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Bupe Suboxone/Buprenorphine FAQ and Megathread v.1; 2007 - 2010

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ok well i iv'd 4mg and i can say i definitely felt it. the only reason i did it is cause there was no talc in it (which is the most important reason pills are bad to iv). it was pretty nice honestly. i haven't done opiates in a few days too so i guess my tolerance was low, but i definitely have a nice long lasting opiate high. only a couple complications... first is the injection site became swollen. i thought i missed the shot but it didn't bubble or anything and someone experienced said it wasn't a missed shot. its several hours later and its still pretty swollen. can anyone say anything about this? and something else : at some point i was no longer able to swallow solids. i had no problem with liquids, but when i swallowed food, it would just stay at the top of my throat. can anyone say anything about this? cause this worried me a lot..... has this happened to anyone else?
 
ok i wanna bump this and add that the bupe also has a higher affinity so i figured the nalexone wouldn't do anything. there wasn't a rush tho... it came on pretty slow. but its likes +9 hours and im still feeling as good as the second i came up
 
johanneschimpo said:
I do too. I'd love to keep it that way. Perhaps you should do some fact checking in some of your posts. Other than that, welcome to BL.

"I am NOT an expect in these fields, however I do know much about the topic. Those of you who do know much more, feel free to correct anything that seems to be misleading or misinforming"

I was sharing information, some of which I had heard from doctors, others through my own research, and some based on my own experiences. doesn't mean that the doctor was correct.

The way I understood it is that naloxone has poor bioavailability sublingually, so you mainly get bup. however injecting, you bypass that and inject the naloxone in full as well....
I believe you that it is possible if you have done it... just hard to imagine because I know so many people that are on suboxone that have tried to abuse it all the time...
Also, isn't it the bup, not the naloxone, that causes precipitated withdrawl? The previous opiate and the buprenorphine in a sense 'fighting' over receptor sites. This is what I understand from the suboxone literature...
I guess my question is... if it DOESN'T prevent injecting, then what IS the naloxone useful for in the formulation of suboxone?
 
Also, isn't it the bup, not the naloxone, that causes precipitated withdrawl? The previous opiate and the buprenorphine in a sense 'fighting' over receptor sites. This is what I understand from the suboxone literature...

The bupe plain kicks the other opioids off the receptor, it has a much higher affinity. The naltrexone may be why IV sub takes a while to come on, I don't know.
 
triiper said:
at some point i was no longer able to swallow solids. i had no problem with liquids, but when i swallowed food, it would just stay at the top of my throat. can anyone say anything about this? cause this worried me a lot..... has this happened to anyone else?

has this ever happened to anyone? its a lot better now, but seriously, what the fuck was that?
 
psychotic said:
"I am NOT an expect in these fields, however I do know much about the topic. Those of you who do know much more, feel free to correct anything that seems to be misleading or misinforming"

I was sharing information, some of which I had heard from doctors, others through my own research, and some based on my own experiences. doesn't mean that the doctor was correct.

The way I understood it is that naloxone has poor bioavailability sublingually, so you mainly get bup. however injecting, you bypass that and inject the naloxone in full as well....
I believe you that it is possible if you have done it... just hard to imagine because I know so many people that are on suboxone that have tried to abuse it all the time...
Also, isn't it the bup, not the naloxone, that causes precipitated withdrawl? The previous opiate and the buprenorphine in a sense 'fighting' over receptor sites. This is what I understand from the suboxone literature...
I guess my question is... if it DOESN'T prevent injecting, then what IS the naloxone useful for in the formulation of suboxone?


if a non-opiate tolerant person shoots suboxone, they will get a "high" from the buprenorphine itself. if a opiate tolerant person shoots suboxone while another opiate is "active" in their system, they will go into precipitated w/d. if they wait long enough for the previous opiate to leave the receptors, they will be fine.
and you were right about naloxone having a much better bioavailability when injected but the bupe still wins everytime.
and yes, the bupe is what causes the precipitated w/d
basically, i don't think there is much the naloxone is useful for in suboxone. i think the ppl who made it put it in there to "scare" ppl away from abusing it but i'm not sure if they knew the bupe was actually gonna overpower the naloxone anyways. mostly just a scare tactic. just like now, i read that companies that make oxycodone are thinking of making an "abuse resistant" form of oxycontin with naloxone in it. in this case, i believe the naloxone would win. not 100% sure tho.
 
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this stuff is good to get high on, no doubt. shot 4mg again today and its like +12 hours and im still high. euphoria ain't as much as oc obviously, but theres still some, and the length more than compensates. don't think it would happen without all the weed, but w/e
 
triiper said:
this stuff is good to get high on, no doubt. shot 4mg again today and its like +12 hours and im still high. euphoria ain't as much as oc obviously, but theres still some, and the length more than compensates. don't think it would happen without all the weed, but w/e


You can smoke weed on that shit? *puke*
 
triiper said:
ok well i iv'd 4mg and i can say i definitely felt it. the only reason i did it is cause there was no talc in it (which is the most important reason pills are bad to iv). it was pretty nice honestly. i haven't done opiates in a few days too so i guess my tolerance was low, but i definitely have a nice long lasting opiate high. only a couple complications... first is the injection site became swollen. i thought i missed the shot but it didn't bubble or anything and someone experienced said it wasn't a missed shot. its several hours later and its still pretty swollen. can anyone say anything about this? and something else : at some point i was no longer able to swallow solids. i had no problem with liquids, but when i swallowed food, it would just stay at the top of my throat. can anyone say anything about this? cause this worried me a lot..... has this happened to anyone else?

just because it doesnt have talc does not mean its safer. In fact, suboxone is probably the worst possible pill you could choose to shoot because jsut about everything in it is water soluble, meaning all of it ends up in your veins.
 
sixpartseven said:
^ I disagree. For me, it mixes perfectly with both.

Das why I said "personally" I know it works well with some people but just makes me feel icky.
 
sixpartseven said:
just because it doesnt have talc does not mean its safer. In fact, suboxone is probably the worst possible pill you could choose to shoot because jsut about everything in it is water soluble, meaning all of it ends up in your veins.

yeah exactly. its the insoluble things that cause problems, no?
 
^ I may be wrong, but I think it may be the case that a fair amount of the binders and fillers are just 'particles in solution'... if that's the right term. Not dissolved, but floating around waiting to cause damage.
 
yea that's how the talc gets through filters and fucks up your lungs. i know cellulose and a few others act this way as well, but i never found extremely severe complications with substances other than with talc. i didn't look very hard though i'll admit

edit: the particles in solution are insoluble, as you know
 
edit: the particles in solution are insoluble, as you know

Yeah, sometimes people use the terms interchangeably (particles suspended in solution/dissolved) even though technically it's not correct.

Someone else can probably expand on the problems sub can cause when IV'd, it's something I don't know too much about.
 
triiper said:
yeah exactly. its the insoluble things that cause problems, no?

Its both. Things that are soluble and get in solution and in to your veins are terrible for you (flavoring, coloring, soluble fillers/binders) and then anything that is insoluble is bad for you as well.

Some assume that Suboxone/Subutex is safe to shoot because it completely dissolves. This is not true at all. In fact, it makes it more dangerous because the things that do the damage to your body from the inside are getting into solution much easier than they are with other pills because of their solubility.
 
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