If I remember correctly, most people that had success with this in the past used around ~120mg. The people that used 200mg were more likely to get into rough territory or experience cardiac side effects (although I remember one commenter that experienced cardiac side effects at 120mg.)
The comeup is really long slow, so YMMV with ketamine. What are you hoping for with the combo?
At 120mg (maybe just 100) I remember this drug feeling really lightweight until I finally got to the plateau, which ventured into a +++ for a while. I'm glad I didn't try to boost it with something longer lasting than ketamine. If the drug works for you (it's notoriously erratic) then I wouldn't describe 200mg as "a roll." That would be a full on, long duration trip comparable to LSD or DOC at peak.
What's the NAC for? Is it just a normal daily supplement? Or are you taking it to reduce oxidative damage like you would for MDMA? If it's the latter, you don't need to. There's no reason to think NAC causes oxidative stress in the brain in the way MDMA does. It doesn't make you dump serotonin into your synapses (part of why you roll.) It mimics serotonin in a warped way and makes you trip like mushrooms do (which are more or less nontoxic.) NAC can cause anxiety, stimulation, insomnia, hypomania, and stomach upset if you aren't habituated to it.
Tips:
- Take on a completely empty stomach. Encapsulate it and then swallow with zero water if possible (or a sip of some acidic liquid like lemon juice in water or orange juice if needed) to reduce the risk of dimerization destroying the drug.
- Start at 100-120mg if it's your first time, especially if you aren't a regular tripper and don't know how you respond to psychedelic phenethylamines. If you're looking for a rolly experience instead of a trip, aim lower at 80mg. Just be aware that you will be in for a long wait before you get to peak - it will not hit you over the head in twenty minutes like MDMA. If nothing happens, adjust the dose the next time. 200mg is where I would go if I wanted to trip HARD for looooooooooooooong time. I personally don't like the safety profile of this drug enough to be willing to push the dose, though. If I had access to something else that was safer and long lasting, I would personally take that instead to get that effect.