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Bupe Suboxone/Buprenorphine FAQ & Megathread v3; 2010 - 2022

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This is truly not something I'm interested in doing myself. I just have been running into a few people in my town that swear by it. The reason I asked is purely for educational purposes only. I was baffled that people were doing it, but thought maybe they know something I don't. Honestly it scares me to think...... The burn...... Must feel like being maced.
It did peak my interest though. One guy was actually nodding out from a small piece put into his eye. He said he has been on suboxone for a few years and it's the only way he feels anything from them.
I am interested if anyone has experience with it out even heard of people doing it that way.
 
There is no way that putting it in your eyes is more effective than IV or IM since the IV BA is 100%. I doubt that intra-augen administration (I made that term up, but I kinda like the sound of it) would he any higher BA than intranasal administration, but you're not going to find any studies on this. For a drug that's prescribed to treat addiction, people sure go a long way to abuse it.
 
i are spectre said:
http://www.ncbi.nlm.nih.gov/pubmed/21857500

has anyone heard of that? i definitely notice it now that i think back.
Click to expand...

That's very interesting to me because I've had sleep problems ever since switching from MMT to BMT. I plan to bring it to my MD's attention. I'm already on K-Pins but would gladly give them up if this drug, eszopiclone works. Thanks for the info. I wonder if there is further research that supports this???
 
yes i am curious as how this compares with other opiates. some more info would be great.

not getting enough sleep has consequences and id imagine after YEARS it could do some real damage.

edit: methods to reduce this problem? besides benzos. exercise and diet i suppose, any other non-addictive supplements? kava and valerian i suppose, but those can taste pretty gross and also wear off eventually.
 
i are spectre said:
edit: methods to reduce this problem? besides benzos. exercise and diet i suppose, any other non-addictive supplements? kava and valerian i suppose, but those can taste pretty gross and also wear off eventually.
Click to expand...

My guess, is that an ORL-1 antagonist could help. I'm not sure if ORL-1 antagonists would have a greater affinity than buprenorphine for the ORL-1 receptor or not though.

It also seems that opiate tolerance may be connected to the ORL-1 receptor as well...

from http://en.wikipedia.org/wiki/J-113,397...

J-113,397 is an opioid analgesic drug which was the first compound found to be a highly selective antagonist for the nociceptin receptor, also known as the ORL-1 receptor.[1][2] It is several hundred times selective for the ORL-1 receptor over other opioid receptors,[3][4] and its effects in animals include preventing the development of tolerance to morphine[5], the prevention of hyperalgesia induced by intracerebroventricular administration of nociceptin (orphanin FQ),[6] as well as the stimulation of dopamine release in the striatum,[7] which increases the rewarding effects of cocaine,[8] but may have clinical application in the treatment of Parkinson's disease.[9][10][11]
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hyperalgesia is an increased sensitivity to pain.

I also thought this would be of interest....

from http://en.wikipedia.org/wiki/Ro64-6198...

Ro64-6198 is an nociceptoid drug used in scientific research. It acts as a potent and selective agonist for the nociceptin receptor, also known as the ORL-1 (opiate receptor like-1) receptor, with over 100x selectivity over other opioid receptors.[1] It produces anxiolytic effects in animal studies equivalent to those of benzodiazepine drugs,[2] but has no anticonvulsant effects and does not produce any overt effects on behaviour.[3] However it does impair short-term memory,[4] and counteracts stress-induced anorexia.[5][6] It also has antitussive effects,[7] and reduces the rewarding and analgesic effects of morphine, although it did not prevent the development of dependence.[8][9][10] It has been shown to reduce alcohol self-administration in animals and suppressed relapses in animal models of alcoholism, and ORL-1 agonists may have application in the treatment of alcoholism.[11]
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This is likely connected to why people have to wait after having taken buprenorphine to use full agonist opiates; even in cases where a small-ish dosage of buprenorphine was consumed. This is very interesting.
 
7 days without!!! Wasnt nice but wasnt too bad either.
Had 1mg half hour ago. Starting to feel gooood :)
Good saturday to everyone!
Im gonna head outside since the weather iss niice..
 
I don't believe applying sub to cuts anywhere or the membranes would increase the BA. I give my whole mouth a good brush before taking sub to remove the mucus barrier but to actually damage it would cause swelling and other local reactions that would actually reduce BA.

I don't think taking it through either your eye nor your navel would work either. Best is IV followed by membranes in nose or under tongue.

I leave it there for 20 minutes to maximize absorption this requires controlling your saliva and swallowing.
 
I know you're not straight up encouraging IV drug use, (just referring to it's superior BA), but let's refrain from saying IV is the best. First of all, I don't agree with that, and second of all, despite it's 100% absorption, IV has drawbacks as well. The duration is much shorter (say good bye to 1-2x/day dosing), there is no rush, without being properly micron filtered, the cuts within suboxone pills can be pretty gnarly n your veins.

If you don't like sublingual, I would go for rectal dosing, as it has an onset almost as quick as IV, and it doesn't involve sticking needles in your arm.

BA:
IV-100%-duration IME is about two hours
Rectal-54%- I find the duration to be as long as sublingual, with a cleaner feel.
Insufflation-50%-lasts almost as long as sublingual, pretty much the same as rectal.
Sublingual-30%-duration depends on dose, but I find it holds me the longest. The onset is slow, and effects peak around 1 hour and 30 minutes. For some reason I find sublingual gives a more "full agonist" feel when taken at low dosages, though thats just my personal experience. By using an alcoholic solution with your sublingual suboxone, you can raise your absorption as high as 70% I believe too.
 
Intranasal sub strips help

Ok, I don't know if there is a forum for this kind of question elsewhere since I notice the anality of everyone when it comes to thread placement. Anyway, I'm having a hell of a hard time getting good absorption out of my suboxone strips intranasally. I've tried two methods and both leave me feeling like I wasted a lot. I liked the pills a lot better for this cause you just crush and snort and absorb most of it. The first method I tried is dissolving in water and snorting. The problem here is getting the liquid to STAY in your sinus. So much seems to run back down my throat that I waste tons and I can tell by the subjective effects that I lost a lot. The second thing I tried is rolling the strip up, grabbing it with some tweezers, ind inserting it way up my nose into my sinus. I've had mixed results from this. Sometimes it'll start burning about 20 mins in and I know I'm getting a good dissolve up there and I feel it good, at other times my nose is too dry or something and I never get the burn and it's almost like it dissapears with no effect. So here's what I plan on trying next, I'm going to dissolve the strip in a little water, then take two q-tip ends and ball them up like you do when you filter a shot, drop them in the solution and let it all absorb into cotton, then shove the cotton tips up my nose. I'm the dedicated type! Or just crazy. So what do you think? Anyone else with this problem or have ideas?
 
i suggest you just accept the fact they are film and take it as directed, its not like it's some euphoric drug that will have u in opiate heaven, its a partional agonist, u may feel a buzz 2 or 3 times and thats it..if ur trying to put it up ur nose for higher BA, well dont bother supposedly these films have a higher BA sublingually than the tablets..why waste time and energy figuring out how to put a film up ur nose or try to dilute it in water or whatever, at the best i can reccommend just shoving the film up ur ass as you will reach a BA of close to 100%, and uw ill experience better "effects" if any that bupe gives from person to person...give it a rest
 
ultrams, suboxone, and hydrocodone

im coming off about a 1mg maintenance dose of subs and i have ultram and some hydro's 10's. its been 24 hrs since my last dose of bupe and im starting to feel pretty bad. 1st question is will the ultram help with w/d and second question is when can i take the hydro's and catch a pretty good buzz. also if i like take half a lortab 10 while im in bad w/d will it ease them or make them stop. and i know it will cause tolerance to the lortabs again. but whats a junkie gonna do. its pitiful. i cant afford to take bupe forever and its sad the doctor bill and meds are so high in the states.
 
Lol justification for not continuing with suboxone and relapsing: $

Too funny man, too funny. Just proof our brains CONSTANTLY rewrite this shit (see some of my earlier posts). Tell me now, what was the ORIGINAL REASON you quit using, $? I'd wager it was something entirely separate than $. Maybe sit and be honest with yourself about why you quit in the first place.

How much did your opiate addiction run you?

Consider staying on the bupe longer amigo. Clearly aren't ready to get off of it lol.

Having said all that, if you must know you wont feel dick from those hydros, for at least 48 hours i'd say after bupe. And even then, probably not much. Bupe is WAY STRONGER than hydro. Like, by several magnitudes. You possibly wont ever be able to get high from hydrocodone again, if you were on a high enough maintenance dose of bupe. I know you said 1mg but idk if you were at that dose your entire time (if you were at like 8 for 6 months prob kiss vicodin goodbye). Bupe fucks your tolerance permanently.
 
IV suboxone

okay so im wondering if i can IV my suboxone safely and if the naloxone has any effects. if so how. i only want experienced educated answers for my own safety... thanks a lot for your time and knowledge guys.
 
you can IV subs, I wouldnt say safely, the nalaxone doesnt do shit imo as buprenorphine has higher affinity for receptors than other opiates or nalaxone. most of all, you will get NO rush from banging subs. I wish you could, or I could rather lol, but you cannot get a rush from injecting subs.

did I mention that you get no rush from banging subs? Im a long time IV user, done lots of different opiates, my fiance too, and neither of us, as much as we both have hardcore addictions and needle fixations, will bang subs. When we get them we eat them, well, let them dissolve under our tongues, tho the taste gags her much more than it does me. I dont even snort em.

It is also both of our opinions that you cannot "stretch" a sub by banging it.
 
Just a week ago I tried Iv them and I continued to iv them for few days .I started off with 2-3 mg pieces of the strip and then lowered to 1mg few days later.You feel them way more when You Iv 1mg iv is like 8mg under tongue and I even kinda feel a little high especially if you smoke some exotic bud after .When you iv the sub it takes 10 mins to kick in I done it like 5 times and niver went into precipated withdrawl.I use like 50 60 ml water and filter with cotton 1-3 times depending on size of sub peice im using.Be careful I read you can lose a arm if you miss
 
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