The Big & Dandy Medication/Supplement Interaction Thread

[pharmakos]

alternately, you might develop serotonin syndrome

 

[Secret Agent Chick]

I thought I read somewhere that methylone (compared to MDMA) only has about 1/3 the effect on serotonin, and works more on dopamine.

My lexapro is 10mg a day and I would only be using about 100mg of methylone, once every two or three weeks.

Do you still think this would be risky?

 

[Secret Agent Chick]

This is what I found on wiki -


Methylone acts as a mixed reuptake inhibitor/releasing agent of serotonin, norepinephrine, and dopamine.[2][9] In comparison to MDMA, it has approximately 3x lower affinity for the serotonin transporter, while its affinity for the norepinephrine and dopamine transporters is similar.[2][9] Notably, methylone's affinity for the vesicular monoamine transporter 2 (VMAT2) is about 13x lower than that of MDMA.[2] The results of these differences in pharmacology relative to MDMA are that methylone is less potent in terms of dose, has more balanced catecholaminergic effects relative to serotonergic, and behaves more like a reuptake inhibitor like methylphenidate than a releaser like amphetamine; however, methylone has relatively robust releasing capabilities,[9] perhaps due to its ability to phosphorylate the monoamine transporters being similar in potency relative to MDMA



So can somebody translate what that means?

 

[Survived Abortion]

alternately, you might develop serotonin syndrome

I thought I read somewhere that methylone (compared to MDMA) only has about 1/3 the effect on serotonin, and works more on dopamine.

My lexapro is 10mg a day and I would only be using about 100mg of methylone, once every two or three weeks.

Do you still think this would be risky?

No, serotonin syndrome won't be a problem either. Again, it's only an issue with MAOIs.

Over the years I've taken MDMA more times than I can remember whilst taking various doses of venlafaxine. I've taken immense amounts of MDMA in a single night, many times. I have also used countless amounts of 5-HT psychedelics whilst using venlafaxine. I have never once run into any problems remotely resembling serotonin syndrome.

This is what I found on wiki -


Methylone acts as a mixed reuptake inhibitor/releasing agent of serotonin, norepinephrine, and dopamine.[2][9] In comparison to MDMA, it has approximately 3x lower affinity for the serotonin transporter, while its affinity for the norepinephrine and dopamine transporters is similar.[2][9] Notably, methylone's affinity for the vesicular monoamine transporter 2 (VMAT2) is about 13x lower than that of MDMA.[2] The results of these differences in pharmacology relative to MDMA are that methylone is less potent in terms of dose, has more balanced catecholaminergic effects relative to serotonergic, and behaves more like a reuptake inhibitor like methylphenidate than a releaser like amphetamine; however, methylone has relatively robust releasing capabilities,[9] perhaps due to its ability to phosphorylate the monoamine transporters being similar in potency relative to MDMA



So can somebody translate what that means?

Secret Agent Chick, the quote you mentioned is saying that methylone acts more like methylphenidate (Ritalin) than an amphetamine as it pertains to it's action on dopamine/norepinephrine. It says that it's effects on serotonin are more 'in balance' than MDMA as it pertains to it's action between the DA/NA system and the serotonin system. Cocaine is also a DA reuptake inhibitor; it seems that DA reuptake inhibitors are generally more fiendy than amphetamine-style DA releasing agents.

That would translate to methylone having a heavier stimulant to loviness ratio (more stimulant than mashy) than MDMA, which is more lovey than stimulating.

 

[Secret Agent Chick]

Thanks heaps S.A. .... that helps

 

[purpleAPY]

zoloft and lsd

I've been taking zoloft for like 6 months now (really sporadically though because im really bad at remembering to take it). i've also only been taking 50mg. my friends are getting acid for this weekend and i've tripped on acid twice before (once with 1 hit and once with 3). im not sure if i should get 2 or 3 hits... ive read that zoloft can diminish the effects of acid but im just not sure whether its worth wasting money on just one hit or two hits if its not going to be enough, but i also dont want to buy 3 and end up tripping too hard or something. cause everyone else is just taking 1 hit so i dont want to be tripping way harder than everyone else

 

[purpleAPY]

anyone?

 

[allium]

If you have no idea of how Zoloft will interact with LSD in your body, better don't take LSD.
No one can answer with this question, because
a) blotters have verying potency, I'd suggest checking FAQ(that green blinking link)
b) LSD can affect different people in different ways, so different people need different dose
c) LSD and Zoloft can interact differently in different people. There are some people who won't notice any interaction, and there are some who won't trip on 3(4,5,6) hits
But yes, generally SSRIs(including Zoloft) diminish effects of psychedelics.

Did you take any psychedelics while being on this medication?

 

[purpleAPY]

i havent so far. im thinking that it wont affect it too much especially since im only taking 50mg and taking it pretty sporadically, like i'll skip days at a time (not intentionally but i'll just forget or something). i also know i'll be with people i trust completely if i were to have a bad trip. im getting 2 hits but apparently they're liquid hits on sweet tarts and ive heard that liquid acid can be a lot more potent than blotter

 

[Corporatedroneguy]

Abilify and Mescaline: Please respond

Greetings,

For the past two months I have been taking abilify in 5 mg tablets daily to help with a case of mild depression. I feel mentally stable, so while I understand concerns regarding whether I should experiment with psychedelics in the first place, I will kindly ask that you please do not bring them up. I've given this much thought and I know I have a good mental set for a trip. So here's my predicament..

As I mentioned earlier, I'm taking 5 mg of abilify daily. It has a 75 hour half-life, so that means as of two days ago-when I stopped taking my abilify-I had 31.25 mg in my system. According to my calculations, by next saturday I will have 5.5 mg in my system, and by the saturday after next I will have 1.61 mg in my system. The psychedelic I have chosen to use for my trip is mescaline, contained in San Pedro cactus.

Do you guys think that 5.5 mg of abilify in my bloodstream is enough to agonize my 5h2a receptors to a point where the mescaline will not have a significant effect on me? Or is it best if I wait until the next next weekend. I would appreciate personal experience as well as scientific insight. Thank you!

P.S. sorry for any ignorance on my part. Please correct any mistakes I have made.

 

[abrad84]

If I were you I would resume taking your medication and avoid psychedelics unsless used in a theureputic manner under the supervision of a medical professional.

 

[HigherAwareness]

Does anyone have experience with the SSRI Lexapro and psychedelics? Will the effects still be lessened with a very small daily dose (10 mgs) ?

This is a great thread.....To answer your question. Lexapro will absolutely detroy your roll. MDMA will be futile if your on lexapro. It doesent seem to effect other psychedelics though

 

[shewei]

Hi all, first post for me, always been more of a lurker than a poster heh. I tried to search this thread for it and the bluelight forums in general but i couldnt find a definitive answer.
Ive been on Celexa (SSRI) for a couple of months now and i was wondering if it would be allright to take a small dose (ca. 150mg) of 4-fa at a party im going to next week. Will it have any effect? And should i be worried about serotine syndrome? Thanks!

 

[tokki g]

I read through this thread and from what I can tell, abilify decreases the effects of mushrooms - but I take it every morning and have tripped just as hard as anyone else. Then again, I usually have taken mushrooms towards the afternoon or night, so it's not exactly at the same time as the abilify.

I also take lamictal, but I really can't stop that as I would have to taper up when I started again. So far I haven't noticed any interaction between abilify, lamictal, and psychedelics, but I would really like to have a strong trip on mushrooms so... should I stop the abilify for a couple days?

Holy fuck, maybe this explains my "tolerance" to tryptamines (experience with shrooms and 4-AcO-DMT)! I was gonna post in this thread saying that abilify doesn't really affect your trips since I'm on abilify and have tripped just fine, but always at a much higher dose than most people. I usually don't take my wellbutrin and abilify the day I trip, but I don't think that helps much as abilify has a half life of 75hrs. I don't think dosing 12hrs after you take the abilify will significantly decrease the effects of abilify on your trip due to it's long half life.

Anyways, I usually take ~50mg of 4-AcO-DMT or 1/4oz shrooms and have a ++/+++ trip whereas other people take like 20mg or an eighth of shrooms to get to the same level; I thought I just had a natural tolerance. That's really too bad, abilify has helped me so much with my personal life and I really don't want to stop taking it. Guess I'll just have to deal with the higher dosages.

On a related note, abilify doesn't seem to have TOO much of an effect on PEAs. I usually take 25-30mg 2c-e and trip pretty hard. I would taper off the abilify and try to trip off of tryptamines and post a report noting differences, but I'm very reluctant to change up my meds for the sake of recreation.

I've tripped off of various PEAs mostly of the 2c-* family (mostly 2c-e), tryptamines (4-AcO-DMT and shrooms), and LSD and was on the following daily medication regimen during my experiences with the above substances:
300mg wellbutrin
5mg abilify
70-140mg vyvanse
0-10mg adderall (generic)

I also keep clonazepam around for anxiety and in case trips get crazy, but I try to limit my use due to the addictive nature of benzos.


Hope this helps someone.

 

[shewei]

Hi all, first post for me, always been more of a lurker than a poster heh. I tried to search this thread for it and the bluelight forums in general but i couldnt find a definitive answer.
Ive been on Celexa (SSRI) for a couple of months now and i was wondering if it would be allright to take a small dose (ca. 150mg) of 4-fa at a party im going to next week. Will it have any effect? And should i be worried about serotine syndrome? Thanks!

modest bump if thats cool with the mods

 

[arctica]

Would a dose of Klonopin or another anticonvulsant be protective against the risk of taking Wellbutrin along with another drug known to lower the seizure threshold?

 

[PepperSocks]

As generally all benzodiazepines increase the seizure threshold the answer is obviously yes. I take it the "another" drug you're talking about taking is a psychedelic and/or stimulant.

It gets kinda tricky as I assume you're on wellbutrin in the first place for an imbalance of sorts. You're best off waiting for the imbalance to get to a manageable point, stop taking wellbutrin under doctor's guidance and then having a healthy unimpeded experience.

Taking benzodiazepines will increase the seizure threshold but it also numbs the psychedelic experience. I haven't read much on wellbutrin/psychedelic interactions, take my words as an idea; they might be compatible after all, but it's best to read up on the matter thoroughly.

 

[clubberdude]

I've got an interesting experience to add here to SSRI's and serotonergic drug interactions. I've just come off Sertraline (around 3 and a half weeks ago, at a low dose of 50mg every 2-3 days typically). I typically stop the SSRI for around 3-4 days before taking a psychedelic/MDMA which gives me close to the full range of effects with maybe a slight muting. Now I have tried aMT before whilst on the SSRI (though using the same protocol with the SSRI - aMT gap of 3-4 days), taking approximately 70mg and being somewhat underwhelmed by aMT. It was nice, but felt like doing half a tab of acid with a small amount of speed. Anyway, took a tiny dose of aMT (approximately 20-25mg) last Saturday afternoon (this was just to lighten my mood, had no intention of using it for a strong effect) and wow, the aMT was a completely different beast - felt almost identical to 150mg of MDMA (my previous use of aMT yielded little euphoria, maybe similar-ish to low dose speed) and was completely blown away by the effects of the aMT. Previous to this, I was thinking of doing 100mg of aMT as I thought I had a massive intrinsic tolerance to it, but bloody glad I hadn't as it would have overwhelmed me, no doubt! Its made me wonder whether Sertraline blocks the exact same receptor subgroups as the aMT; the reduction i get in MDMA is a fraction as strong as it seemed to be for aMT. I also took aMT the next day (Sunday, around 30mg) and still experienced strong euphoria, so believe coming off the SSRI was the main factor here. There seems to be a strong afterglow with the aMT as well, my mood is noticeably better than it was before the weekend.

On the point of psychedelics and SSRI's, taking the Sertraline the same day as MDMA, blunts around 70% of the MDMA's euphoric effect. This reduces to around 0% (though I do pre-load with Piracetam before MDMA use) at about 4 days. However, use of the SSRI seems to make the euphoric phase of the MDMA far shorter than I remember it doing before using the SSRI (maybe 3-4 hours as opposed to 5-7 hours if dosing protocol is timed right). Using LSD the same day as Sertraline leads to a 90+% reduction in effect, falling to around 50% I'd say after 4 days (though this is an estimate as I'm not heavily experienced in LSD use), but again, a substantitive reduction in duration in effect is experienced (4-6 hours rather than 8-10 hours). With MDAI, I'm not sure about effects as I haven't tried MDAI after quitting the SSRI. 2C-I, 2C-P and DOC, not seen any obvious effects (maybe similar to MDMA), but again, have only done these a few times.

Those are my experiences. I have a feeling that Sertraline seems to affect Tryptamines way more than Phenethylamines in my experience (I guess that may be because Phenethylamines have a more dopaminergic component though could be wrong).

 

[Darksidesam]

doxycycline + ketamine. Is it safe to mix antibiotics and Ketamine ?

Hey , ive just been put on doxycycline, in hope it will treat my prostatitis. (Which ive had for around 3 - 4 years, Drug use started just under a year ago ) Im on this for 28 days.

I do like to do ketamine weekly, as it stops my mood swings but obviously i want to know if its safe to mix both?

Obv i wouldnt mix mdma with it,
Anywho if not, new years looks pretty boring atm lol

 

[cannibalsnail]

I'm on Lymecycline (another tetracycline antibiotic) and AFAIK it doesn't cross the blood brain barrier so you should be OK. I've taken numerous psychedelics and Nitrous oxide (another dissasociative) and been fine.

That said someone else may know more than me.