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Tryptamines The Big & Dandy 4-AcO-DMT Thread - Act Five

For what it is worth I had 20 mgs of 4-ACO-DMT powder which was white and it was just kept in a folded piece of paper. It was forgotten about on a dresser in a cup for 5 years. I mean that was almost open air. It was still white and as good as new. Freezer even better but this was forgotten about.

It appears the 4-ACO-DMT fumarate is stable for a long time even at room temp. It would be interesting when someone says they have 40 year old fumarate. But crazy how some other forms turned black quickly when it came out But it was said it was very strong still. I think that was the HCL?? Not sure.
 
4-AcO-DMT has been confirmed to be a psilocin prodrug in the body: In vivo validation of psilacetin as a prodrug yielding modestly lower peripheral psilocin exposure than psilocybin .
Now the question is: is psilacetin psychoactive on its own? It crosses the brain blood barrier (unlike psilocybin), and despite having 10 times less affinity for the 5HT2B receptor than psilocin, it seems to have some activity. Maybe the differences that people notice between psilocybin and psilacetin are due to 4-AcO-DMT activating the 5HT receptors as both 4-AcO-DMT and its metabolite 4-HO-DMT, unlike psilocybin who can't cross the BBB so only its metabolite 4-HO-DMT binds to the 5HT receptors.
 
cosmic charlie said:
It is better than Mushrooms in many ways, tho i love both of those substances quite a bit. Find the visuals of Psilacetin to just be on a whole other level and be very similar to those of DMT. The second portion of the trip when you are about halfway it turns into some of the purest euphoria you can imagine. I always get an afterglow from it that is just magical, like the world is just the most beautiful thing ever.

It’s a remarkable antidepressant. The comeup on large doses can be really intense tho and it can rattle you a bit but that always flips around into bliss for me. Mushrooms are great to but they sometimes have a bodyload that comes with them i just dont get from 4-AcO, and i assumes that comes down to the fact you are consuming a pure compound and not the actual Mushrooms.
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Just finished reading your post and i totally agree with what you’ve described! I had only one prior experience with this substance at roughly 25mg dose and with my second experience i decided to take 40mg and holy shit within the next 20mins i was off my rocker with my short term memory shot for the next hour causing i believe a delusion on me bleeding from my nose and looping thoughts but after the first hour i was able to recover and it indeed flipped into a wonderful trip still with strong visual effects for the remaining trip. But man that initial hour after the t+20m I’ve lost all sense of time completely out of it

Do want to go back to back days might dose at 30mg the tike around.
 
Has anybody here noticed peculiarities about psilacetin cutting through tolerance? I'm only a couple days past 3mg of DOB, I've drank maybe 70-100mg of 2C-B in the last two days, there's even carisoprodol, tapentadol, THC-P, ∆9 THC, kratom leaf, tizanidine and caffeine actively in my system but an impulsively popped capsule containing 15mg of psilacetin did work as if there was no tolerance at all. Maybe this is due to it being indolic whereas I've been predominantly using phenethylamines? I have no clue but would love to hear other peoples' subjective takes on capacities to redose this drug and especially info pertaining to cross-tolerance.
 
^I've noticed it doesn't build much tolerance. A few days without is enough to reset it. Redosing during the experience is worthwhile in my experience. Really crazy stuff.
 
Cream Gravy? said:
^I've noticed it doesn't build much tolerance. A few days without is enough to reset it. Redosing during the experience is worthwhile in my experience. Really crazy stuff.
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Excellent, thank you for the information! I've found N-benzylated phenethylamines to respond similarly where they can be redosed but only while still in the trip.
 
Esperighanto said:
Excellent, thank you for the information! I've found N-benzylated phenethylamines to respond similarly where they can be redosed but only while still in the trip.
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Yeah it depends on your tolerance at that point. If it’s my first day tripping I five days a redoes one to three hours in is definitely felt, really helps extend the experience and sometimes intensify the trip.

If I dose multiple days in a row the dose response curve gets steep but I have so much of this stuff on hand that I pop it like candy when I’m bored with a bit of booze and kratom usually.
 
psychetastic said:
4-AcO-DMT has been confirmed to be a psilocin prodrug in the body: In vivo validation of psilacetin as a prodrug yielding modestly lower peripheral psilocin exposure than psilocybin .
Now the question is: is psilacetin psychoactive on its own? It crosses the brain blood barrier (unlike psilocybin), and despite having 10 times less affinity for the 5HT2B receptor than psilocin, it seems to have some activity. Maybe the differences that people notice between psilocybin and psilacetin are due to 4-AcO-DMT activating the 5HT receptors as both 4-AcO-DMT and its metabolite 4-HO-DMT, unlike psilocybin who can't cross the BBB so only its metabolite 4-HO-DMT binds to the 5HT receptors.
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Yeah its active by itself - its only a bit like mushrooms at lower dose at higher doses 60-350mg its oral DMT.
 
Cream Gravy? said:
Yeah it depends on your tolerance at that point. If it’s my first day tripping I five days a redoes one to three hours in is definitely felt, really helps extend the experience and sometimes intensify the trip.

If I dose multiple days in a row the dose response curve gets steep but I have so much of this stuff on hand that I pop it like candy when I’m bored with a bit of booze and kratom usually.
Click to expand...
Dude! It’s been a minute. How are you?!
 
Ismene2 said:
Yeah its active by itself - its only a bit like mushrooms at lower dose at higher doses 60-350mg its oral DMT.
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Ime the duration of the trip is very similar to mushrooms.
However the bodyload is alot cleaner and similar to white DMT xtals.
Although its still a heavy bodyload but in a nice stoning way.
Same with visuals being alot more like DMT compared to mushrooms.
 
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