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Stimulants of the Future

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I was dreaming about cathinone and methcathinone analogs : what about putting a methylene group on beta position of amphetamine nucleus ? The alkene is electron-rich and quite less polar than a carbonyl.

I'd also like know if the beta-methoxyamphetamine has been tested or synthethised ; shlugin talk about b-methoxy-phenethylamines in pihkal (BOx compound) and BOD seems to be a nice psychedelic.
 

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Beta-methoxyamphetamine is O-methylcathine (O-methylphenylpropanolamine) and beta-methoxy methamphetamine is O-methylephedrine. O-methylephedrine is like phenmetrazine with the ring cleaved between the ethylene bridge between the O and N atoms. Years ago it was on my to do list, but never got around to it. It looks very promising.

The beta-methyleneamphetamines (cathenine as Vanadium called it) is the basic structure I suggested would be possibly a more potent 5HT2a agonist when ring substituted than the corresponding amphetamines (see ;Acid, dragonflies & the 5HT2a receptor')
 
F&B do you by chance have any literature or have an opinion on C-Indan-1-yl-methylamine? (your opinion is always apreciated btw :) )

Can't find any info on it at all, wondering if it might be good. After seeing the SSRI/SNRI effects in the entactogens thread got a little too excited (slightly sad I know but there you go)
 
The fact that beta-keto amphetamine analogues suck (IMO) yet so many people continue to fantasize about their analogues suggests that they insidiously activate certain reward pathways, haha. ;)
 
Did anyone do/find any more info on 2-benzylpiperidine? It seems unreal that it wasn't investigated in the era when methylphenidate was developed. I would really appreciate any info on this substance. Please send me a PM if you for any reason do not wish to discuss it in the open.

Activity is, of course, of interest - but it's almost secondary to possible toxicity that differs from methylphenidate.
 
Jamshyd said:
The fact that beta-keto amphetamine analogues suck (IMO) yet so many people continue to fantasize about their analogues suggests that they insidiously activate certain reward pathways, haha. ;)
Click to expand...

The thought of a drug impacting on dopaminergic reward pathways is another tin of worms alltogether (psychological dependance on the thought of drugs - quite a few of us got that real bad!)
 
true story.

Years ago, I went to the science library to uncover the almost 100 year old German process of methylphenidate (Ritalin) manufacture, which is far from elegant.

Later, I decided to hybridize methamphetamine with methylphenidate, losing the cocaine benzyl methyl ester. The result, which I mentioned years ago at the hive but never made (although I have snorted it) is called 2-BzP.

No synthesis discussion

As far as toxicity, 2-BzP is less toxic than METH (no deamination catabolic reactions; ammonia and methylamine are toxic in vivo) but more so than Ritalin (methylphenidate)--mainly b/c 2-BzP lasts longer than methylphenidate b/c methyl esters are intrinsically easy to metabolize in short order by a living animal.

Note to world: I can't answer PMs yet.
 
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Thank you very much for the information. I love empirical data! :D Skip synth details though, or you'll probably get moderator-wrath.

So how was it qualitatively, and what dosages did you try?
 
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About a gram.
I had a nightmarish vision.
Other than that, it was similar to smooth but strong and long lasting meth trip.
 
^ Agreed. Who on earth, with the least knowledge of chemistry and pharmacology, would volontarily initially take one gram of a substance one is naive to? Especially considering structural likeness to methylphenidate. You're full of it until further explanation of this madness.
 
bydefinition said:
About a gram.
I had a nightmarish vision.
Other than that, it was similar to smooth but strong and long lasting meth trip.
Click to expand...

I assume you have met helios? I'm sure you two would really get along well :)
 
It was over a period of 3 days.
And it was crystal (or thereabouts).
And I don't know what the purity was.

Also, I would prefer it if you guys would refer to me as "chemically gifted" or "chemically psychic" or just plain "knowledgeable" rather than "schizophrenic" which I am most certainly not. Thanks.

PLUR.
 
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Just been reading about 3-phenyl-1-indanamide compounds, although not all the pages are on the google article which is annoying.

3-Phenyl-1-indanamines. Potential Antidepressant Activity and Potent Inhibition
of Dopamine, Norepinephrine, and Serotonin Uptake
Klaus P. Bergeser,*t A. Vibeke Christensen,t John Hytte1,t and Tommy Liljeforss
Departments of Medicinal Chemistry and of Pharmacology and Toxicology, H. Lundbeck AIS,

http://pubs.acs.org/cgi-bin/abstract.cgi/jmcmar/1985/28/i12/f-pdf/f_jm00150a012.pdf?sessid=6006l3

http://www.springerlink.com/content/p80t137101273264/

Pharmacology in vivo of the phenylindan derivative, lu 19-005, a new potent inhibitor of dopamine, noradrenaline and 5-hydroxytryptamine uptake in rat brain

Would be interested in 3-phenyl-2-indanamide, but can't find any references.
 

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Just realised the lu 19-005 compound is actually more similar to sertraline.

Still there might be a 3-phenyl-1-indanamide compound which is more in tune with dopamine type stimulants.

And still I am intrigued by the 3-phenyl-2-indanamide idea.
 

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Dude, the references are from '85 and are for setraline's twin brother indatraline.

The 3-phenyl-2-indanamide may or maynot be a good idea. Such novelties require literature based verification to prove their validity.
 
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