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Bupe Suboxone/Buprenorphine FAQ & Megathread v3; 2010 - 2022

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CJWillis1986 said:
I have a very specific question. Before I ask, and before you answer, let me explain.

I HAVE SEARCHED THE FORUMS AND ALL SPECIFIC RELATED THREADS EXTENSIVELY!!
So PLEASE DO NOT answer my question with a link to a thread, UNLESS you know for absolute FACT that the answer to my question is in that thread. So, my question is...

I've been injecting the white round Subutex, but I can't really get them to dissolve really well. I always have to take my shot, then keep redoing whatever is left in the spoon until its finally gone, because it wont all dissolve at once for some reason.

So does anyone know how to COMPLETELY dissolve Subutex PILLS (White round generics) for injection??

I've heard of vinegar, but haven't tried it yet, because I don't wanna take it as gospel. Plus I've read in the injection safety manual that vinegar may not be best for your veins. I dont know of any other liquids people use for injection. I also heat my solution, which requires me to add more water than I'd like, but it doesnt matter, half of the medicine is still in the spoon afterward and the chunks are too big to get into my syringe. Because of all this medicine being left over, AND because of the heat, I start off with over 200 CC's of water, so NO, I do not need more water, that is not the answer to my question. I see everyone else on the forum talking about injecting their Subutex pills with no problem whatsoever, and I'm wondering how this is, and how nobody else has had the same problem as me. Atleast a couple of you have to know a solution to my problem.
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You need to read up on how to micron filter; otherwise it's not safe to inject tablets at all.
 
I have read Captain Heroin's FAQ on micron filtering. I already know this.

Update: Wow, I did not realize you ARE Captain Heroin until after I posted. Anyway, thanks for the tip. I read your stuff on Drug Forums, and then immediately after realized you are a Blue Lighter as well. Good stuff, it helped me alot.

However, I still don't have the answer to my question.
 
down508 said:
everyone ive talked to hates the strips, but I think they snort them (idiots). can anyone give me some advice? I rarely shoot them (4 times a month) but when I do I love the feeling of 2mg i.v., especially if my tolerance is low from taking 2mg in the morning and 2mg at night.

does anyone else notice that the effects you get from suboxone are pretty erratic? If I do 2mg one day and 2mg the next day I could feel high as shit the one day and not feel anything the next day, just normal. I see no real pattern, just good effects on some days none on the other. been on em for 18 months but cut back from 16mg a day to 4.
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I fucking hate the strips. In less than a month of 3x daily 8mg strip dosing I wound up with what I believe to be canker sores(?) under my tongue. Underneath my tongue my mouth is all swollen and raw, hurts to talk and burns like hell when I put on another strip. Not as bad as Cold Turkey, but no fun at all. Especially at the price those fuckers charge.

I read on Opiophile many people were having the same problem and some guy came up with a great solution (literally, "haha"). Take a saline nasal spray bottle and dissolve strips into it, shake it the fuck up and then just squeeze and sniff. I put 5 or 6 strips in the bottle and it after 2 days it's not even half empty. Plus my tongue sores are going away with a quickness.

[EDIT] Yes, I have noticed that bupe is super inconsistent. Some days I take my dose and get that nice warm glow (nothing you'd mistake with morphine, H or Oxy etc, but still, very pleasant). Other days I take the same dose and my bones are achey, it'll barely mask my WD symptoms. Very interesting medication, if I wasn't getting it for free through the Patient Assistance Program I'd flush the shit and get back on Methadone.
 
To those lovely people that asked: I was on it a very short time (comparatively) 4 months. I have been on methadone and subutex for longer periods in the past but the imminent arrival of my son required action!

I started on 12mg did a slow ass clinic taper to around 4.4 over those 4 months. then over 2 weeks I went down and jumped off at 0.1

Feel a lot better today (the last two were horrible, weed and benzos helped but not much at all) so I think the worst has gone. I have over 50mg sat right next to me as well! Not even tempted! (well sort of;))

I got 6 hours last night!!! Almost unheard of! Although very strong cider and xanax did help:D

Still got the RLS pretty bad, I get it in my hands the worst and that is subsiding. A swim if I can manage it today would work wonders I'm sure.

Funnily enough smoking crack helped as well.
I pray I never have to do this again but tapering is the way to go! Cold Turkey: FUCK OFF!!!!

Be lucky people. Much love from London
 
Try gabapentine or Lyrica for the RLS. That's awesome though man..I'm trying to plan a way right now to switch from methadone to suboxone (and then to nothing), but first I got to come up with the rent money lol.
 
Yes, I have noticed that bupe is super inconsistent. Some days I take my dose and get that nice warm glow (nothing you'd mistake with morphine, H or Oxy etc, but still, very pleasant). Other days I take the same dose and my bones are achey, it'll barely mask my WD symptoms.
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You can see videos about this, maybe on youtube, or at a suboxone site. But a doctor basically explains that you get high off of Suboxone, but eventually you hit a ceiling, and you can only get so high, and then after that it doesn't work its magic on you anymore.
 
So I'm a (rare) opiate user with little to no tolerance. I'm going to be getting my hands on a single 8mg sublingual film of Suboxone. Now I did reading and heard it's easy to divide the film into more accurate doses, for say a 0.5mg dose, than if I had it in pill form. Is this correct ?

Also, what's the deal with sublingual bioavailability ? I would think the fact that it comes in a sublingual film form means it has a relatively decent BA via that ROA, but the FAQ quotes some conflicting statements. What is it really ? 30%? 50%? 90%?

I just want to know because I plan on taking 0.5mg sublingually since it's already in film form. I know I should be perfectly fine at that dose regardless, but would like to know what I'm truly getting dose wise.
 
^ the BA is around 30% and can be raised a little bit if you use alcohol sublingually with the film.

Yes it is easy to cut the strip into pieces; you are essentially eyeballing it though. I prefer liquid measuring, which is very accurate and reliable.
 
Sorry for asking a question that's undoubtedly been asked before, but after searching the OP for possibly related topics and this whole thread, I couldn't find what I was looking for, so I decided to go ahead and ask. And anyway, maybe this should be in ADD but well... here it goes.

When taking Suboxone sublingually (as recommended), why does naloxone not replace (or at least partially) buprenorphine at mu-opioid receptors given its high affinity? If this is because bupe has even higher affinity than naloxone, what is the reason that taking other opiates won't work? Because buprenorphine is already occupying your receptors or does naloxone do something as well?

Is naloxone really only added to the mixture to prevent people shooting Suboxone? So, when shooting up suboxone, I take it that naloxone does bind to your receptors more quickly than buprenorphine when iv-ing, so that might explain one part of my question (if I'm right)... But does buprenorphine then still occupy your opioid receptors?

I hope these questions make sense, they've been bugging me for some time now. Cheers BL! :)

[edit] I think I might have found most of the answers indeed, but do still wonder if adding naloxone was only done for patent reasons and not to prevent users from shoothing up other opioids.
 
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Snapinho said:
Sorry for asking a question that's undoubtedly been asked before, but after searching the OP for possibly related topics and this whole thread, I couldn't find what I was looking for, so I decided to go ahead and ask. And anyway, maybe this should be in ADD but well... here it goes.

When taking Suboxone sublingually (as recommended), why does naloxone not replace (or at least partially) buprenorphine at mu-opioid receptors given its high affinity? If this is because bupe has even higher affinity than naloxone, what is the reason that taking other opiates won't work? Because buprenorphine is already occupying your receptors or does naloxone do something as well?

Is naloxone really only added to the mixture to prevent people shooting Suboxone? So, when shooting up suboxone, I take it that naloxone does bind to your receptors more quickly than buprenorphine when iv-ing, so that might explain one part of my question (if I'm right)... But does buprenorphine then still occupy your opioid receptors?

I hope these questions make sense, they've been bugging me for some time now. Cheers BL! :)

[edit] I think I might have found most of the answers indeed, but do still wonder if adding naloxone was only done for patent reasons and not to prevent users from shoothing up other opioids.
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The naloxone was added to suboxone as a scare tactic. It doesn't do shit. Bupe has a higher affinity than naloxone no matter how it is ingested, sublingual, IV, doesn't matter.

The reason taking other opiate wont work is the same.. because bupe has a higher affinity and doesn't allow any other opiates to attach to your receptors.
 
Cliron said:
http://www.businesswire.com/news/ho...icals-Receives-FDA-Approval-Generic-Suboxone®

Pretty fecking exciting stuff. The FDA struck down that farce of a citizen's petition R&B proposed. Generic suboxone by early March. Niiiiiiiice.
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Yeah there's a thread about this in DitM.

Very exciting times. :)

Unfortunately, even if there's generic Subutex/suboxone, R&B has such a monopoly that it has doctors convinced that brand name Suboxone is the only product they should prescribe. I don't know if they so much convince the doctors or give them under the table bonuses for prescribing it over a generic, but it's definitely something. I know people who pay way too much for a monthly prescription because they can't get their doctor to prescribe a generic.
 
Captain.Heroin said:
^ the BA is around 30% and can be raised a little bit if you use alcohol sublingually with the film.

Yes it is easy to cut the strip into pieces; you are essentially eyeballing it though. I prefer liquid measuring, which is very accurate and reliable.
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Ok, thanks for the info. I'll still attempt to just cut the film, I'll be fine as long as its 1mg or less.
 
Thanks Scagnattie. I had no idea and I know for sure that most opiate users round my neck o' the woods don't either. The only reason they take bupe in the form of Suboxone is that the only alternative is Temgesic and nobody wants to have a mouthful of pills dissolving on a daily basis. Interesting to know, too.

By the way, regarding naloxone being added as a scare tactic, does anyone know of scientific articles that back it up? It'd be interesting to show to some people I know that work for R&B and are in the bupe business. Good people too, and intelligent, so I wonder how much they know about this scheme...
 
Reverend Random said:
By the way, regarding naloxone being added as a scare tactic, does anyone know of scientific articles that back it up? It'd be interesting to show to some people I know that work for R&B and are in the bupe business. Good people too, and intelligent, so I wonder how much they know about this scheme...
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You can find out the affinity for buprenorphine versus naloxone for the mu-opioid receptor.

Furthermore, I witnessed someone IV naloxone while already on buprenorphine, and they didn't experience anything negative.

I have also used micron filtered solutions of Subutex and Suboxone, at equal dosages, and got identical effects.
 
Doesn't using a benzo counter the effect of the naloxone as well? Similar to how people mix it with alcohol or methadone.

Interestingly even though its a scare tactic, it has lowered the IV considerably. Michelle Lofwall gave a very good webinar on diversion of buprenorphine where she had alot of stats to back it up especially on a global level.

http://psychiatry.org/practice/prof...ersion-and-misuse-from-office-based-treatment
 
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