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Tryptamines The Big & Dandy 4-HO-DPT Thread

can anyone refer me to any literature in regards to IV dosage? i have access to this compound and am decidedly swayed by reports of near intolerable taste via insufflation/oral ingestion.

have any members had success w/ (presumably lower) IV doses of this material? would it be safe to assume it is equally water-soluble, or similarly to other 4-HO/4-AcO-tryptamines (HCL is marginally soluble/free base is not)?? any insight would be greatly valued.
 
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^ The taste isn't so bad - it's bitter, but not bitter enough that it should dissuade you from insufflation. Plus, it's really gentle on the sinuses, not harsh and caustic like its cousin DPT. Some people have tried the IV route, but failed because it apparently was difficult to dissolve in water. My recommendation: just sniff it.
 
@TxAxCx -
thanx for your input! it is much appreciated. that was also a legitimate concern of mine (if insufflation culminates in the HORRIBLE burning, shooting pain i've unfortunately experienced w/ other compounds of chemical relation).

is there a ROA/bioavailability chart for this one or no? if one was to consume their dose orally, how long might it take for onset to be expected?

apologies for all the inquiries; as you may well know, there is not a great deal of documented literatute existing on it. in any event, preparation prevents potential problems! ;)
 
Getting 4-ho-DPT fumerate into solution for IMing

I finally acted on Sekio’s sage advice from months ago in a different thread to just try “boiling the hell out of it” to get 4-ho-DPT fumerate in solution for IMing. It mostly worked. I could have easily got the 35mg in 2 mL but I wanted to see how far intense boiling in 90 units (0.9 ML) of sterile water and 10 units of 5% acetic acid could take it.

I put it in a tall test tube so it could boil violently without leaping out, and set the tube’s screw cap on top so that pressure could escape while confining a significant portion of the vapor to the tube. I started using my microwave’s lowest defrost setting (the tube is plastic). The longest I let it go for was 30 seconds straight. This got most of it into solution but I set it to full power to see what would happen. I boiled a little too long and, after spinning around in my living room like a lunatic with the tube at arm’s length to get the droplets condensed on the side to pool at the bottom, dumping it into a vial, and drawing the solution into a syringe, I found I had boiled off 40 units leaving 60 units 4-ho-DPT solution. I didn’t go through the work of properly quantifying what was left because I was burning daylight and had a nature-gasmic adventure in recreational drug abuse to get under way but after drying it out with a hair dryer it looked like maybe 5 mg was left. I dumped some vodka on it and swallowed it for what it was worth.

Judging by the subjective effects of the estimated 30 mg IM dose, IMing is an improvement in potency above insufflation of maybe 70 percent. Also, like DPT, the qualitative effects significantly benefit from the “hit me fast and all in one go” onset of IM administration over insufflation. I find 4-ho-DPT to have proportionally less ego dissolving and more sensuous, aesthetic-enhancing, and synaesthetic effects than DPT while maintaining some essential qualities (it’s closer to DPT than anything else, and I’ve tried over 15 5-HT psychedelics, including 4-ho-MPT, which is probably the next closest in my experience). I’ll probably use two or maybe even three 1 mL syringes next time to do a proper strong dose of 50 to 60 mg. I’m fairly confident from my 55 mg insufflated experience in the past that this dose IM’d will be enough to maximize 4-ho-DPT’s novel beneficial effects without venturing into ego death territory, which can get confusing and more difficult to integrate in a psychologically practical way (at this point of my psychedelic career I’m finding it more productive and prone to novel discovery to push experience within dissolved but not totally “de-patterned” ego boundaries).
 
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Getting an amount of this finally! Been wanting to taste this one for a long time! Can anyone give a dose range? I've seen nothing on it really besides a few posts and TR's , but if someone could as an example say 4-HO-DPT is active from 15mgs-100mgs, something like that, maybe include ROA as well to avoid any confusion! Thanks!
 
Help?!?! said:
Getting an amount of this finally! Been wanting to taste this one for a long time! Can anyone give a dose range? I've seen nothing on it really besides a few posts and TR's , but if someone could as an example say 4-HO-DPT is active from 15mgs-100mgs, something like that, maybe include ROA as well to avoid any confusion! Thanks!
You are not confused, 15-100mg insufflated is the range most have reported about. TheAppleCore noted strong effects at 26mg, but the majority seem to prefer 50mg plus (myself included). If you're like me 4-ho-DPT will operate at a more temperamental level than most psychedelics do. I find its subtleties in broad emotive scans rather than in focused heady plunges.
 
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I might attempt to follow your route and make a solution to IM, though I know it will be difficult, i'll probably only hit for 50mgs. If I can correctly create the solution do you think it would go well with some MXE mixed in? From the talk i've read of it and my love for diss's and psyches combined it seems like a good choice since I also don't have a huge supply of it. I'll probably make the solution 50mgs 4-HO-DPT/75 or so mgs MXE, i'll probably insufflate anywhere from 25-50mgs of 4-HO-DPT beforehand to get a feel, then a few days later IM the solution. Sound feasible to you(i'd say i'm pretty thoroughly experienced with a large range of psyches and some diss's, if you don't know much about me that is...!), also do you think 50mgs would be good for at least a fairly strong ++ for the 4-HO-DPT's end? If not i'll probably add a bit more 4-HO-DPT as I may not want to make another solution for at least now as I don't have a load of it and won't be purchasing anymore for the moment.

Also that little description of how it effects you sounds throughly interesting and has only heightened my excitement to test 4-HO-DPT!
 
^Yeah, 50 mg insufflated will likely get you to at least a plus two. As far as IMing you'll probably need at least 2 mL of light acid and water solution to get 50 mg to stay in solution at room temperature. Wait for the solution to cool after hard boiling because it may precipitate back out of solution and clog your syringe. MXE will probably be fine, especially with something like 4-ho-DPT. With headier psychedelics I find MXE's racy mania confusing and prefer ketamine by far. I personally wouldn't mix it with a dissociative, though. A lot of what 4-ho-DPT does for me happens on a sensuous level (enhanced textures and synesthesia), and so blocking signals from the body with a dissociative sort of undermines that aspect of it. It's by all means worth trying to see if you like it, though, assuming you're working with multiple doses.
 
^Yeah, 50 mg insufflated will likely get you to at least a plus two. As far as IMing you'll probably need at least 2 mL of light acid and water solution to get 50 mg to stay in solution at room temperature. Wait for the solution to cool after hard boiling because it may precipitate back out of solution and clog your syringe. MXE will probably be fine, especially with something like 4-ho-DPT. With headier psychedelics I find MXE's racy mania confusing and prefer ketamine by far. I personally wouldn't mix it with a dissociative, though. A lot of what 4-ho-DPT does for me happens on a sensuous level (enhanced textures and synesthesia), and so blocking signals from the body with a dissociative sort of undermines that aspect of it. It's by all means worth trying to see if you like it, though, assuming you're working with multiple doses.
I see a perfect response though given the user its not surprising, what sort of acid would you suggest and in what mixtures, 1ml of h2o mixed in with 1ml of the acid, or something like 1.5mls of h2o and .5mls of the acid. I'll probably follow your process and boil it to fuck, then drop like 75mgs of MXE into, micron it, then stab anyway incase the 4-HO-DPT wants to be a bitch and precipitate out back in the needle. It shouldn't be to hard, i'll just need to make sure to do it all fast and have everything needed ready to go at that point. I may not even IM the MXE as I may not bother purchasing anymore at the second but who knows. I don't have many doses but I have enough to play a bit, first i'll probably try 25mgs 4-HO-DPT/75mgs of MXE, so how they play with each other and all that, then move forward to 50mgs, unless i'm like TAC and get some crazed experience from a lower end dose, though as we all know that can happen at any dose at any time.
 
In my few attempts I've been using 1 part 5% acetic acid 9 parts water, but citric acid may be better. I'm not entirely certain what's really going on with the interaction of 4-ho-DPT fumerate and different acids so far as different combinations influence solubility, so it's up to experiment.

Time circumstances and lack of proper equipment prevented me from learning anything more specific unfortunately.
 
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In my few attempts I've been using 1 part 5% acetic acid 9 parts water, but citric acid may be better. I'm not entirely certain what's really going on with the interaction of 4-ho-DPT fumerate and different acids so far as different combinations influence solubility, so it's up to experiment.

Time circumstances and lack of proper equipment prevented me from learning anything more specific unfortunately.
Unfortunately that may be the same for me friend, though I will experiment a bit, for example i'll be using three mls water or maybe a tiny bit more, if boiling, wouldn't some water and such be lost anyways?
 
^Yes, if hard boiling you're going to lose substantial amounts of water unless you have a way to condense and reintroduce it.
What do you think would work best for this, container wise? I think I recall you using a plastic test tube on the lowest setting in the microwave, once or twice though i'm fairly stoned so...? Thanks for all the help?!? BTW!
 
Task completed. No microwave used, only a large spoon, probably six or so mls of water, 9 to 1 on acetic acid, and a nice Colibiri with a good strong jet flame. I would kept the solution pretty much at boiling then lightly added more heat with the jet flame to create the almost explosive(well yours probably did since you used the microwave!)super boil, would remove the flame almost immeaditately, give it another second or so to cool down, then did this process multiple times. It was agitating more than anything else just needing to hold the spoon in place for so long but oh well I eventually got 35mgs dissolved into about 1ml(thats what was left after boiling at least...). Probably give it a go to see where it takes me then formulate my next triage, something along the lines of 4-HO-DPT+6-APDB+2c-e+a bit of MXE in a solution.
 
^Nice. Yeah an adjustable flame and a proper boiling tube would be best. I started using the lowest defrost settings in the microwave, which may have worked if I had been more systematic about it, but it wasn't happening and I was running out of daylight for my hike so I ratcheted up the power and it nearly went kablooey.

In any case it's good to know it's possible to get 35 mg in ~1mL with enough patience. That concentration makes me think we can probably get a proper strong IM dose in two standard 1 mL syringes, which isn't too unreasonable.

That combo sounds pretty good. One of my all time favorites is IM aMT and DPT, whose general character I imagine the 4-ho-DPT and 6-APDB portion of that combo would share.
 
I find insufflation of this compound far superior to IM. It has a "synth psilson type come up" which I don't hate but it always leaves me panicked and confused for the length of the come up. 10mgs insuffed versus 35mgs IM was out of this world superior! Never even thought about IM'ing it or plugging again because the BA's for each ROA besides orally seem the same for the most part! Least to me! Astounding substance though, worth every penny! Just make sure to "buy bulk" for the discount you'll receive as once your out, you'll wanna order more immediately the first chance you get after you run out of your "initial stash!".
 
^Huh, that's weird, especially for a drug that seems to have some degree of absorption issues plugging (though maybe it's enzyme related). I'd think such a compound would be even stronger than normal by IM injection relative to insufflated. Glad you had a good time in any case. I think I'll still try IM since I've already put some effort into it. I also picked up some propylene glycol. I may try plugging a 9:1 propylene glycol: DSMO solution with 4-ho-DPT to see if there's an improvement relative to water since I already picked up the mix to try with salvia.
 
Oh it was believe me, but IM'ing 35-40mgs at once ended up leaving me in a "panic" state during the come up because of its similarity to "mushroom" come up, IM it hits so hard and fast. I IM'd the 35mgs on its own when I had no known psychedelic tolerance, and I went to the bathroom immediately after IM'ing it because I had to pee like a MF'er and when I was done I checked my pupils in the mirror and there was like literally no Iris left because they were so dilated which is rare for me most times except with higher end doses of substances. For you stick to IM for sure as I know for psyches atleast thats your preferred ROA, same with me, may try it at a much lower dose next time, 35mgs was just way to much for as 4mgs nasally gets me tripping absolute balls just by itself! PM me if you want to talk more in depth about my experience via IM as it was nuts stuff!
 
^4 mg nasally makes you trip hard? That can't be right if you were able to walk to the bathroom on 35-40 mg IM. Is it about double nasal potency as expected?
I wrote that quickly, I thank God itself if it somehow exists and all that shit for that 35-40 IM'er. I hate mushrooms, I hate 4-AcO-DMT, the only thing i've taken that contained the core mushroom pharmacopia I ever liked, hell I tried it once and once only at 12mgs orally, and i'd scream it from the tallest mountains this world has to offer "I absolutely fucking love synthetically made psilocin!" just as much I would about LSD, mecaline, and or DMT. That was from one singular trip, one and only all orally, all at once in a single gelcap. I've munched the most potent caps known to man, and eaten the highest doses of 4-AcO-DMT, but hated either, and I realized why, no one had even shown a perfect middle ground, where the waves met perfectly, the bliss was absolute, and the turmoil absolutely deafening, yet standing outside as rain poured down my face all I could feel was pure euphoria for existing, not ATM, or anyone point in time, or for ever have been anything, except myself, that was there at that moment being showered with rain as tears excavated my cheeks like their own spiraling torrents, as if the sky where crying with me ATM for everything I was, for everything I ever had been, and for anything I ever will be. Silence like that is only known to certain people as is, whether they've experienced mountains or molehills, or ate 75,000 Ablert Hoffman handmade 750ug per hit blotter's does. Its almost as those moments of time existed for you and you alone, as if every other human was sucked into a pocket dimension for the time you were experiencing your "moment of silence".

After reading this written by BloodShed I realized at once what had happened and why people like yourself only call 4-HO-DPT a "emotion changer/magnifier" thats simply all mushrooms are as well, their just packed together in such specialized amounts and so much, that it just all happens at once, which is were people like me come in, you can't out toke me on DMT, I mean maybe someone could because one of us would reach the "white out" space of DMT's high, but in a contest where we each had to inhale exact amounts of perfectly vaped DMT, in one hit, I wouldn't even be that scared to toss something like 150-250mg's out there as a starter. Thats not me dick sizing either, i've just smoked probably at least 25grams of DMT to myself in the space of a year............well you get it, i'm a bit of a nutter, no one has ever or will ever deny that one! No way in hell though would I go over 10mgs synth psilo orally, 35mgs 4-AcO-DMT and 3'gs average potency mushrooms.........., oh darn forget to post the quote oh well no time like the present, "With this one its less about the visuals and more about the visions. Less of an altered reality and more of a completely different reality.", you see thats why I fucking love DPT!!!!! Of course as well I love its four sub but let me put it into a better perspective for you, after I found the DPT/Ket/and or MXE IM'd or plugged at once!" thing, I easily could IM a 75IM MXE shot mixed in with anywhere from 50-250mgs of DPT in one shot. It actually got to the point that I hide the rest of my DPT because no one had bothered getting a synth done in a while and well I was beginning to run quite low obviously............

Anyways, I love DPT, I might not want to smoke it, but mainly becuase i've found smoked ROA's to be annoying and not at all worthwhile in simply tryps. Save those for IV/IM use when you can!;)

Oh and thats exactly what it was like when I pushed down the plunger, well I mean pulled out the needle/capped it/deposited of it!

Oh and lastly for future comparisons, walking is something I can do on anything, ask my friend who was promptly freaked the fuck out when I awoke from a knock out GHB dose(2.5-6.0 grams for me and I rarely pass out under 3.5)tried to get up, move around, and start to walk. He said he just grabbed me, laid me back down with something heavy ontop of me which he moved off from what he said like two seconds later as it was clear I somehow "snapped out of the g coma" came to and tried....IDK going to sit in my recliner? I'm also the sort of guy who needs serious doses of almost any normal alcohol or GABA like sedative to start tripping up, or falling over, or slurring my speech, thats when you know its time to get me into a bed, other things aren't go to so nicely! ;) :P

Reread my one and only IM ket report, you questioned how I was able to IM 175mgs of Ket with no tolerance, amongst a slew of other things, yet be able to pull up my pants, walk to the bathroom/put everything away, and take a piss/flushing before pretty much literally falling into my recliner and K'holing, lol I pretty much stumbled into/pulled myself into a seated postion, jacked up the footrest, and bam KKKKKKland!!!!!

Oh and 4mg weighed on a sub mg, put onto my "special" snorting tray and snorted through a straw, tapped, clenched the nostril to make sure none got past the goodie zone, then IM'ing MET HCl wouldn't make you trip hard.....?!?!?!?!? ;) Metlers have nice windshields even if their older in the years........;) 4-subs are weird for me BTW, some I need super high end doses to get anything, other times with like say 4-HO-MET, 10mgs can give me a full on +++ without trying........
 
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