What he thinks of it may be very different from what he talks, and what he talks is nonsense anyway. Not only 2C-I-NBOMe is a 5-HT2A agonist with the pharmacological effects of a "psychedelic drug" active in man, but also a psychedelic in the classical meaning of the word, capable of inducing profound states of mind and dramatic experiences of significant spiritual and personal meaning. In my recent report on it (that can be found here) I ranked it with acid, mushrooms and DOM for a reason.Blowmonkey said:Do you have any idea why Nichols presumably thinks of 2C-I-NBOMe as something "not psychedelic"..?
These observations are too general to be instructive. Doses above one-two milligram(s) have produced ...some usual phenomena of an overdose mostly similar with that of any other psychedelic drug.Shampoo said:General consensus seems to be that 25I-NBOH shows no oral activity.
*Activity via sublingual or parenteral starts at well below one milligram (full activity at 500-700µg) and may be fatal in high doses.
*Doses lower than one milligram have reported some visual and cognitive activity, though reports are not detailed/well-defined.
*Doses above one-two milligram(s) have produced profound effects including severe confusion, disorientation, and overwhelming visual distortions.
*Doses of more than three milligrams may produce seizures and doses of less than ten milligrams may be fatal (shown in other n-benzyl derivatives).
Doses of more than three milligrams may produce seizures and doses of less than ten milligrams may be fatal. Reality is a little more complicated of course. One of the reports on worryfying overdoses I was able to find was about a man who took 1 mg of NBOMe-2C-I by insufflation. He literally fell as if shot five minutes later, lost consciousness and had seisures.
But I also had a memorable overdose if we are talking on that subject now. At the beginning of it all in 2007 I couldn't killed myself with 30 milligrams (this isn't a typo and was accurately weighed) of NBOMe-2C-B i/m, when accidentally mislabeled packages. I was able to return to this plane of reality unharmed, without any lasting consequences of this misfortune to speak about. There were several lethal doses in it - if we are to estimate them the proposed way. Nevertheless, I am alive and feeling fine, and I can't do anything about this fact. What's worse, I am not at all unique in being so tough. There is a number of reports about similar accidents found at several russian thematic web-resourses. Their story is always the same: someone accidentially overdoses with 5-10 mgs of NBOMe-2C-C/B/I, and after suffering extreme DMT-like trip gets off with only a scare. People like me or these others who won't die from what was called a "lethal" dose in the citation aren't a rarity, it looks more like this is a norm (or one of several norms to be more precise). For us who are the toughest ones in this regard, NBOMe molecules are nearly as safe as the least toxic structures among 2C-X PEAs (that seem to be the safest psychedelic phenylethylamines I am aware of).
This shouldn't serve as a cause for optimism towards phentanyl-like structures we are talking about here. There are also people, who are also quite numerous, for whom their safety margin appears to be closer to that of DOX. For them a suicide by means of 20x-30x NBOMe-2C-X overdose isn't necessarily impossible. And there are also individuals, not as numerous (but it makes no difference; that they exist is just enough), who will find NBOMe-2C-X to have the safety closer to that of benzodifurans like bromo-dragonfly (it would probably be better to say they have no safety reserve at all). These latter individuals will be the first to get into dangerous or even lethal accidents, if we are to see such in the near future.
While there is no way to find out beforehand who is who, or what may happen if somebody will take one of these chems.