The classic (extreme/very shocking) counter-example is thalidomide. Two "versions" of this substance exist. They are made up of exactly the same numbers and types of atoms and all atoms are connected in a very similar way, so that one version is the same as the mirror image of the other version (just like a right hand and a left hand). This is called chirality. They
are almost identical, that is,
much closer than mescaline and allylescaline. One version of thalidomide is a teratogen and causes severe adverse effects when ingested during pregnancy. The other is a sedative and antiemetic.
I'm certainly not implying anything like these side effects for allylescaline! My point is, that structural similarity is an
indicator for similar biological effects but it is not always strictly complied with. Unforeseen effects could possibly occur!
Higher potency can certainly lead to narrower 'safe dosage window'. This is just not known at the moment for allylescaline. It seems unreasonable to just rely on this assumption, it is your health at risk.
Don't want to sound rude or offend anybody. Just wanted to throw in a bit of harm reduction resp. risk awareness.
I'm all for unlocking this interesting substance's full potential, as you say DylanG204, but this is best done in small steps beginning from small doses and not relying on assumptions that rest on unknown variables.
Stay safe
The story of thalidomide is always tragic but fascinating to tell, so nice one on that. But I think you are confusing people here talking about isomers. Because that is what thalidomide's issue was about and somehow it was not seen in trials and became a disaster. One of those things that takes a long-term observation or study to become apparent.
Allylescaline is not so new, but not widely used either. It may cause birth defects at doses even lower at psychedelic doses, and
it might be both existing isomers that do it. The topic is irrelevant.
As a reminder to non-chemists: if nothing is defined about a compound, like S and R ketamine or dextro vs. levo amphetamine... then chiral compounds are a mix of 50%/50% isomers. ((There are also chiral compounds with more than one point of chirality, their stereo-isomerism would make a normally occuring, racemic (evenly mixed isomers) compound 25%/25%/25%/25% is 4 isomers exist.)) But just remembering the 50-50 part, is enough.
Now about mescaline toxicity: I think this is basically because the doses are so high and it is just too much too handle for the liver. I don't know why exactly, for example a compound like phenibut or piracetam is consumed in multiple gram quantities by people, etc. I just heard it is.
Allylescaline being so similar to mescaline but more potent in the brain because of it's actions on receptors... based on limited information I would say it would not be expected to show analogous toxicity as mescaline to the liver. So how potent in action it is, is here irrelevant to how the liver handles it.
Remember NBOMe compounds: they are not free of toxicity, but what is nice about them is that in the brain they are so selective for receptors... but if a liver is mostly concerned with either chemicals that are toxic because of their poisonous structure or degradation products or because of the sheer amount of it overwhelming and flooding it, then NBOMe's having such a low dose is in all probability a good thing as far as the liver goes (and kidneys as well).
Eating too much salt, using too much GHB (and the sodium ingestion that comes along with it)... that's an example of how everything can be a disturbance (toxic) to the body as long as the amounts are high enough to have effects of certain bodily functions. So as a rule of thumb: lower doses of things are better for the organs.
But for NBOMe's problems can come from their still being active and the causal consequences of the activation of receptors which is why they are still to be considered with much care.
So back to allylescaline and mescaline: if mescaline toxicity has little to do with what happens in the brain after taking it but more with the amount of milligrams that have to be metabolized and we have no reason to think that allylescaline is any differently, then it does not bear the same type of risks. However for all we know, the action of allylescaline on receptors can have quite different toxic consequences for the body... or the presence of that allyloxy group might be a problem, coming from metabolism of the group to a toxic breakdown product.
In other words toxicity of AL is a question mark but I did not mention mescaline toxicity to warn you about going to 150 mg with AL.
What I am just wondering about is how fantastic mescaline can get before it becomes a liver issue. Well 750 mg would be more than double than my 330 mg, but no idea what that means. It all depends on the dose-response curvature. Which is what I was asking about... does it feel linear like with LSD or steep like with 2C-E? Anyone with high dose mescaline experience is still welcome to fill that in for me.
Anyway sn23: sorry if I stepped on your point, I see I repeated some things you already explained or mentioned.
Today is my 29th birthday so I'm thinking about taking 100 milligrams of Ally and the last of my MXE this evening and hitting the water for some early morning fishing on the comedown.
What have been your previous dosage trials with Allylescaline and what does you want to make your dose 100 mg other than it being your birthday? Happy birthday to you, in advance.

But if you are in fact tripling your dose without there being information about the results, I just want to warn you that this is an irresponsible plan, ranging from potentially unneccessary to potentially dangerous.
Of course the entire 'range' of potential does include positive results, if it turns out that way: enjoy it.
But:

Then again, around 50 mg seems to be okay and it does sound gentle so may I am overreacting.
I'd just rather see this community taking steps of +15 or +20 mg instead of doubling. Act responsible.