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Stimulants of the Future II

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This discussion is beyond the scope of bluelight at this point, but the methamphenidate thing looks good (if it had a methylamine instead of a hydrazine) as did some of the others.
 
Rectify said:
N-benzylmorpholine.hcl
(sorry couldn't resist)
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Considering drugs such as piracetam are being pumped out and sold in massive amounts, such a chemical as your suggestion genuinely could make a good nootropic agent.
 
^ What does piracetam have to do with n-benzylmorpholine???

Well, cyclobenzaprine is a tricyclic muscle relaxant, but that's miles away. I wouldn't be surprised if they had similar functions though.

stimulant too though. Indeed, quite odd. Don't seem to conform to any known pharmacophore.
 
nuke said:
Here is my submission, froganamine. I believe you will find the methylenedioxy ring as well as dual 2-phenylethylpyridine rings absolutely of the utmost functional quality for producing DA and NE release.

p.s. Please stop posting unsubstantiated crap.
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I'll try it.
 
Rectify said:
This discussion is beyond the scope of bluelight at this point, but the methamphenidate thing looks good (if it had a methylamine instead of a hydrazine) as did some of the others.
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Seriously, was that an accident? Why would that be suggested as such???

I don't think I've seen phenethylhydrazines, but benzylhydrazines are all MAOIs AFAIK, and irreversible.

Edit: Frogonamine appears to be entirely unknown :) You really should patent that! Have fun figuring out the IUPAC though.

Took me a while, and I'm positive I have something wrong, but 2,5-dibenzyl-7,10-diethyl-8,9-methylenedioxy-7,8,9,10-tetrahydrocyclohepta[ij][2,7]naphthyridine is as close as I'm going to get to correct.

It's right that methylenedioxy isn't used in IUPAC, correct?
 
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Right, but benzodioxole only applies when the methylenedioxy group is attached to a benzene ring, which is what confuses me.

Would I then call it 2,5-dibenzyl-7,10-diethyl-7,8,9,10-tetrahydrocyclohepta[ij][2,7]naphthyridine-8,9-dioxole?

You'd think, as pedantic as I am, nomenclature would interest me. It doesn't, but it feels a little like sudoku.
 
... 8)

V you weren't agreeing with me if that's what you thought.
 
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About the suggested structures by c0rt3x:

1. "Amphenidate": Not active IMO, due to beta-carboxy-moiety.
2. "Methylamphenidate": Probably toxic due to the hydrazine.
3. unstable due to acetalic moiety.
4.+5.: Both unstable due to ring-heteroatoms. A motif like N-CH(NH2)-O-CH(OMe)- won't stay put...

Quite pointless if one lacks some basic knowledge in a) organic chemistry and b) pharmacology. :\

- Murphy
 
I disagree on #1. it will almost certainly be active given methylphenidates activity.

methylphenidate is most often compared to cocaine with the ester, but methylphenidate is a secondary amine and cocaine a tertiary amine. I would be interested to know potent this would be with a primary amine.
 
I agree with Murphy.

Some of this stuff is more like adolescent doodling than intelligent design.
 
Well, intelligent design is a big fraud, but that seems unrelated...

but yeah, agreed except for #1 logic says should be active.
 
As far as I can tell, besides cocaine, none of these things are really coming from plants. Meth and amphetamine are entirely synthetic.
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Recently, the list of phenethylamines including Amphetamine and Methamphetamine has been removed from the wiki article about Acacia rigidula:

Chemical compounds found in Acacia rigidula
Acacia rigidula Bark
Acacia rigidula Seeds

* 3,4,5-Trihydroxy-phenethylamine (demethylated mescaline)[3]
* Methamphetamine
* Anhalamine[3]
* Beta-methyl-phenethylamine[3]
* Catechin[3]
* Dimethyltryptamine 323.8 ppm spring, 568.4 ppm fall[4]
* Fisetin[3]
* Hordenine[3]
* Mescaline[3]
* N-Methyltryptamine 4.6 ppm spring, 54.9 ppm fall[4]
* Nicotine[3]
* Nornicotine[3]
* Phenethylamine[3] 2314.6 spring, 5264.8 fall[4]
* Quercetin[3]
* Tyramine[3]
* Tryptamine 0.8 ppm spring, 21.2 ppm fall[4]

These findings have never been confirmed or discussed and are considered by some to be unlikely and a product of contamination or a hoax. Some of the apparently found phenylethylamines were previously only known as man made and their discovery would have been quite revolutionary. Also the authors of the 1998 study did not answer written requests.[5]
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c0rt3x said:
Recently, the list of phenethylamines including Amphetamine and Methamphetamine has been removed from the wiki article about Acacia rigidula:
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This research has never been replicated and the authors are not contactable.
so it goes into the bullshit category.
it is almost certainly lab contamination.
 
I thought dimethyltryptamine was a fairly well established component of acacias, no?

the collecting that they found makes me thing fraud though.
 
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