samadhi_smiles said:
Also...the timeline (according to my experience) of rectal admin of phens does not match your graph. The only difference is the comeup and comedown are abbreviated. The peak itself is as long as oral administration as far as I can tell (perhaps a tad shorter, but nothing drastic). Albeit this is only experience with 2CB, 2CE, and methylone.
fourth position tryptamines are certainly shorter, they seem to basically come on, peak for a few minutes, then drop away (although I've only experimented with 4-AcO-DMT and some 4-ho-DMT with this). I'd like to compare rectal admin of these chems with vaporizing them (I believe there will be a winner vaporizing 4-AcO-DMT for very short and very intense DMT-like experiences).
The greatest issue in length of peak seems to be the amount of drug one takes (more and this results in a longer peak).
peace!
My only experience is with 2C-T-2 (once) and oxycodone (twice),
both of which had very rapid come ups (the drop off is more
noticable with a psychedelic).
The graph I posted is a comparison of intravenous (IV), extravascular
(EV), and then oral, which is subject to large fluctuations.
Extravascular is essentially intramuscular injection ... the drug just
has to diffuse from the tissues into the bloodstream to get to the brain.
Rectal and nasal mucous membranes constitute a very rapid
absorption surface that can approach that of EV, but are also
subject to some other factors. Any extra mucous in your nose,
or "stuff" in your rectum can significantly slow absorption. So for
these routes, the drug has to first get into the tissues, and then
migrate to the bloodstream. Also, rectal enema (fluid form) should
be very close to EV, where as suppository is almost closer to oral.
The bottom line is that the rate of absorption determines the
comeup and the rate of both absorption and drug metabolism
determine the full length. When the absorption is very slow as with
oral, the "plateau" increases significantly. When it is very rapid,
peak levels are reached quickly and drug metabolism becomes the
determining factor, which results in a much earlier decline from the peak.
To each his own I suppose. All I know is that I've found rectal to be
fairly useless since I like to have time to get comfortable with the
psychedelic state before it becomes really interesting.