i take lexapro 10 mg and have taken methylone several times. read the wikipedia article-mostly dopamine
The Big & Dandy bk-MDMA (Methylone) Thread
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i take lexapro 10 mg and have taken methylone several times. read the wikipedia article-mostly dopamine
maybe your taking ssri's inhibits the serotonergic effect. 200-250mg of methylone for me feels almost identical to mdma.
i've once made a graph of reuptake inhibition data where i plotted 1 / IC50 for serotonin, dopamin and noradrenaline as pie charts. here is a small extract:
the upper row shows the ratios for serotonin, dopamine and noradrenaline and the lower row are just serotonin and dopamine.
of course reality is much more complicated than these graphs; and neurotransmitter release is unaccounted for, because i couldn't find data for all substances (e.g. methylone).
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on mephedrone: a major metabolite of mephedrone is a proven cardiotoxin, there are reports of vasoconstriction (or maybe strange immune reactions??; knees turning blue) and it has a methyl group on the para position of the ring, just like p-methyl-amphetamine (sounds toxic from descriptions and is most probably a potent neurotoxin). the methyl group is similar in size to a chlorine atom and p-chloro-amp is a proven neurotoxin. so i wouldn't touch mephedrone with f&b's proverbial shitty stick
on the other rc's: if you're going to take a stimulant (semi-)regularly why use new substances with (next to) no research on them and their long term effects? with amphetamine and methylphenidate we have compounds that have been in use for many decades with a lot of research behind them and they even get used in a medical context. i'd really settle for one of these than taking the risk of overdoing some obscure chemical with completely unknown long term effects. that aside mdpv to me seems to be the most benign of the bunch, but i haven't done much research on buphedrone and the like...
Fair enough, I apologise for making assumptions - do you by any chance have a source for this speculative cardiovascular/liver/kidney damage? I was unaware of this, would be interesting to read more on the subject.
ebola?
Bluelight Crew
It 'seems' less neurotoxic according to research by Dr. Nichols et al.
This is problematic, as all of the above substances act primarily as releasers, not reuptake inhibitors. However, IIRC, the gist of the proportions for follows the data you present pretty closely.
ebola
Methylone - My first experience
Well a couple of weeks back a mate and I went camping in Snowdonia. We took with us, some cannabis, some methylone powder and capsules obtained from a website in the UK and some PCP.
I've been taking MDMA for over 15 years, but not for the last few years due to the terrible quality available. I remember the good days of MDMA but is has lost the 'magic' for me.
We dropped the methylone capsules after a few pints of beer, the capsules contained ~200mg of Methylone with 200mg of pure glucose and maize starch. After 20 minutes we both felt the first alerts, then the come up was very strong, extremely similar to MDMA. Within 30 minutes we were both rolling. I would say that surroundings are extremely important, and the beautiful scenery, the camp fire and the presence of a great mate made all the difference.
The euphoria and empathogenic effects were actually stronger than MDMA, but the whole experience seemed much more controllable. If you wanted to chill a bit it was easy, but if you wanted to push the rush that was easy too....eye jitters, tingling, everything. It felt so clean. Remember your first pill? It was just like that at first....the magic is back!!
We were both amazed by the quality of the drug and it's legal status. The words "I can't believe this is legal" were used several times.
One hour after the initial dose we dissolved a further 100mg each in water, and a second rush was felt. Not as strong as the first, but definitely worth it. It wasn't at all more-ish but perhaps that's because I knew from research on here that there was no point in taking any more following the first bump.
I would highly recommend this as an alternative to street MDMA. It doesn't last as long and is much more controllable.
Smoking cannabis on this was excellent, especially during the come down.
On the second night we tried a few dabs of PCP following the same methylone dosage as above (bought from the street so of questionable purity). The PCP was horrible, it made the whole experience feel dirty and speedy.
The experience taught me that I'll never buy illegals again, unless I know the guy that synthesised the stuff! bk-MDMA is excellent, I'm yet to try it in a club etc....but we'll see. I'll avoid PCP like the plague, dirty horrible stuff.
Cheers
Robbie
Well a couple of weeks back a mate and I went camping in Snowdonia. We took with us, some cannabis, some methylone powder and capsules obtained from a website in the UK and some PCP.
I've been taking MDMA for over 15 years, but not for the last few years due to the terrible quality available. I remember the good days of MDMA but is has lost the 'magic' for me.
We dropped the methylone capsules after a few pints of beer, the capsules contained ~200mg of Methylone with 200mg of pure glucose and maize starch. After 20 minutes we both felt the first alerts, then the come up was very strong, extremely similar to MDMA. Within 30 minutes we were both rolling. I would say that surroundings are extremely important, and the beautiful scenery, the camp fire and the presence of a great mate made all the difference.
The euphoria and empathogenic effects were actually stronger than MDMA, but the whole experience seemed much more controllable. If you wanted to chill a bit it was easy, but if you wanted to push the rush that was easy too....eye jitters, tingling, everything. It felt so clean. Remember your first pill? It was just like that at first....the magic is back!!
We were both amazed by the quality of the drug and it's legal status. The words "I can't believe this is legal" were used several times.
One hour after the initial dose we dissolved a further 100mg each in water, and a second rush was felt. Not as strong as the first, but definitely worth it. It wasn't at all more-ish but perhaps that's because I knew from research on here that there was no point in taking any more following the first bump.
I would highly recommend this as an alternative to street MDMA. It doesn't last as long and is much more controllable.
Smoking cannabis on this was excellent, especially during the come down.
On the second night we tried a few dabs of PCP following the same methylone dosage as above (bought from the street so of questionable purity). The PCP was horrible, it made the whole experience feel dirty and speedy.
The experience taught me that I'll never buy illegals again, unless I know the guy that synthesised the stuff! bk-MDMA is excellent, I'm yet to try it in a club etc....but we'll see. I'll avoid PCP like the plague, dirty horrible stuff.
Cheers
Robbie
johannes kreisler
Bluelighter
sorry, but sounds pretty much like BS. you need to TALK. visit a therapist (NOT a psychiatrist).
do you have experience with "serious" psychedelics?
and btw: do not tune down every 'habit' all at once. start with the downers. benzos are fucking your soul. then the uppers. then the kratom.
did you ever try kava? helped with the benzo-temptation...
exercise - experience nature!
small steps my friend! (and please don't let yourself get fucked by psychiatry or esoteric pseudo-medicine...)
DwayneHoover
Bluelighter
trans-cranial magnetic stimulation is an absolutely real thing, used mostly in research to date strong magnetic fields absolutely DO induce currents in the electrically conductive nerve tissue in the brain... duh... why would it not? Look it up. I also think I did see articles about research showing it could be useful to treat certan disorders but wasnt aware it had progresses far enough for them to be sure exactly how to use it for what, so I would carefully check their credentials for using it and ask for info/documentation ab out the prpcedures a protcalls they would be using. I would think it could screw something up or cause siezures if not done right.
ebola?
Bluelight Crew
Off-topic, to Txern:
Hi. I used to work in the psych lab that used TCMS as one of its techniques. TCMS actually disrupts and 'knocks' out coordinated neural signaling in the area to which it is applied (these are rather gross, large anatomical areas). I'm not sure if it could be used to induce a seizure if the 'gain' were turned up high enough and it were applied to the wrong area, but the norm is to reduce or eliminate activity. Also, given that a magnetic field has to penetrate soft tissue and skull before affecting neurons in grey matter, TCMS is quite an imprecise instrument, and it cannot easily affect areas more deeply embedded than the cortical surface, eg limbic and hippocampal circuits key in mood.
I wouldn't put too much stock in a single study showing high efficacy; one could dig up these sorts of studies for SSRIs, for example. At its best, i predict TCMS to exert efficacy similar to electro-convulsive therapy, but with fewer side-effects. Why not try a multi-pronged attack rooted in conventional therapies, involving cognitive-behavioral sessions and routine techniques, relative abstinence from recreational drugs (stimulants and empathogens in particular), regular aerobic exercise, a healthy diet, meditation, and adjunct medication (if the latter's your fancy...I don't put much stock in SSRIs and their ilk)?
...
re: m1's more-ishness:
I would say that m1 'feels' more-ish / would be moreish in that there is strong post-peak redose compulsion, but the redoses don't work. IME, it takes 1 or 2 redoses to give up and call it a night.
ebola
Hi. I used to work in the psych lab that used TCMS as one of its techniques. TCMS actually disrupts and 'knocks' out coordinated neural signaling in the area to which it is applied (these are rather gross, large anatomical areas). I'm not sure if it could be used to induce a seizure if the 'gain' were turned up high enough and it were applied to the wrong area, but the norm is to reduce or eliminate activity. Also, given that a magnetic field has to penetrate soft tissue and skull before affecting neurons in grey matter, TCMS is quite an imprecise instrument, and it cannot easily affect areas more deeply embedded than the cortical surface, eg limbic and hippocampal circuits key in mood.
I wouldn't put too much stock in a single study showing high efficacy; one could dig up these sorts of studies for SSRIs, for example. At its best, i predict TCMS to exert efficacy similar to electro-convulsive therapy, but with fewer side-effects. Why not try a multi-pronged attack rooted in conventional therapies, involving cognitive-behavioral sessions and routine techniques, relative abstinence from recreational drugs (stimulants and empathogens in particular), regular aerobic exercise, a healthy diet, meditation, and adjunct medication (if the latter's your fancy...I don't put much stock in SSRIs and their ilk)?
...
re: m1's more-ishness:
I would say that m1 'feels' more-ish / would be moreish in that there is strong post-peak redose compulsion, but the redoses don't work. IME, it takes 1 or 2 redoses to give up and call it a night.
ebola
johannes kreisler
Bluelighter
I do know TMS from personal experience (major depression); besides I'm going for a career as a therapist (been studying psychology for some years now).
and from my point of view Txtern does not need (obscure) psychiatric intervention but a psychological/behavioral/spiritual approach. d'accord with ebola.
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btw: english is not my 1st language. always feel that I can't express myself properly and sound "incompetent"...nevermind...
and from my point of view Txtern does not need (obscure) psychiatric intervention but a psychological/behavioral/spiritual approach. d'accord with ebola.
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btw: english is not my 1st language. always feel that I can't express myself properly and sound "incompetent"...nevermind...
ebola?
Bluelight Crew
You sound competent, and it appears that we agree.
organicshroom
Bluelighter
In my opinion the toxicity of methylone ain't much of a concern at all considering that recreational doses(<150mg) of M1's stronger big brother MDMA is agruably non neurotoxic.
cheap methylone
can anybody tell me what the symptoms are of cheap dirty methylone. works very briefly with hardly near the euphoria , and then becomes very speedy and then speediness comes back again later. my first 2 batches were not even close to this shit. can anyone tell me about their experiences and symptoms with dirty cheap methlone? thanks
can anybody tell me what the symptoms are of cheap dirty methylone. works very briefly with hardly near the euphoria , and then becomes very speedy and then speediness comes back again later. my first 2 batches were not even close to this shit. can anyone tell me about their experiences and symptoms with dirty cheap methlone? thanks
ebola?
Bluelight Crew
This is conventional m1 after your brain adapted to repeated experiences with the drug.
DwayneHoover
Bluelighter
No, I have done methylone hundreds of tmes. Those symptoms are due to lousy methylone from a profiteering supplier who is giving you a small fraction of real methylone cut with stim(s) of some type.
Really does not work to redose in the same night, but Ive done is sev eral days in a row to continued great effect. 175mg at first is generally minimum for that euphoric pulse at 45-60 mins... going up a little subsequent days to max of 195mg... above that is pointless. After a few days in a row though give it a rest, lot of rest, vitamin supplements, ANTIOXIDANTS especially, and later it will continue working great. Your source is trying to stretch his profits to your detriment.
Find a source with true pure product.
naginnudej
Bluelighter
...sounds like you've killed it for yourself more than anything.
DwayneHoover
Bluelighter
Huh & WTF? Where did that nasty confrontational remark come from? Still works great for me cap'n. Possibly due to taking care to use plenty of supplemental antioxidants, brain & cardio protectants as well as cycles of nootropics. Hasn't lost one bit of magic for me and I've never felt any toxic feelings or even a "comedown" whatever that is (yes, it eventually and slowly stops working and later the stimulant effect wears off and I have a beer and some food and more vitamins and a nice long snooze. What's not to like? I didnt mean hundreds of times in like the last few months or anything. Like over 15 years. And OK "hundreds" was probably an exaggeration... but its alot! Oh and I always get direct from a high quality businesslike no-nonsense research supply provider... never from some random individual joker email vendor dude or something... they'll often cut it (and everything else) with who the hell knows what, fuckers.
naginnudej
Bluelighter
Lol sorry about that. Seriously misread your post--not sure how that happened. Wasn't meant to be confrontational anyway 
Listening
Bluelighter
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A little update: we made another attempt yesterday. This time, trying to ensure that we got full effects, we each dosed 180mg of methylone and 100mg of MDAI; a popular combo for many people these days it seems. Surprisingly though (to me at least) both of us just felt "more of the same" in that we felt that the experience was almost identical to the previous one, albeit MORE. We spoke non-stop, intensely, for about 7 hours with a deep loving connection, and at a mile a minute.
Actually it was awesome. However, I'm still pretty sure that neither of us really experienced more than a glimpse at the euphoria that my mind's eye associates with MDMA and the like (keep in mind I've never tried MDMA so I'm aware of the possibility that my expectations are all wrong, but at least I don't feel that's the case). Maybe this is all just set and setting? We had good music playing but maybe if we blasted it and forced ourselves to shut the fuck up for two seconds we would have had a very different experience?
Or should we just pump the dosage up yet again?
how experienced are you with both substances alone? a lot of people find methylone to only become truly euphoric at 190-200mg. (could be a bit less when combining with mdai... 8))
how did the effects evolve over the duration? 7 hours seems like a long time. do you think the mdai extends the duration of the (methylone-)high?
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