"I am NOT an expect in these fields, however I do know much about the topic. Those of you who do know much more, feel free to correct anything that seems to be misleading or misinforming"
I was sharing information, some of which I had heard from doctors, others through my own research, and some based on my own experiences. doesn't mean that the doctor was correct.
The way I understood it is that naloxone has poor bioavailability sublingually, so you mainly get bup. however injecting, you bypass that and inject the naloxone in full as well....
I believe you that it is possible if you have done it... just hard to imagine because I know so many people that are on suboxone that have tried to abuse it all the time...
Also, isn't it the bup, not the naloxone, that causes precipitated withdrawl? The previous opiate and the buprenorphine in a sense 'fighting' over receptor sites. This is what I understand from the suboxone literature...
I guess my question is... if it DOESN'T prevent injecting, then what IS the naloxone useful for in the formulation of suboxone?
Good Question, the answer is not much, or not anything in Western literature promoting suboxone for sure. Suboxone is a pain reliever with analgesic effects 25 to 40 times as strong as morphine. It has been used in every other country in the world for severe cancer & neurological pain. It has been used for over 10 years in Europe, and bupe is even used for post op pain (PCA) which brings up the question of the ceiling effect, why use it as pain pump every 10 min when it won't work over 32 mg? Perhaps the ceiling effect is actually for respiratory depression and not pain? I don't know.
What I do know is that the US introduced bupe as a opiate blocker because it had only methadone (which isn't a opiate blocker) to compete with in that market. Why introduce another pain pill into an already billion dollar industry. Purdue made 1.2 billion on oxy alone in 2007. The literature on bupe is highly misleading (and not true), it CAN be injected because the bupe has a MUCH higher affinity for the receptors than the naloxone, snorting it will not cause precipitated withdrawals either, the information says that because it was marketed as a way to get off of opiates, simply, they lied, and they are hardly the first to do so!
Naloxone does not block the effects of other opiates, bupe binds itself more strongly to the receptor sites in the brain than do other opioids, making it harder to become intoxicated by other opioids when bupe is in the system, regardless of the presence of naloxone.
It seems to me that in the preparation of suboxone, naloxone is useless.
FYI Bupe is widely abused in some countries, by crushing and IVing the pill. In a test former addicts who hadn't used in 1 year were given shots intramuscularly of placebo, morphine, bupe, and other opiates. The subjects who received bupe identified the drug they were given as heroin.
Hepatic necrosis and hepatitis with jaundice have been reported with the use of bupe, especially after IV injection of crushed tablets.
