Every time I've plugged 2C's on an empty colon, it's burned like the fire of a thousand suns. Also, in my experience, nausea is not significantly reduced as compared to an equivalent oral dose, but I don't get that nauseated when I eat psychedelic phenethylamines, except at very high doses. Even though it's more economical to plug 2C's, I still prefer eating them.
On the other hand, I had great success plugging synthetic mescaline. The burning wasn't too bad, and a dose that would have been threshold orally (250-300 mg) instead induced a moderately intense trip.
On the other hand, I must second everybody who recommended plugging 4-HO- or 4-AcO- substituted tryptamines. As Xorkoth said, this halves the required dose, and the transition from sober to tripping is quick and smooth.
On the other hand, I had great success plugging synthetic mescaline. The burning wasn't too bad, and a dose that would have been threshold orally (250-300 mg) instead induced a moderately intense trip.
On the other hand, I must second everybody who recommended plugging 4-HO- or 4-AcO- substituted tryptamines. As Xorkoth said, this halves the required dose, and the transition from sober to tripping is quick and smooth.