of prevention is worth a pound of cure."). Also, it may be worth considering getting legitimate medical/psychiatric help at some point for your mood issues (not that it's any of my g-ddamn business), it's just that self-medication can rationalize self-destructive abuse, and I'm always one to warn against that as far as dissociatives go (they can be pretty sneaky in that regard).
 
self-medication can rationalize self-destructive abuse
Click to expand...

I know! its hard because the ketahorse already got me once, i was doing it daily (because someone on here suggested i do small bumps every few days , instead of high dose at weekend)
Which i then moved to 2 days, then 1, But at around 3 weeks i thought wtf am i doing?!? but i didnt go over half a gram of it.

Im finding vaping cannabis of an evening time every night helps me though, it relaxes me and im happy, might swap raving for this tbh, be better on my happiness/ physical wellbeing
 
Extreme tolerance to psychedelics

So, I've been on Cymbalta (SNRI) for about 18-20 months, probably about half of that at 60 mg/day. While I was on Cymbalta, there was a very noticeable reduction in effects from psychedelic drugs. Specifically, I got at most a ++ from 20+ mg of 2C-P, and have IM'd 100-150 mg of 2C-C with only a brief +++ (maybe half hour or hour tops?). Now, this is to be expected as SSRI's can reduce the effects.

Recently I stopped taking the Cymbalta after weaning myself off, so that now I'm not taking any SSRI. A week or two after I stopped, I took ~100 mg 2C-C orally, with only a +/++.

My question is; has anyone else experienced this type of extreme tolerance from SSRI's and secondly, will it ever go away? Do I need to give it 6 months or so before the tolerance will drop?
 
If you check the Medication Interactions Thread you'll see that SSRIs can reduce the effects of psychedelics. Some people don't seem to experience this, or only seem to get a minor reduction in the effects - but others find it hard to trip at all without a much larger amount.

Just wait a while though, you should see it getting better with time :)
 
When I was taking zoloft for a short while I found that I couldn't really trip either. But yes, inhibition does go away. You'll probably be back to normal tolerance after 3-4 weeks off cymbalta.
 
I havent done k for 3 weeks now, im feeeling extremely suicidal then happy then suicidal then happy, Just like before i ever found K,

So is it safe to do these 2 together , because TBH i cant put up with these mood swings much longer
 
Well like I said before, they aren't contraindicated as far as I can tell (in other words, there should be no negative interaction between the two). Just keep in mind that K is bad for bladder/kidney/urological health (has your prostatitis issue been fixed?).

Oh, I'm also going to merge this with an appropriate B&D thread soon, just a heads up.
 
no thanks ketamine works good enough,

Na ive had the symptoms of prostatitis for 4 years now, it was well awkward though because i didnt understand and i actually thought id got an STD from some girl but i didnt actually so that was awkward lol, i just didnt understand the pain after and sometimes near the end of sex ???

But keep in mind ive only been doing drugs for a year today i think ,
Ive found if i do loads of ket throughout a night out , like 500mg then drink stuff like orange it causes me a flare up and it burns to pee,

I read that Chronic prostatits can be caused by too much surgical intervention , and ive had a fair bit of surgery done , and had catheters in for a while (the main cause)



***EDIT

had a few bumps, feel good , so alls good
 
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I'm going to have my first trip on mirtazapine the coming weekend. I'm on a really low dose (7,5 mg) mainly for sleep, so I hope it won't interfere with the trip too much. The substance will be a 4-subbed tryptamine, I'm just not sure which one yet. Before switching to mirtazapine I used escitalopram and it didn't effect my tripping at all. I just keep my fingers crossed mirtazapin won't reduce or even block the effects of the tryptamines.

I've taken MXE together with mirtazapin a few times already and that's totally fine, mirtazapin has no effect on the MXE experience.
 
hi all, I'm new here, I'm 57 years old, and want to try san pedro, I've never tried anything stronger than grass.
So, I did my research and correctly produced 2 lots of dried reduced liquid, neither had any effect :(.
I am on 150mg of efexor per day, and after more research, I think that may be the problem.
I took 60gm. I'm thinking of taking 120gm this time,( this quantity makes about 180 capsules ) hoping it'll get through the efexor.
I'd like some advise please, Marg.
 
Need some ASAP advice.

I am taking Wellbutrin 150mg once a day in the morning along with 2mg Xanax xr.


I have aquired 2 doses of some DMT (.05 each) and some tan colored molly...



question: Will i still trip on the DMT? and...... Will i still roll on the molly? I can't find any info on the internet and need to know ASAP.
 
Why is that? I was looking foward to going to the beach this evening with my girl and watching the sunset while on DMT


i took the Wellbutrin this morning at 7am. so it will be about 10 hours since ive taken it...

i also have access to benzo's and opiate's if that will someone balance out whatever the issue is...
 
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