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Dissociatives The Big & Dandy 3-MeO-PCP Thread: 3-MeO 4 Leaf Clover

My bad - I was waiting to see those results come back, very confusing indeed.

Original batch was the floury, fluffy, white clumpy powder, newer one I've got is slightly more tan and crystalline/granular and has more of an odour/taste.

Mystery goes on.
 
Are most batches these days the less manic version of 3-MeO-PCP or is there an equal opportunity to get either batch at the moment, in general?
 
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@Bella Figura - The only stuff i've ever had is much more hypnotic (is that the right word?) and psychedelic than it is stimulating.
When people started reporting there were different batches, it all started to make sense to me.
Previously i was questioning whether it was the same substance - the duration of action and potency were the same, but the effects i got were very different.
Pretty fascinating.
 
Yeah I've got both... the more dissociating one is white white and has an almost sweet mixed with clinical smell when I snort it. It also makes me sneeze quite a lot compared to the other batch. The other batch is more stimulating and manic, very light tan, and it smells a lot like cocaine when I snort it. Or rather, something about that initial wave of scent/taste reminds me of cocaine. As stated in the last page, both test via GC/MS as containing only 3-MeO-PCP.
 
Spacejunk, it sounds like what I've tried recently is what you've had all along. Strange days!

Xorkoth much respect and gratitude for getting those tests done <3
 
Yeah I've got both... the more dissociating one is white white and has an almost sweet mixed with clinical smell when I snort it. It also makes me sneeze quite a lot compared to the other batch. The other batch is more stimulating and manic, very light tan, and it smells a lot like cocaine when I snort it. Or rather, something about that initial wave of scent/taste reminds me of cocaine. As stated in the last page, both test via GC/MS as containing only 3-MeO-PCP.

So, you have two batches supposedly containing only one and the same molecule but they look, smell and feel different? How do you explain that? I'm really curious. I mean, do think the tests missed something or do you just like have no real clue what the hell causes the difference (cause I truly don't)? I read the whole thread and this batch-topic really got me because it very much opposes my (scientific) view of how things should be ^^
 
I don't know how to explain it. I trust the guy who did the GC/MS, a capable and intelligent (and learned) individual. Myself and all my friends agree the batches have different effects. They're both clearly 3-MeO, but one is sparkly and dissociating and not manic, and the other is stimulating and manic. I have no idea why. The color can be easily explained by a minuscule leftover side reaction product (even an insignificant level of something leftover from synthesis can produce color), might also explain the smell, but the GC/MS only had 1 peak on each, and it was the 3-MeO-PCP peak.

It's a mystery. The fact is, we don't have the whole picture when it comes to drugs and how they work in the brain and the resulting subjective experiences. We understand a lot but to claim we know it all is arrogant, IMO.
 
Going a bit offtopic, but could these subjective differences appear in other drugs, even common OTC ones like acetaminophen or ibuprofen? Maybe someone who works at the pharmaceutical industry could answer that.
 
Not necessarily placebo. It is known that generic or "bioequivalent" meds sometimes arent as effective as their branded version, even though the active substance is the same. Generally the cause seem to be binders and other stabilizers but honesty havent looked to much into it
 
There's a medication, I believe an HIV mediciation, that is polymorphic, and only one of the polymorphs actually works for its intended purpose. Someone linked to a research study about it in one of the MXE threads, which is where I heard about it, can't remember anything specific about it right now though. To me that suggests that polymorphism could actually have an effect on the subjective effects of a drug.
 
No, that study you linked talks about genetic polymorphisms, not about structural polymorphisms in the drug. I also remember there was as tudy on alprazolam polymorphisms and how they affected absorption. I'll have to look for it.

EDIT: I found this thought, the FDA definition of structural polymorphism:

http://www.fda.gov/ohrms/dockets/ac/02/briefing/3900B1_04_Polymorphism.htm



They do say that differences in the morphology of the crystal could affect stability and even bioavailiability, which makes sense to me. But the fact that the effect's vary wso much between batches seems difficult to explain just by differences in bioavailiability. I would expect only differences in potency. But, like I pointed out a couple of posts ago, differences in the dosing regime (Single high dose, vs small doses through the day, etc...) seem to have an effect in the subjective effects, and considering this molecule is already absorbed pretty slowly judging by it's long winded oral come-up, maybe is not that surprising that differences in bioavailiability and therefore absorption kinects would affect the effects to such an extent. Pretty interesting nonetheless.
 
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Maybe this stuff is so subjective that one would get a new batch, try it, and just by chance it's a rather non-manic trip and one automatically makes the batch responsible for it and then the rest is self-fulfilling prophecy and the whole batch will stay non-manic because one expects it to be non-manic...Well, I obviously find that highly unlikely, but it's just so freaking illogical to me that the same stuff would act differently. I haven't experienced any batch differences myself since I thoughtlessly mixed my batches. But I do recognize a change in effect over time and over situations. Sorry if this is a repeated question but what is the main difference? One batch stimulates and one sedates?
 
Still feeling quite flat days after use. Do we know what receptors these use and how to recover them? Just general eating healthy, good diet and exercise enough? I am picking back up, slowly. Exercise and meditation is helping lots.

I definitely found this stuff to be quite subjective. But i imagine it's a combination of dose, currently health, wellbeing, mood, exercise, diet, etc etc. I do think it's possible to have some at least minor influence on the effects according to expectations etc. The problem with this stuff is even with a 0.001g scale I think there can still be variances relating to amounts and because it takes so long to get out our system and tolerance I feel like there is a huge margin for error.
 
^ while this seems interesting, any such properties should be lost, when the compound is in solution. Furthermore, this article I found http://news.berkeley.edu/2017/01/26/scientists-unveil-new-form-of-matter-time-crystals/ says that you have to put in energy to make the thing do something in time, which is logical, because initiating motion (acceleration) without putting in energy is not possible.

All I know about chemistry and physics lets me doubt very much that this has any effect on the mechanism of auch action of drugs.
 
A time crystal is like constantly oscillating jelly in its natural, ground state, and that’s what makes it a whole new form of matter – non-equilibrium matter. It’s incapable of sitting still.

Those time crystals sound pretty manic...

But seriously, I don't see how it's related, and I'm still having trouble with the crystal polymorphism in solutions thing.
The only difference there should be in such a case is for dissolution rates which perhaps may make a difference for whether sublingual absorption or general absorption is rapid for favorable kinetics.

Snorting MXE is so different to oral IMO (seems more like ritalin to me that way than dissociative, at least up until a certain point), of course the main explanation seems to be first-pass metabolism difference between enteral and parenteral, another one could be the kinetics.

All that should be possible to negate by giving your material time to dissolve before taking it, like putting 3-MeO in water before taking it sublingually so that densely packed crystals have been given time to dissolve entirely. If that doesn't solve the different batch mystery, I don't buy that it could be polymorphism.

Those time crystals should lose any such property upon dissolution and how do you expect to pass into the brain and act on your NMDAR etc if it's not entirely dissolved? Also, I really don't think there are accidentally time crystals all over the place?

Just like with DMT etc it's not a good idea to suspect that there are fantastic and secret material / physical properties to a drug because of how astonishing it's actions are in the brain. It's belief that the substances would be astonishing in entirely different ways like that, but very dissatisfying an explanation to a pharmacologist I expect.
 
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Yea I have no idea how to draw the correlation but it's just a nice manic thought, lol

I'll try to explain my insane thoughts later, there's no way I can do it now
 
Haha true dat

Can't wait for you to share your insanity, is it infectious?
I thought your resolution was to cut back..

I myself am cutting back on even the tiny bit of 3-MeO i use, cause it really appears that my blood pressure gets way too high from the combination of dexamph, even though it's not on the same day. Let alone coming down from an incidental dose of a downer, which also elevates BP. I got popping blood vessels and stuff, it's no bueno. Actually no idea if that also means I shouldn't take DOM or TMA's, not many things have the long half life of PCP compounds.

edit to comment on below: it's not perpetual motion because that kind of motion is not the same as molecular motion. Any substance that is not at absolute zero temperature which is a mythical thing by the way will have moving atoms or molecules and it will have perpetually.
The motion mentioned for the time crystals seems to be a motion seen even at absolute zero, since it does not get it from the environment it seems to be a sort of motion that resonates through time. i think
Aside from the question how perfect zero was achieved, if a laser has to be kept firing then it's not strictly as I say, but I assume it was calculated to have that additional resonance.
 
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