The one and only time I did this was on an hour and a half drive to a show. Driver was completely sober, but me and the three other passengers took some acid. In the middle of the drive a huge snow/ice storm hits, at some point the car spun out of control and did a couple donuts right in the middle of the fucking interstate before somehow coming to a stop facing forward, and still on the road and not in the ditch, and miraculously there were absolutely no other cars around us. We realized that we were all alive and simply had to continue going forward. We were all peaking during this, and it was one of the scariest, most surreal moments of my life.
This set off a flurry of nervous and negative emotions in me leading to a rollercoaster of a trip, amplified by unrelated tension amongst some of us for various reasons, culminating several hours in into one of the worst nights/trips of my life.
Never again will I take anything in a car.