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Stimulants of the Future

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nocaine

it is interesting that nocaine which essentially lacks a lot of the locomotor activity of cocaine and is being investigated as a cocaine theraputic Cocadone al la methadone is the trans isomer of clarkes phenyl piperidine cocaine analogs (4-beta phenyl 3-alpha methoxycarbonyl), the cis isomer with the stereochemical configuration of the win series and cocaine is probably of more interest from a stimulant rather than anti cocaine point of view.
the cis trans mixture produced from arecoline via grignard at RT is also very ineffective as a locomotor stimulant in rats, suggesting that whilst the trans has reasonable DAT inhibitor activity it is not a good stimulant. the predominantly cis product produced at low temperatures is however an active stimulant and has been reported in some forensic literature.
 
Reminisant B said:
Does anyone know if other analogues of modafinil have been made and tested? (other than adrafinil + the pure isomer armodafinil)

I understand many new pharmaceuticals may target the same receptors but I don't mean the question in that sense.

I mean actual analogues of modafinil - like it could get interesting if something is substituted on the Nitrogen atom.
Click to expand...

the synthesis of 4 4' difluoro and dichloro have been reported, they are probably more active than the parent. I have not seen any test data, but I haven't looked for it.
nobody knows how modafanil works anyway so the SAR will be complex and probably unrelated to the DAT inhibtor SAR.
 
Actually I also thought the (S,S) or syn isomer of nocaine is pretty poor at behaving as a stimulant. It seems that by knocking out the tropane bridge of RTI-31 to get the corresponding piperidine compound/s you somehow whitewash the psychostimulant properties of the resultant inhibitors.

The paper dealing with the oxadiazole derivatized nocaine looks like an interesting read though.
 
vecktor said:
the synthesis of 4 4' difluoro and dichloro have been reported, they are probably more active than the parent. I have not seen any test data, but I haven't looked for it.
nobody knows how modafanil works anyway so the SAR will be complex and probably unrelated to the DAT inhibtor SAR.
Click to expand...

Hah, funny someone made those, I suspected they'd be they'd be one of the foremost attempted substituents in the series
 
vecktor: Isn't Modafinil a selective H3 agonist?

I too have tried Adrafinil (prodrug to Modafinil) on a few occasions - I really like it.

I'd describe it as a a cross between caffeine and methamphetamine, but with none of the "rushing energy" wired sort of feel. You just feel very, very awake, and very healthy and alert. None of the amphetamine "COME ON YOU SLOW BASTARDS!" feeling when dealing with people, there's little impatience etc.
You can go on long walks and such and well, you just don't feel tired.
And you can go to sleep on it!

I found it combined really well with traditional stimulants, as well as psychedelics & empathogens. Also, it's nice with downers such as opiates because you feel really really relaxed and nice but not sleepy...
 
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MattPsy said:
vecktor: Isn't Modafinil a selective H3 agonist?

I too have tried Adrafinil (prodrug to Modafinil) on a few occasions - I really like it.

I'd describe it as a a cross between caffeine and methamphetamine, but with none of the "rushing energy" wired sort of feel. You just feel very, very awake, and very healthy and alert. None of the amphetamine "COME ON YOU SLOW BASTARDS!" feeling when dealing with people, there's little impatience etc.
You can go on long walks and such and well, you just don't feel tired.
And you can go to sleep on it!

I found it combined really well with traditional stimulants, as well as psychedelics & empathogens. Also, it's nice with downers such as opiates because you feel really really relaxed and nice but not sleepy...
Click to expand...

indeed modafinil might be a selective h3 agonist, though some assays show no interaction with the human h3 receptor see link below. I have also seen it classified as an alpha 1 agonist, somehow something to do with GABA tone, a dat inhibitor, (it is a mild dat inhibitor) something to do with orexin etc etc. If the current theory is H3 agonism then I'll go with that.
either way in my experience modafinil is a very useful and productive substance, gets rid of the accumulated sleep deprivation.

there is a full free article on the wakefulness promoting activities of h3 antagonists here

http://www.nature.com/bjp/journal/v143/n5/full/0705964a.html
V
 
modafinil is as weak as water.
yes, vecktor we know you're smart.
you have nothing to prove wrt that here.
even PhreeX will tell you modafinil sux.
if you want a less "OMW IM TOO TWEAKED" than METH drug, try 3-MEO-METH.
It's stronger than either METH or MDMA, but not exactly like either.
More spun-proof but also more durastable.
A true astrodrug.
 
A ref. for that would be awesome, to prove this isnt another one of your philosophical speculations. I mean what people want is actual hard evidence (not just imaginary ideas).
 
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Since modafinil is almost insoluble in water, and it doesn't look like you can make some salt sol. either, I guess that makes it mostly uninjectable (unless something like DMSO or whatever works and is safe is used to dissolve it).
 
I work with DMSO on a daily basis, contact with just a minute amount ,will give you a horrible taste , all day long:p as far as injecting it , it also burns like hell8o (i wouldn't recommend it)
 
Rip-off

As you're a greenlighter you get a friendly hint instead of bringing down all sorts of shit

NO SOURCES FOR ANY REASON
 
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What did you expect with a name like the company you ordered from has? Generally, you want to steer clear of any business marketing tryptamines/phenethylamines as drugs. This is a pretty easy way to distinguish the scams, at least.

Usually all you get is an email txt file with what is available/prices, no fancy website or advertising.
 
Anyone else think this is going into too much information ;)

Nothing to do with sources please, its in the BL user agreement!
 
Yeah but it's pretty common kwowlege by now that site is bogus. So, he technically he didn't give source (yes he did & he will not do it again), he just added to what many already know. It's not source if said site is a wellknown ripoff scam (yes it is according to the BLUA). Since BL is about harm reduction, that post might help some people who don't know know.
Anyway, that's just my opinion
 
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back on topic

3-ethylmethamphetamine.
3-propylmethamphetamine.
3-isopropylmethamphetamine.
3-(n)-pentylmethamphetamine.
4-propylmethamphetamine.
4-(n)-pentylmethamphetamine.

Do Your Homework!!!
 
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