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☛ Official ☚ The Big & Dandy DOC Thread - Third opinion

Wow, that's a pretty raw story. A lesson to us all when handling these mad potent chems. I hope he recovers safely!!
 
Asante said:
At the Shroomery we're having a member return from the hospital. He had gotten into a benzo blackout and had a sizable tolerance for psychedelics. He ended up taking approximately 100mg DOC over 2 days (among other psychedelics in far less extreme doses) This resulted in him getting severe vasoconstriction. Circulation got cut off to his feet resulting in huge blisters and blackening. They had him on 15 IV drips at a time and ran a total of 55 drugs through him, nothing worked. They made incisions in his calves to drain the pooling blood, they scheduled a surgery to amputate both his legs from the knees down... He made a miraculous recovery and now might lose several toes, but not his legs.

We're showering him with the best vibes we have, wow :(
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Hi Asante!!

Funny to see you on here, I've seen you post here before too.

P.S, Zombi3 said the one who convinced him to go to the ER was me. I'm such a life-saver.

First I helped save Lostfreddy in the 2C-P overdose, then I helped save St1llnox in the eyedrops overdose, then I helped save Zombi3 in the psychedelics overdose.

P.S,

I love you

P.S,

Hi
 
Help?!?! said:
What stops LSD would stop DOM as well.

Heading for some DOC on Thursday. Pretty excited as I haven't been tripping to much lately.
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Not necessarily.

What matters here is the ability of chlorpromazine to "knock away" the molecule of LSD or DOM from the receptor.

Given what we know about both LSD and DOM (namely that LSD is a weak partial agonist of 5ht2a, while DOM has high affinity and intrinsic activity) it wouldn't be particularly surprising to learn that they don't behave identically in the presence of an antagonist.

However, a quick search seems to indicate that chlorpromazine works perfectly fine for counteracting the effects of DOM at the 5ht2a receptor.
http://psycnet.apa.org/psycinfo/1989-32274-001

Of course you've got to keep in mind that DOM, like other psychedelic amphetamines, isn't truly selective for 5ht2a--and off-target effects would become even more pronounced in instances of overdose. Furthermore, chlorpromazine itself is an incredibly powerful psychoactive drug with affinity for quite a few receptors and unpleasant effects. Administering enough chlorpromazine to negate the effect of a DOM overdose on 5ht2a receptors might not exactly render the patient "sane."

All this being said, I think the old "Thorazine and STP" scare is a bit of a modern myth, maybe based on the interaction between chlorpromazine and PCP.
Consider this study:
http://www.ncbi.nlm.nih.gov/pubmed/4860952
Which specifically mentions that chlorpromazine "does not accentuate the effects" of DOM.

Still, an atypical would do a better job--those hit 5ht2a more significantly while reducing some of the off-target effects.
 
One time I accidently took WAY too much DOC (on blotters I had made myself, but sat with a friend for a couple years) and after a couple hours of "Ok, handled 2 hours i can't do it for another 20" and ate some Seroquel. Well, Seroquel sucks at stopping a DOC trip, although I only took 50mg (took that much because I knew that 25mg would normally knock me out to sleep very hard). Not only did Seroquel not really weaken the trip at all, but made it worse because even weirder shit started happening (prob ingested like 6mg DOC which is too much for me)

What I have found works the best, every time, is Remeron (mirtazapine). Only half of a 30mg pill was enough to 100% totally stop a DOC trip, a +++ 2c-t-7 trip... and another time I had to stop a 2c-t-4 trip because I was notified of a surprise family get together right when I started tripping hard :). 45 minutes after eating the mirtaz the trip starts to slow down and then in another 15 mins its completely gone.

Mirtazapine is great to have around just for that purpose. I used it once when I took DOC late in the day because I wanted to trip for like 6 hours... or til i got tired of it or just wanted to go to bed. Took half a Remeron an hour later trip gone and went to bed. I don't know why things sometimes don't seem to make sense - like people will argue too much about how Seroquel should technically work better or thorazine or whatever etc but Mirtazapine to me is the one you should be stashing away (well, a benzo stash is a good idea too). The shit works I have confirmed it at least 5 times with myself (an accidental oops I should have not IMed that much 2c-t-7, oops that DOC blotter must have gotten wet or i forgot my own dosing, 4-AcO-MET a strange freak out / panic, and DOC again cause I wanted a short trip)
 
Asante said:
At the Shroomery we're having a member return from the hospital. He had gotten into a benzo blackout and had a sizable tolerance for psychedelics. He ended up taking approximately 100mg DOC over 2 days (among other psychedelics in far less extreme doses) This resulted in him getting severe vasoconstriction. Circulation got cut off to his feet resulting in huge blisters and blackening. They had him on 15 IV drips at a time and ran a total of 55 drugs through him, nothing worked. They made incisions in his calves to drain the pooling blood, they scheduled a surgery to amputate both his legs from the knees down... He made a miraculous recovery and now might lose several toes, but not his legs.

We're showering him with the best vibes we have, wow :(
Click to expand...


The pictures from that are horrifying I dont want to drop gore like that on people who may be tripping so I wont post those here but check it out.
http://www.shroomery.org/forums/showflat.php/Number/21752039/fpart/1
 
LSD Cruiser said:
Best of luck to him, but wow, what the fuck was he thinking intentionally ingesting that much?
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You have obviously never had a benzos blackout and you don't want to ever. People do dumb, dangerous things usually when out. So it wasn't really intentional.

I loved DOC, I used between 2-3.5mg doses and sometimes combo'd with 2C-I and/or LSD which were perfect additions.
 
I can attest to dumb Desicion making while blacked out on benzos

3 years ago I thought it was a good idea to order some phenazepam.....I have about a week long blank in memory from that stuff....did stuff that I would never ever do sober....hell I did stuff that I don't even do when drunk or high
 
Yesterday I did 10 mg of DOC. Today I intramuscularly injected a nice bit of 2C-B (using a long needle). I don't feel a thing. Is that because of the 10 mg of DOC I did yesterday?
 
DOC is a fascinating compound. Y'all might disagree but in my mind it also has a dissociative quality as well absent from some other psyches which allows experiences that would floor a person to be navigated more easily. That is why this is a great psychedelic for spiritual work or a profound day. Something needs to be said about the muscular tension I experience with this substance. It is unusually high for me. I find myself undergoing conscious seizures at times. Not random seizures, but rhythmic movement in my limbs. It is quite pleasurable and my way of releasing excess tension but could be a cause for concern for someone inexperienced. Lower doses will produce less tension so dose accordingly and walk briskly during come-up to help dissipate the tension. Another technique that words very well for me is to sit in a bath of warm water during come-up but is not for everyone. I've pushed the dose high with this compound and had some terrifyingly profound experiences. I wouldn't recommend high doses of this compound except for seasoned psychonauts with a focus towards personal exploration, and then, only after working successfully with the lower doses. Anyways, sorry if I'm repeating things that have been said, but it's a remarkable psychedelic that will treat you well if you treat it with respect.
 
DOC doesn't have a dissociative feel to me. maybe just because i have a huge dissociative tolerance, but DOC almost feels like the opposite of dissociation to me...
 
I also find it to be pretty much the opposite of dissociating, though at high doses I have been pretty in my head when choosing to listen to music rather than be active. I find that DOC focuses me to a very intense degree... I will get very into what I'm doing. I feel very present and together on DOC, it enhances my sense of self in a very non ego-driven sort of way if that makes sense. Similar to how mescaline is, I feel in touch with my animal self and my mental nature.
 
DOC is exactly the opposite of dissociative, psychedelics in general are in many ways the opposite of dissociatives (even tho both produce a lot of similar effects due to being hallucinogens), as they increase associations/connections, and DOC does this in the most powerful way of any psychedelic I've done. As well I agree with Xorkoth about DOC enhancing the sense of self, doing so while still softening the ego as well. DOC makes me feel more in tune with my true self, truly a powerful & unique chemical! It definitely does make me "more in my head" but that's what psychedelics do, I always go deep into my thoughts, but also feel more connected to my surroundings simultaneously, my favorite state of consciousness.
 
SteamboatBillJr said:
DOC caused seizures, does this happen frequently? You mentioned this as if this happened multiple times.
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"Conscious seizures"

Consider the head twitch response in rats. It's most likely that he is referring to the tendency for 5ht2a agonists to cause muscle tremor.

This being said, I've never noticed any tremor from DOC. This seems to occur only with tryptamines for me.
 
my3rdeye said:
The pictures from that are horrifying I dont want to drop gore like that on people who may be tripping so I wont post those here but check it out.
http://www.shroomery.org/forums/showflat.php/Number/21752039/fpart/1
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I disagree. We shouldn't censor the effects of this drug. This drug has risks and we should show the risks honestly in this thread, the same as the Shroomery did. If we censor these images and don't show them in this thread we put peoples safety at risk. If you use DOC you should have familiarity with the effects of overdose. I don't condone this censorship.

These are the images of DOC overdose:


pSsPWwD.jpg


tfw0aI4.jpg


9Wxs92g.jpg
 
The above pictures are from a 100mg overdose, it should be mentioned. Of course one should always treat DOX chemicals cautiously and with great respect, and with intense observance of accurate dosing via liquid measurement, and careful handling in powder/crystal form. And if your vendor also supplies a DOX like DOC, and you get something else, do a reagent test and allergy test before diving in to something with a much higher dose... that is one way death and harm comes from these substances, misidentification.

Assuming you take the proper precautions, DOC seems pretty safe at normal recreational doses. But it definitely requires more care than most psychedelics because of its potency. If you took 30 times the standard dosage range of something like 2C-B or 2C-E, I'd expect some serious repercussions as well. Perhaps even with the tryptamines.
 
This is exactly the kind of censorship I'd like to see on TV. None.

I think people would be a little more wary about advocating war if they knew what war is really like. It's not all hero's & winning. It's about losing, & losing your best friends in the most horrific way too.

If the TV news displayed the harms that alcohol causes with the same degree of censorship on display here, alcohol would be banned within six months.

Drugs are dangerous, & no amount of new legislation will change that, but old legislation could be changed to make drugs users safer & I fail to see why that is not done. A legal market for drugs & proper education about their idiosyncrasies would reduce the risks of harms such as those shown above, which unfortunately are still dwarfed immensely by the harms of alcohol.
 
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