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The Big and Dandy AMT Thread - 2nd incarnation

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I don't know if AMT will be a good candidate if what you're after is a subtle boost of dopamine. I find its effects to be by far predominantly serotonergic in nature.
 
Two questions:

Deterioration: Does it only deteriorate in air, or does light affect it aswell? I received mine inside two black baggies.

Tolerance: Whats up with this? How long is it until you can dose again feeling the full effects?
 
Deterioration - All chemicals pretty much, including AMT, deteriorate in the air, and in light, and in heat. So try to keep them away from all of these. AMT is more stable than most tryptamines I would say but it will still degrade over time.

Tolerance - I'd say you need to wait at least two weeks between doses to feel full effects, or longer. This is because unlike many other psychedelics, this one releases monoamines, and it takes you body a little time to replenish them. You can dose a lot nearer than that and still get good effects, but they won't be as good and not nearly as psychedelic as the first.
 
Deterioration - All chemicals pretty much, including AMT, deteriorate in the air, and in light, and in heat. So try to keep them away from all of these. AMT is more stable than most tryptamines I would say but it will still degrade over time.

Tolerance - I'd say you need to wait at least two weeks between doses to feel full effects, or longer. This is because unlike many other psychedelics, this one releases monoamines, and it takes you body a little time to replenish them. You can dose a lot nearer than that and still get good effects, but they won't be as good and not nearly as psychedelic as the first.

I'm currently taking 5HTP, L-tryosine and multivits daily, anything else I can grab to boost monoamines? Will probably be hitting this again this weekend.
 
I'm currently taking 5HTP, L-tryosine and multivits daily, anything else I can grab to boost monoamines? Will probably be hitting this again this weekend.

In addition: What about adding MDAI to aMT? Proper stims are a pain in the ass to get at the moment, I haven't tried it but would it increase the euphoria, or just increase body load?
 
My £20 eBay specials have lasted well over a year and are still doing the job shockingly well. I even trust them to weigh out doses of 2C-E and the like where a mg or two either side can make all the difference cos they've never once let me down. Best. Investment. Ever.

My 0.01 scales that I got from eBay are poor. I can't really trust them, despite using your trick of putting the tray on and but then not zeroing them.

I see a vendor has 0.001 digital scales for £20 so i'm going to get them so I can be sure of doses.
 
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Yes, if the preponderance of reports indicates that combining SSRI's with MDMA or meth dulls the experience of both, there is reason to believe the same would be true of aMT. The big difference is that aMT is also an agonist at the 5HT2a receptor. So, assuming the aforementioned analogy holds for your girlfriend, she would probably still trip, but the euphoric effects of aMT would probably not be as prevalent for her as for the average non-SSRI user. If she's looking for a straight psychedelic experience, in my opinion there are better candidates than aMT.

While your reasoning is sound, I'm not sure if the case pans out completely. aMT actually has a higher binding affinity at SERT than either methamphetamine or MDMA. It could be that aMT's affinity is high enough to cut through the activity of many SSRIs. I would say that SSRIs are at least less likely to inhibit aMT's activity than they are to inhibit MDMA's (depending on the particular SSRI's selectivity and binding affinities). Also, the methamphetamine contrast isn't that useful, as its activity at 5ht is significant but minor.

Although it's been called into question, as I understand it, with my limited knowledge, the prevailing theory is that neurotoxicity is inevitable given simultaneous release of dopamine and serotonin in the same areas of the brain.

This is true, but it really depends on the quantities of the 3 monoamines that are released. Methylone and 4fa, for example, have been demonstrated non-toxic (using MDMA as a comparative model, and of course high-dose injections in rats). In general, strong peak effects where a lot of dopamine and a significant amount of 5ht are released tend to elicit the most neurotoxicity, as is demonstrated by methamphetamine. But do methylone and 4fa throw doubt on this seeming trend?

ebola
 
Here's your Starter for ten, fingers on buzzers... "What current theories are there as to the mechanism in which Alpha Methyl Tryptamine acts on the body to produce nausea and, in light of which, what drug might be effective with which to treat it?"
 
Here's your Starter for ten, fingers on buzzers... "What current theories are there as to the mechanism in which Alpha Methyl Tryptamine acts on the body to produce nausea and, in light of which, what drug might be effective with which to treat it?"
Like other psychedelics, it may hit the 5-HT3 receptor, whose activation is correlated with anxiety and nausea. It also releases and blocks the re-uptake of serotonin, and so the sudden surplus of serotonin may itself activate those receptors and cause nausea. So you want a 5HT-3 antagonist like ondansetron.

In other news, I’ve been having an incredible night on 14 mg aMT IM, 60 mg MDAI, 60 mg mephedrone, three 4 mg bumps of Adderall, a few 1 mL squirts of GHB, unknown low dose bumps of ketamine, and some puffs of jwh-018. Yeah, I decided to go balls out. That’s because last night I had one of the most terrifying and significant experiences of my life. (Read here if you’re interested).

I would have expected to have an amazing time on the drugs listed above no matter what, but having just been through something so terrifying and significant the night before gave the night heavy spiritual momentum. I resolved to undertake a number of projects and outlined plans I hope will aid in expanding my mind, help others, and maybe even make me some money.

Life is beautiful. It’s all about orienting your perspective with your spiritual beliefs, physical body, intellectual interests, and actions in the world. Psychedelics can help. Now go self-actualize people! Wheeeee!
 
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gonna oral dose some amt, will be smoking weed for the duration of being high, anywhere on BL are there trip reports with varying doses?, any help will be appreciated:)
 
Got some more aMT coming in tomorrow , and might be acquiring some meph for the mrs as for some reason she really enjoyed the stuff...

Was just wandering if its safe to combine the two? I wouldn't want to waste my aMT but she seems interested in the combo.

Any thoughts?
 
Do you guys think it would be safe to mix meclizine with aMT for its anti-emetic effects? since aMT is a mild MAOI and i cant find much information about meclizine, cheers! :D
 
Got some more aMT coming in tomorrow , and might be acquiring some meph for the mrs as for some reason she really enjoyed the stuff...

Was just wandering if its safe to combine the two? I wouldn't want to waste my aMT but she seems interested in the combo.

Any thoughts?

Not a terrible combo, but you might want something a bit more stimulating than meph (depends on dose of course!).

Personally, I find something like a small dose of molly about 5 hours in to be perfect.

Meph should be fine too though, I'd just worry about the compulsion to redose, meaning essentially, you'll overpower the aMT.

Maybe a bombed 100mg each of meph, no more, would be fine.
 
I'm on the end of a quick intense 2C-I trip but so over stimulated I can't get no sleep.

I was thinking of maybe making things interesting with AMT now, bad Idea after 2C-I?

Also how is AMT HCL preety much ineffective smoked? I'm thinking of trying to convert it to freebase but I have no idea how. I used to find it was easy to get my freebase AMT batches of the past to be converted into salt form but I can't find a method of going back.
 
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I'm on the end of a quick intense 2C-I trip but so over stimulated I can't get no sleep.

I was thinking of maybe making things interesting with AMT now, bad Idea after 2C-I?

Also how is AMT HCL preety much ineffective smoked? I'm thinking of trying to convert it to freebase but I have no idea how. I used to find it was easy to get my freebase AMT batches of the past to be converted into salt form but I can't find a method of going back.

I would avoid aMT in your current situation. Can't tell you why, it just feels very wrong!!

Yeah, you can't smoke HCL. Best ROA with the HCL is up your gary glitter. No nausea, and slightly more pronounced come up. It's mainly a euphoric stimulant at lower dosages. 50mg - 60mg is where the visuals really start to kick in, but I still wouldn't describe the latest batches as being amazingly psychadelic. aMT is quite forgiving in that way.

Don't you have a benzo or similar? That would go very nicely now in a small dose - enough to keep you awake and enjoy the trippy ending of the 2c-i without the stimulation.
 
Got some more aMT coming in tomorrow , and might be acquiring some meph for the mrs as for some reason she really enjoyed the stuff...

Was just wandering if its safe to combine the two? I wouldn't want to waste my aMT but she seems interested in the combo.

Any thoughts?
This question was addressed in this thread a few months back. Basically you're dumping a lot of monoamines so it's probably more damaging than either alone and perhaps a serotonin syndrome risk. I've done it with low doses of each to good effect (see a few posts up). Just go slowly and keep the doses of each low to moderate.
 
I would avoid aMT in your current situation. Can't tell you why, it just feels very wrong!!

Yeah, you can't smoke HCL. Best ROA with the HCL is up your gary glitter. No nausea, and slightly more pronounced come up. It's mainly a euphoric stimulant at lower dosages. 50mg - 60mg is where the visuals really start to kick in, but I still wouldn't describe the latest batches as being amazingly psychadelic. aMT is quite forgiving in that way.

Don't you have a benzo or similar? That would go very nicely now in a small dose - enough to keep you awake and enjoy the trippy ending of the 2c-i without the stimulation.

No phenazeham or anything on me, no weed either, thats the thing 2c-I stimulation is annoying, i dosed on AMT like a fool, really wish I could have smoked it though.

I took 70mg of AMT because I'm fairly experienced with it, I never found it anything like MDMA in my opinion in low doses, only on a few occasions i felt more social/ Also always felt AMT euphoria was more fluid which I liked, MDMA always feels like false love for me.

Any idea of converting HCl to freebase?
 
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