• Psychedelic Drugs Welcome Guest
    View threads about
    Posting RulesBluelight Rules
    PD's Best Threads Index
    Social ThreadSupport Bluelight
    Psychedelic Beginner's FAQ
  • PD Moderators: Esperighanto | JackARoe | Cheshire_Kat

The Big and Dandy NBOMe-2C-C (25C-NBOMe) Thread

Blowmonkey said:
Do you have any idea why Nichols presumably thinks of 2C-I-NBOMe as something "not psychedelic"..?
What he thinks of it may be very different from what he talks, and what he talks is nonsense anyway. Not only 2C-I-NBOMe is a 5-HT2A agonist with the pharmacological effects of a "psychedelic drug" active in man, but also a psychedelic in the classical meaning of the word, capable of inducing profound states of mind and dramatic experiences of significant spiritual and personal meaning. In my recent report on it (that can be found here) I ranked it with acid, mushrooms and DOM for a reason.

Shampoo said:
General consensus seems to be that 25I-NBOH shows no oral activity.

*Activity via sublingual or parenteral starts at well below one milligram (full activity at 500-700µg) and may be fatal in high doses.

*Doses lower than one milligram have reported some visual and cognitive activity, though reports are not detailed/well-defined.

*Doses above one-two milligram(s) have produced profound effects including severe confusion, disorientation, and overwhelming visual distortions.

*Doses of more than three milligrams may produce seizures and doses of less than ten milligrams may be fatal (shown in other n-benzyl derivatives).
These observations are too general to be instructive. Doses above one-two milligram(s) have produced ...some usual phenomena of an overdose mostly similar with that of any other psychedelic drug.

Doses of more than three milligrams may produce seizures and doses of less than ten milligrams may be fatal. Reality is a little more complicated of course. One of the reports on worryfying overdoses I was able to find was about a man who took 1 mg of NBOMe-2C-I by insufflation. He literally fell as if shot five minutes later, lost consciousness and had seisures.

But I also had a memorable overdose if we are talking on that subject now. At the beginning of it all in 2007 I couldn't killed myself with 30 milligrams (this isn't a typo and was accurately weighed) of NBOMe-2C-B i/m, when accidentally mislabeled packages. I was able to return to this plane of reality unharmed, without any lasting consequences of this misfortune to speak about. There were several lethal doses in it - if we are to estimate them the proposed way. Nevertheless, I am alive and feeling fine, and I can't do anything about this fact. What's worse, I am not at all unique in being so tough. There is a number of reports about similar accidents found at several russian thematic web-resourses. Their story is always the same: someone accidentially overdoses with 5-10 mgs of NBOMe-2C-C/B/I, and after suffering extreme DMT-like trip gets off with only a scare. People like me or these others who won't die from what was called a "lethal" dose in the citation aren't a rarity, it looks more like this is a norm (or one of several norms to be more precise). For us who are the toughest ones in this regard, NBOMe molecules are nearly as safe as the least toxic structures among 2C-X PEAs (that seem to be the safest psychedelic phenylethylamines I am aware of).

This shouldn't serve as a cause for optimism towards phentanyl-like structures we are talking about here. There are also people, who are also quite numerous, for whom their safety margin appears to be closer to that of DOX. For them a suicide by means of 20x-30x NBOMe-2C-X overdose isn't necessarily impossible. And there are also individuals, not as numerous (but it makes no difference; that they exist is just enough), who will find NBOMe-2C-X to have the safety closer to that of benzodifurans like bromo-dragonfly (it would probably be better to say they have no safety reserve at all). These latter individuals will be the first to get into dangerous or even lethal accidents, if we are to see such in the near future.

While there is no way to find out beforehand who is who, or what may happen if somebody will take one of these chems.
 
although the doses are far lower, the prices seem so much higher that they cancel each other out

thus the main thing to consider is whether the experience is really different enough or interesting enough
 
What he thinks of it may be very different from what he talks, and what he talks is nonsense anyway.
I'll agree on that. =D I thought it was funny when I was pointed towards that video by someone. I first thought it was the DOI version he was talking about (as that one's rumoured to be inactive), then perhaps 2C-I-NBOH (I'm not good at recognizing structures obviously) but it was pretty apparent it was 2C-I-NBOMe he was talking about after 20 times replaying it.
 
What he thinks of it may be very different from what he talks, and what he talks is nonsense anyway. Not only 2C-I-NBOMe is a 5-HT2A agonist with the pharmacological effects of a "psychedelic drug" active in man, but also a psychedelic in the classical meaning of the word, capable of inducing profound states of mind and dramatic experiences of significant spiritual and personal meaning.

Eh... He's been studying psychedelics since 1969, I don't think I've ever heard him talk about anything zany like say, McKenna. Maybe he or someone he knew assayed them orally, didn't find activity and dismissed it. Shulgin himself generally only bothered to assay compounds orally.

Which video are we talking about?

There's a neat interview from him there: http://www.youtube.com/watch?v=64zZqkKLUGs
 
If he was doing discrimination studies it's very well possible the rats may think that the NBOMe compounds exact a different action than LSD (rats can respond strangely).

Perhaps a perceived lack of activity in the rat and a lack of oral activity in humans led him to this conclusion. I'm guessing he's not terribly interested in layman examination of the myriad chemicals he's investigated so maybe didn't come across the bioassay results posted around here.
 
I'm pretty sure i read somewhere that the 25X-nBOMe's (can't remember which ones specifically, know 25I was among them though) elicited the "head twitch" that usually correlates to psychedelic-ish activity in humans, can't find the link at the moment though... will post it if it turns up.

Also, anyone have any more info on the N-2-hydroxybenzyl or N-2-methoxy tryptamines? Read the Heim paper, but the info there was a bit limited.

Still waiting to give the 25C another go. Think i'm pretty settled on the insufflation route. What all doses have you guys tried via that ROA?
 
Last edited:
I'm pretty sure i read somewhere that the 25X-nBOMe's (can't remember which ones specifically, know 25I was among them though) elicited the "head twitch" that usually correlates to psychedelic-ish activity in humans, can't find the link at the moment though... will post it if it turns up.

I'm sure they do, I don't recall seeing it published anywhere though.

I haven't watched the whole Nichols lecture yet that Blowmonkey posted, but at around 25:50 he says that 25I-NBOH is not hallucinogenic. Maybe he explains why earlier in the lecture? It seems unlikely that it wouldn't be to me, but I'm not sure anyone's talked about trying any of the NBOH's, NBMD's etc. - Erny!?

I missed this:

Shampoo said:
General consensus seems to be that 25I-NBOH shows no oral activity.

*Activity via sublingual or parenteral starts at well below one milligram (full activity at 500-700µg) and may be fatal in high doses.

*Doses lower than one milligram have reported some visual and cognitive activity, though reports are not detailed/well-defined.

*Doses above one-two milligram(s) have produced profound effects including severe confusion, disorientation, and overwhelming visual distortions.

*Doses of more than three milligrams may produce seizures and doses of less than ten milligrams may be fatal (shown in other n-benzyl derivatives).

... but is it actually the NBOH or is that maybe a mistake?
 
For what it's worth, I'm still alive after 1.5mg insufflated today!

TR forthcoming, but I would recommend taking less than this, as well as knowing for SURE the concentration of 25c in your solution. :)
 
What's the best/easiest (two different things, perhaps) way of preparing this for insufflation, if one doesn't have microgram scales? Is it okay to obtain the desired quantity by a combination of milligram scale measurement and dissolving in alcohol and then snorting the solution? Or would there be a better solvent than alcohol to use?
 
Of course there is much uncertainty but is there some sense to it that overdose risk is more idiosyncratic than DOX or benzodifuran overdoses. I say this because the activity range itself is wider and I haven't heard about very specific physical overdose phenomena with the NBOMe's like severe vasoconstriction or something like a heartattack from physical overstimulation.

Are NBOMe's more likely to produce central overexcitation, seizures indeed and even serotonin syndrome? Is it possible serotonin agonism is so potent and specific that this is where the problem lies with overdoses?
It doesn't make too much sense though why LSD is so physically safe compared to the NBOMe's though. The latter are still phenethylamine derivatives of course so I can very well just be totally wrong. Perhaps instead of relatively specific cardiovascular failure it is more of a global failure where strokes and embolisms and a lot more things become likely to be a cause of death.

Just speculating out loud... Erny let me look at some subjective information about 2C-N, which I have paraphrased and quote something. You mention nausea and sedation, while I don't mean to generalize these seem like secondary effects stemming from a bodyload that manifests itself a certain way, not always the same for everyone in every situation. Strong rushing sensations from top to bottom are another (random) example I can think of. Body loads can be very different qualitatively and quantitatively and be experienced as something positive or negative.
From the modest reports of 2C-N that I read I took away that the bodyload often sounded "difficult", and people call it weird like you do.

Some people sound like they expect quite nice things of DON but personally I would not want to take the risk taking a DOX with the same 4-pos group as 2C-N, with 2C-N having the reports that it has.
Similarly an NBOMe sounds like a particularly bad idea, but the potency may be a reason for 'peripheral' effects to be absent, if they are indeed the origin of bodyloads. DON may be more potent than 2C-N as well, but being an amphetamine that may make it worse again.
 
I'm pretty sure i read somewhere that the 25X-nBOMe's (can't remember which ones specifically, know 25I was among them though) elicited the "head twitch" that usually correlates to psychedelic-ish activity in humans, can't find the link at the moment though... will post it if it turns up.

Also, anyone have any more info on the N-2-hydroxybenzyl or N-2-methoxy tryptamines? Read the Heim paper, but the info there was a bit limited.

Still waiting to give the 25C another go. Think i'm pretty settled on the insufflation route. What all doses have you guys tried via that ROA?

Doses I've tried (all insufflated):

750 mcg
1mg
1.5mg
2mg

Higher doses have a speedier bodyload, more dissociation, and seem to produce longer trails visually. The comedown off doses 1mg and higher leaves me with 1-2 day strung out feeling.

Changes to my HPPD include more visual snow and an increased sensitivity to color contrast.
 
Also, anyone have any more info on the N-2-hydroxybenzyl or N-2-methoxy tryptamines? Read the Heim paper, but the info there was a bit limited.
Both N-(2-methoxybenzyl) and N-methyl-N-(2-methoxybenzyl) tryptamines were tested up to 40-50 mgs and were found to be inactive.

skillet said:
I haven't watched the whole Nichols lecture yet that Blowmonkey posted, but at around 25:50 he says that 25I-NBOH is not hallucinogenic. Maybe he explains why earlier in the lecture? It seems unlikely that it wouldn't be to me, but I'm not sure anyone's talked about trying any of the NBOH's, NBMD's etc.
NBMDs were mentioned it this thread earlier, their subjective potency aligns with Heim's data. NBOH-2C-I as I remember was the pioneer compound in earliest amateur experimentation, the first one to be found fully active via routes of administration other than oral. NBOH and NBOMe are subjectively equipotent, their effects aren't similar but often it is not easy to define the actual difference, or distinguish it from something unique to the trip, set and setting. I am only familiar with NBOH-2C-B.

And when people tried to take NBOMe and NBOH 2C-I orally, they sometimes felt threshold effects as a result of minor transbuccal adsorbtion, these effects were too weak for the chemicals to show themeselves as hallucinogens indeed.
 
Of course there is much uncertainty but is there some sense to it that overdose risk is more idiosyncratic than DOX or benzodifuran overdoses. I say this because the activity range itself is wider and I haven't heard about very specific physical overdose phenomena with the NBOMe's like severe vasoconstriction or something like a heartattack from physical overstimulation.

Are NBOMe's more likely to produce central overexcitation, seizures indeed and even serotonin syndrome? Is it possible serotonin agonism is so potent and specific that this is where the problem lies with overdoses?
It doesn't make too much sense though why LSD is so physically safe compared to the NBOMe's though. The latter are still phenethylamine derivatives of course so I can very well just be totally wrong. Perhaps instead of relatively specific cardiovascular failure it is more of a global failure where strokes and embolisms and a lot more things become likely to be a cause of death.

In the the 25B-NB thread in ADD from a few years ago Erny makes mention of some near fatal overdoses with some overzealous dosing with the 2C-I derivative I believe. Speculated as to be the pronounced adrenergic activity, which makes sense....I think the details were in post #38.

http://www.bluelight.ru/vb/showthread.php?t=388351

The whole thread is a great read, the first time I remember the N-benzyl PEAS being mentioned in ADD, and its great to see the ADD alumnis wrap their heads around it....and Erny delivering the goods:D
 
Sorry for asking this again, and I'm sorry if the answer is somewhere in this thread already, a search hasn't revealed anything...

1) Is alcohol the only (readily available) solvent for 25C-NBOMe?
2) Roughly how much alcohol would be needed to dissolve a given mass of 25C-NBOMe?
3) Is insufflating alcohol (in the quantities needed for dissolving a dose of 25C-NBOMe) a reasonable thing to do? Indeed, is it sensible to insufflate a solution at all, or is it liable to slip out of the sinus cavities and down to the stomach?
 
Dose, Effects and Side Efects

25C-NBOMe*HCl

Subject wore double layer of nitrile gloves and a basic cloth respirator mask for protection during handling.

Dissolved in alcohol to 20ug/ul, then applied to filter paper circles, dried and used buccal/sublingual. Subject feels that buccal absoption is potent and that there is no need for insufflating liquids or injecting.

Note: all trials took place in the course of a single week, and tolerance played a role in trials 2 and 3

trial 1 = 3 x 100 ug simultaneous

trial 2 = 1 x 625 ug

trial 3 = 5 x 100 ug simultaneous (this trial also included 10.6 mg gel-cap oral 4-AcO-DMT); followed by 2 x 100 ug @ t = +3hr; followed by 2 x 100 ug @ t= +4hr

subject [39yo male @235lb] didn't feel any discomfort, nausea, jaw clenching, twitching, need to change positions or symptoms of serotonin overload. In trial #3, BP and HR were monitored at 3 times: +3hr, +4hr, +5hr.

results:
T/Sys/Dia/HR

+3hr/138/89/85
+4hr/138/80/70
+5hr/136/82/60

Usual course of experience: Come-up with much energy over one hour, although no nausea, as mentioned. A very sugary sweet and non-threatening colorful plateau consisting of tons of that blueish neon "Avatar movie" color. Whirling dervishes of neon blue and pink. Not very introspective, but oh so pleasurable. Once: Lay in bathtub with led lights flickering about and warm shower coursing over subject's tan tien center... Subject just feels immense euphoria and intense swaths of pastels. Another: Discovered why people like some band called shpongle and danced time away looking out the balcony onto a snowy evening pierced with christmas lights. ~3hr Plateau followed by very smooth and gentle sinking back to earth. Never really arrive back though, and simply feel warm, refreshed, clearheaded and energized.

Subject wonders where this stuff was his whole life! It is as though LSD was recreated as a mentally unchallenging woosh of color and lift. There were a couple of hairy moments where the setting was disrupted by neighbors or delivery guy, but issues that could have resulted in the trips going bad simply did not.

Note on trial #3: Subject feels that 25C-NBOMe is the nitrous of psychedelics, and 4-AcO-DMT is what he calls a "Sleepadelic". So he sought to create a psychedelic speedball by combining the two's upper and downer effects (of course these are NOT really uppers or downers). As mentioned, this trial was scheduled for 500 ug 25C-NBOMe + 10.6 mg 4-AcO-DMT. The experience was not what subject was hoping for, and so he elected to increase the 25C-NBOMe to let it overtake the trip from 4-AcO-DMT hands.

I hope this helps educate folks about the workable range of this chem, and aids in harm reduction.
 
Last edited:
It doesn't make too much sense though why LSD is so physically safe compared to the NBOMe's though. The latter are still phenethylamine derivatives of course so I can very well just be totally wrong. Perhaps instead of relatively specific cardiovascular failure it is more of a global failure where strokes and embolisms and a lot more things become likely to be a cause of death.

LSD is a (relatively low-efficacy) partial agonist, NBOMe are very high-efficacy agonists. The exception is the NBOMe-2C-B-FLY which may or may not prove safer in overdose.

I have not experienced "scary" physical side effects from NBOMe-2C-C at any dose. At worst very high doses produced mild tachycardia which may have been from simple anxiety. For an NBOMe to have a lethal dose below a milligram would make it on par with the most potent synthetic toxin ever developed (VX); even carfentanil has a higher LD50 (due to an abnormally large therapeutic index of 10000!).

I have had success insufflating aqueous sol'n of NBOMe-2C-C.
 
Last edited:
Sorry for asking this again, and I'm sorry if the answer is somewhere in this thread already, a search hasn't revealed anything...

1) Is alcohol the only (readily available) solvent for 25C-NBOMe?
2) Roughly how much alcohol would be needed to dissolve a given mass of 25C-NBOMe?
3) Is insufflating alcohol (in the quantities needed for dissolving a dose of 25C-NBOMe) a reasonable thing to do? Indeed, is it sensible to insufflate a solution at all, or is it liable to slip out of the sinus cavities and down to the stomach?
Water is the solvent I used to IM it. Be honest, did you go and snort alcohol?

Nice report reformer: In what order did you take the 25C and 4-AcO-DMT? I could see 25C being problematic in combination with other psychedelics due to the rapid development of tolerance it's responsible for and it's possibly displacing the other psychedelics from 5HT2a due to its high affinity.

The psychedelics on the far right side of this graphic (thanks Dondante) might make interesting combos with 25C due to their 5HT1a affinity, though:
16246005.jpg
 
Top