Xorkoth
Bluelight Crew
Idk synthesized psilo is pretty rare, even then it wasn't even my main point
It was synthesized, pure 4-HO-DMT actually, there was a brief time in 2006 that some was synthed and made the rounds. I even said it was pure synthetic in my post that we're referring to.
I think it's just a bit of hubris to think that we completely understand all of what is going on with drugs in the brain, and how their interactions with our brains impacts the effects we experience. I think we have a pretty good basic understanding, but in, say, 100 years, we'll look back at now and see all the stuff we realized we got wrong, and see how incomplete a picture we actually had. I am pretty sure we don't have a complete picture at this point.
When you've taken psychedelics a whole lot, you notice the similarities among all of your trips on a substance, although yes, of course each trip is unique in ways, too. When you notice the same differences happening every time with 4-AcO-DMT vs 4-HO-DMT, and so do a ton of other people, to me it isn't proof that they are definitely different in their pharmacology, but it is evidence that points to a strong possibility that they are have differences.
I'd love to get a double blind test going among a statistically significant number of people with sufficient experience with both substances, and see how many were able to correctly identify each substance, and put this matter to rest.