Strangest drugs.

[BadBoy377]

The tropane containing plants are not for beginners. But they have their place.

Was gonna say @negrogesic , if you like that kinda vibe maybe give datura or nightshade a blast. Smoking best but also an alcohol extract added to cigarettes is supposed to be interesting. I'm never saying never again but I kinda like my y brain in reasonable working order.

 

[DeathIndustrial88]

DXM is such a weird drug. An opioid (by structure) for coughing (traditionally treated by mu agonists), with no mu opioid activity (in the d isomer at least). It's got contradictions baked into it.

In terms of its pharmacology, it hits the mysterious sigma 1 receptor, which seems to pop up in some of the most popular drugs of abuse (it helps tune calcium release that is subsequent to other receptor activation), and I think it's understudied. Weird receptor as well, lacking homology to other common receptor types (like ion channels, gpcrs, and steroid receptors).

If it weren't for its SNRI effects I'd rank it up with ketamine (or better as it's orally active). I get a weird nausea/stomach unrest with drugs that raise serotonin (even cocaine is more unsettling than other stimulants) and I feel like rolling is a coin flip to whether I puke.

Totally agree.
I'd still be utilizing DXM if it wasn't for the nausea & serotonin side effects. It ends up making it a dirty drug, but still a weird one nonetheless.


I think some guy named William White (maybe) wrote a whole thesis on DXM use & he also mentioned paranormal & strange things happening to people on DXM. And I've seen it first hand on some of my own trips with it. I think you can find what he wrote about it on Erowid still.



Aaah, here it is - https://www.erowid.org/chemicals/dxm/faq/dxm_paranormal.shtml#toc.8
It's a very interesting read.

And here's the full guide - https://www.erowid.org/chemicals/dxm/faq/

 

[DeathIndustrial88]

This. Some extremely weird stuff happened with me for Haldol, but DXM has been the strongest and strangest trips to date.

You might find this interesting to read if you've ever had mystical or paranormal experiences on DXM.

Erowid DXM Vault : DXM FAQ - Altered States

DXM FAQ : Altered States, by William White

www.erowid.org

I found using high doses of DXM caused a lot of synchronicities, coincidences & oddities to start happening around me. And they were visible/experienced by people around me who were sober or not on DXM at all.


Never seen any aliens or beings on DXM, but apparently it's not uncommon either.


I actually miss these experiences. I use to go for DXM trips, put on a pot of coffee & just go into my own world for hours & hours. Like being in a trance-like state. My mom would laugh at me doing the robo walk n shit. lol But I think I've long passed my 50 trip limit with DXM. And now that I'm in my mid-to late 30's, I worry about the side effects. It was eaiser to deal with nausea, puking or what ever other side effects in my 20's, but I'm afraid by going on a big dose of DXM now a days that I could end up doing some damage to myself or something. But DXM euphoria can be utterly profound in the higher doses. It's also scary as hell in some moments. But when I start to come down, it's like being reborn & feeling completely alive again, kinda similar to an LSD come down, but better in some aspects,


I remember one DXM trip where I was sitting at my computer with my headphones on & every time I closed my eyes, I would see myself at the top of these stairs. It was night time & looked like some kind of stairs attached to the outside of an apartment building or something. Nothing amazing or spectacular, but for some reason it was just so peaceful to close my eyes & stare down these mystery "stairs".

DXM is unpredictable IMO too. Like I could trip one week & have a total blast & then trip again the next week & the trip would be totally different & even freak me out or give me anxiety.

 

[deficiT]

All of these dxm recountings remind of shit I experienced on mxe or 3meopcp. Like I said, dissociatives are fucking weird. There was a period I was doing large amounts of 3hopcp & meth, IV. Talk about strange. But it was honestly awesome, stupid, but fun nevertheless.

Most stimulants are pretty normal at first, but they can definitely get very weird.

Meth and aphp probably two of the weirdest.

 

[DeathIndustrial88]

DXM is such a weird drug. An opioid (by structure) for coughing (traditionally treated by mu agonists), with no mu opioid activity (in the d isomer at least). It's got contradictions baked into it.

In terms of its pharmacology, it hits the mysterious sigma 1 receptor, which seems to pop up in some of the most popular drugs of abuse (it helps tune calcium release that is subsequent to other receptor activation), and I think it's understudied. Weird receptor as well, lacking homology to other common receptor types (like ion channels, gpcrs, and steroid receptors).

If it weren't for its SNRI effects I'd rank it up with ketamine (or better as it's orally active). I get a weird nausea/stomach unrest with drugs that raise serotonin (even cocaine is more unsettling than other stimulants) and I feel like rolling is a coin flip to whether I puke.

Also, I'm curious if you know how DXM asserts it antitussive action, if it doesn't actually activate the mu-receptor? I've always wondered about that.

I find it interesting too that naloxone is often used for DXM overdose. But how would it reverse DXM if DXM doesn't act on opioid receptors? So confusing.

 

[DeathIndustrial88]

All of these dxm recountings remind of shit I experienced on mxe or 3meopcp. Like I said, dissociatives are fucking weird. There was a period I was doing large amounts of 3hopcp & meth, IV. Talk about strange. But it was honestly awesome, stupid, but fun nevertheless.

Most stimulants are pretty normal at first, but they can definitely get very weird.

Meth and aphp probably two of the weirdest.

Dissociatives definitely win IME.

Deliriants are rather weird too, but they're not very enjoyable & are much more unhealthy & dangerous, I think.

 

[golego55]

You might find this interesting to read if you've ever had mystical or paranormal experiences on DXM.

Erowid DXM Vault : DXM FAQ - Altered States

DXM FAQ : Altered States, by William White

www.erowid.org

Thanks for the link.

DXM is unpredictable IMO too. Like I could trip one week & have a total blast & then trip again the next week & the trip would be totally different & even freak me out or give me anxiety.

This. In the past I've had some bad "cycle of doom/death" episodes, but the experience the other day was extremely positive and I'm not sure why that trip was positive compared to the previous negative ones.

I felt warmth/empathy towards others in my mind, had positive thoughts about negative life experiences, et al. I had super "sped up" thoughts, too. It was the most energized I've felt almost in my entire life, even though recently I've grown highly (and scarily) fatigued and depressed recently.

I should note, though, that I took lamotrigine too (a high dose), which often makes me feel emotional/clearheaded thoughts. In my natural state I have severe social anxiety, deep despair, and depression that prevents me from having good motor skills, being able to think in a productive way, et al. But man, that was the most positive and productive drug experience (and sober, too) I've ever had.

 

[DeathIndustrial88]

Thanks for the link.



This. In the past I've had some bad "cycle of doom/death" episodes, but the experience the other day was extremely positive and I'm not sure why that trip was positive compared to the previous negative ones.

I felt warmth/empathy towards others in my mind, had positive thoughts about negative life experiences, et al. I had super "sped up" thoughts, too. It was the most energized I've felt almost in my entire life, even though recently I've grown highly (and scarily) fatigued and depressed recently.

I should note, though, that I took lamotrigine too (a high dose), which often makes me feel emotional/clearheaded thoughts. In my natural state I have severe social anxiety, deep despair, and depression that prevents me from having good motor skills, being able to think in a productive way, et al. But man, that was the most positive and productive drug experience (and sober, too) I've ever had.

Man I've been feeling this lately as well.

I've been so fricking tired & lifeless lately. I feel so dead inside. Nothing seems to be enjoyable anymore.

I had 130mg of hydrocodone I got to play with last week & it barely did anything. Wasn't very enjoyable at all.
So I went back to my subs & usually my subs are at least slightly enjoyable, but even that's gone. Weed just makes me feel more tired & lazy.
And for awhile there, I was taking klonopin at night & it was giving me a very mild euphoric, relaxed "buzz" that was pretty enjoyable. Now that's gone too.

I just tried going for a walk and it felt so difficult. My whole body is achy & sore now.

I'm super tempted to do a big DXM trip to free my mind & body from this rut it's in. I've had those DXM trips where I become almost rejuvenated & suddenly have motivation & energy again & my body feels good. But I'm also worried about having a shitty/neutral trip instead.

I use to get trips that made me feel like I was dying too. I hated those, ,although when they were over, I still felt pretty alive & clear headed again.

This fatigue lately though is just so damn depressing. I want to feel alive again & enjoy things, but I dunno wtf to do. Maybe an extended break from all my daily meds/drugs, but that's easier said than done.

Glad you had a good trip though!

I've heard of lamotrigine, but have never tried it. That's weird that it seems to do the opposite of what it was intended for (aka, stabilizing your emotions & generally making one feel more tired or foggy-brained, rather than clear headed). Wonder if it would be helpful for me at all or if it'd just make my issues worse.

 

[Skorpio]

Also, I'm curious if you know how DXM asserts it antitussive action, if it doesn't actually activate the mu-receptor? I've always wondered about that.

I find it interesting too that naloxone is often used for DXM overdose. But how would it reverse DXM if DXM doesn't act on opioid receptors? So confusing.

I've heard it is due to the sigma 1 receptor agonism. Assisting that inference is that noscapine is sometimes used for cough, and its cited mechanism of action is through the sigma 1 receptor.

I'd be surprised if narcan did anything to dxm. Levomethorphan is a proper mu opioid agonist, but if dxm was a mu agonist, people would use it to stay out of withdrawal more, and there would be more deaths due to it.

Muscimol is pretty weird. Not too many orthosteric GABA agonists out there, and I've got no idea of why it causes hallucinations. Z-drugs are equally weird for that reason, but are allosteric modulators, like benzos, so less profoundly odd.

 

[DeathIndustrial88]

I've heard it is due to the sigma 1 receptor agonism. Assisting that inference is that noscapine is sometimes used for cough, and its cited mechanism of action is through the sigma 1 receptor.

I'd be surprised if narcan did anything to dxm. Levomethorphan is a proper mu opioid agonist, but if dxm was a mu agonist, people would use it to stay out of withdrawal more, and there would be more deaths due to it.

Muscimol is pretty weird. Not too many orthosteric GABA agonists out there, and I've got no idea of why it causes hallucinations. Z-drugs are equally weird for that reason, but are allosteric modulators, like benzos, so less profoundly odd.

Thanks for answering!

Yeah, in general I don't think DXM has an antidote, but I did read this -

Two Cases of Dextromethorphan Overdose Reversed by Naloxone

We present two rare cases highlighting the rare toxicological manifestation of dextromethorphan (DXM). The DXM toxicity profile is predominantly hallucinations, agitation, irritability with seizures, and coma in severe overdose. The cases that follow ...

www.ncbi.nlm.nih.gov

"Emphasis on a thorough physical examination and detailed history taking can reduce the time to definitive therapy and avoid morbidity, and in rare instances, mortality for the patients concerned, especially during emergency situations. We would like to advocate the advantage of using naloxone in reversing the DXM adverse effects if predominantly opioid in nature led to significantly faster recovery and reduced adverse events, early reversal, and early discharge home. Patients who abuse cough syrup require psychiatric counseling to help nip the inciting factor in the bud. Further research is required to institute the use of naloxone as an antidote for DXM toxicity."

Apparently I'm not the only one wondering though -



I wonder if naloxone antagonizes sigma receptors as well? If the sigma receptors cause the antitussive effect, then maybe overdose of DXM can suppress breathing similar to opioids in a way & naloxone would reverse this. But this is just me speculating as I haven't looked into it anymore yet, but it would make sense I guess.

 

[emkee_reinvented]

Still wondering about bromo-iso-valerianyl-ureum, what does it do?

bromisoval is a ring-opened barbituate type sedative

was in medication formula's from maybe the 50-ies.
.

 

[emkee_reinvented]

DXM is probably the strangest drug I've ever personally done. It's got dissociative/psychedelic properties & it's chemical structure is similar to that of an opioid (it's the d-isomer of levorphanol actually), though it doesn't really possess any opioid activity. In high enough doses it can cause out of body experiences, near-death-like experiences and I truly believe it even has some sort of paranormal or supernatural component to it (but that's a long story).

Some of my old DXM trips completely rivaled any mushroom or acid trips I've taken. But it's got a lot of physical side effects & I don't think I'd be able to handle it anymore at my age. It's not as visual as LSD or anything though. The trip is mostly an "internal" trip, if that makes sense. Although there are some hallucinations.

When I was 27, I went on a 900mg extended release DXM trip & smoked some weed at the peak. I suddenly felt like I was outside of my body & that I was watching my life play out as a movie that was about to end. I thought for sure I was going to die (thought I had accidentally taken too much or that an organ was shutting down). I basically laid on my couch next to my mom thinking I was done for & dying. But eventually I took a klonopin & started to come back to reality. The next day I was very much grateful that I was still alive.

What's strange to me is that something this powerful is available all over the store shelves, but I can't legally walk into a store & buy some opiates? Pfft.

Over here some people, the first sheep: mucisians, poets, artists. Used to Weed, Alcohol , Speed and the OTC cough surpressant.

Found LSD, which came after along with with Mescaline/ Mushrooms, kinda tame. Used to trippin on I assume DXM. How long has it been around that stuff? Its now illegal Interactions and recreative use. While it was an excellent cough supressant.

 

[DeathIndustrial88]

Over here some people, the first sheep: mucisians, poets, artists. Used to Weed, Alcohol , Speed and the OTC cough surpressant.

Found LSD, which came after along with with Mescaline/ Mushrooms, kinda tame. Used to trippin on I assume DXM. How long has it been around that stuff? Its now illegal Interactions and recreative use. While it was an excellent cough supressant.

DXM has been around since at least the 50's...

"A resolution of the two isomers of racemorphan with tartaric acid was published in 1952, and dextromethorphan was successfully tested in 1954 as part of US Navy and CIA-funded research on nonaddictive substitutes for codeine. Dextromethorphan was approved by the FDA in 1958 as an over-the-counter antitussive."

I don't think it really gained popularity as a recreational drug until the 70's & 80's though, starting with street punks & such.

 

[emkee_reinvented]

@DeathIndustrial88 a famous local artist, who spent a night partying with Jimmy Hendrix.
And looked like a brother/ look-a-like of him too, both big hair same bizar hippy clothing.

He described being underwhelmed by LSD, as he used to trip on a 'not by name/ substance' mentioned OTC cough supressant. That produced psychedelic states that went way deeper. So kinda prepared for a psychedelic experience on forhand. So it could have been DXM seeing the timing of release in the US.

This is when LSD or Mescaline were also still legal and just expended from use in universities and psychiatry, to the first group of mind explorers. Artists. He died not so long ago RIP 70 years old. Was a celebrity, reckognized poet and speed user.
'Mayor of the Night' in his city, an honour title he had some time.

 

[DeathIndustrial88]

@DeathIndustrial88 a famous local artist, who spent a night partying with Jimmy Hendrix.
And looked like a brother/ look-a-like of him too, both big hair same bizar hippy clothing.

He described being underwhelmed by LSD, as he used to trip on a 'not by name/ substance' mentioned OTC cough supressant. That produced psychedelic states that went way deeper. So kinda prepared for a psychedelic experience on forhand. So it could have been DXM seeing the timing of release in the US.

This is when LSD or Mescaline were also still legal and just expended from use in universities and psychiatry, to the first group of mind explorers. Artists. He died not so long ago RIP 70 years old. Was a celebrity, reckognized poet and speed user.
'Mayor of the Night' in his city, an honour title he had some time.

Didn't know all that! Interesting.

It very much could have been DXM that he was referring to.


I do personally find DXM more profound than LSD, but only in certain dosages. I think 1st & 2nd plateau trips are going to be underwhelming for an LSD user, but the higher plateaus are capable of producing some insane trips.


I actually like LSD too, but DXM has more of a 'mystical" and "alien" feel to it. LSD is colorful & makes you laugh & all that, but DXM is dark & strange in my experience. I wish I could still use it without worrying about all the crazy harsh side effects.

 

[emkee_reinvented]

Didn't know all that! Interesting.

It very much could have been DXM that he was referring to.


I do personally find DXM more profound than LSD, but only in certain dosages. I think 1st & 2nd plateau trips are going to be underwhelming for an LSD user, but the higher plateaus are capable of producing some insane trips.


I actually like LSD too, but DXM has more of a 'mystical" and "alien" feel to it. LSD is colorful & makes you laugh & all that, but DXM is dark & strange in my experience. I wish I could still use it without worrying about all the crazy harsh side effects.

Knowing the person mentioned he likely didnt go for the first plateau. Info must have been purely from here so transferred, wonder who all knew. If the doses he took were in the 3/ 4-th plateaus it would not amaze me.
It certainly was not Codeine he described or Noscapine.

Never knew DXM might have preceded LSD and Mescaline. Wonder if our inlandish Liberty Caps/ Psilocybine Semilanceata where known and also used before Acid came.

edit: DXM is btw illegal now/ no longer a medication.

 

[LucidSDreamr]

Gotta vote for DXM.

And other dissociatives in general. But DXM has something the other dissociatives all lack.

 

[BrdWithHats]

Mirtazapine is fucking bizarre at high doses. It’s an atypical antidepressant with a dose range of 15-45mg, but at doses of 100mg+ it becomes a pretty fun (albeit very sedating) delirious psychedelic. I was honestly shocked at how well it works, straight up LSD level of trippy

 

[daturetard]

Home made Salvia extract. Never been able to let my glaucium plants get big enough to get a good dose out of them but I've got a feeling that'll be pretty weird.

 

[TheFunkeeJunkee]

There's two different "classes" which I find more interesting then the rest. The first is the 5HT2a agonists that don't seem to produce a strong psychedelia but still, to some degree, maintain the therapeutic properties. 4C-D (Ariadne) comes to mind. I never had the opportunity to try it, but reports (and Alexander Shulgin) claim it was "special". Hell, even Bristol Laboratories considered it interesting enough to invest in some amount of clinical trials (it was never completed nor approved).

Irreversible agonists in general I find fascinating also, such as Oxymorphazone. These drugs form covalent bonds with their target receptors (hence being irreversible). In [1] radiolabeled Oxymorhazone, in vitro, "only" 70% bound at 5 nM so there's a spectrum to "irreversibility". Would the effects, duration and after effects of a drug such as Oxymorphazone be? No one really knows, sadly. The literature gives conflicting opinions on it's reversibility by Nalaxone with some suggesting it does reverse it's effects and others suggesting it doesn't. The duration would likely be long lived with pigeons showing analgesic activity for 48~ hours [2]. The duration would at most be limited to the lifetime of the occupied receptor. It's synthesis is simple enough, if you can get ahold of Oxymorphone.

[1] Varga E, Toth G, Benyhe S, Hosztafi S, Borsodi A. Synthesis and binding of 3H-oxymorphazone to rat brain membranes. Life Sci. 1987 Apr 20;40(16):1579-88. doi: 10.1016/0024-3205(87)90123-8. PMID: 2436019.
[2] France CP, Jacobson AE, Woods JH. Discriminative stimulus effects of reversible and irreversible opiate agonists: morphine, oxymorphazone and buprenorphine. J Pharmacol Exp Ther. 1984 Sep;230(3):652-7. PMID: 6206224.