fastandbulbous
Bluelight Crew
the hydrazine relative of phenethylamine is actually a clinical MAOI antidepressant that's been used for years (can't remember name offhand)
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N&PD Moderators: Skorpio
Stimulants of the Future II
- Thread starter Hammilton
- Start date
- Status
phenelzine/ nardil
fastandbulbous
Bluelight Crew
^ Ever helpful (god I really think I'm starting to go a bit senile
)
dread
Bluelighter
Who knows what the future brings?
I would like to see a mostly serotonergic stimulant with slight NMDA antagonist effects. Something that would be kinda like MDMA, amphetamine and ketamine wrapped into one chemical.
Hammilton
Bluelighter
- Joined
- Sep 2, 2008
- Messages
- 3,435
That sort of exists already no?
Er maybe not. I am thinking perhaps 4-trifluoromethyl-lefetamine would be a possible one to try, or just plain 4-fluoro. They key is to maximise NMDA antagonism. Limiting opioid effects might as well be an afterthought, since I doubt it'll have any.
Edit: Actually does anyone know if 3-fluoro or other 3-halo analogues of morphinans are more potent? Or retain potency? I found one antagonist, but that's not very interesting. The 3-carbon morphine is equal to the 4-carbon on it's lefetamine analogues.
I love Chrome! it's kicking ie's ass as far as I'm concerned. youtube running a kanye video, chembiodraw and 3D gmail and a couple other smaller issues. I'm impressed, there's not a bit of slowing where usually at this point it was get kind of laggy.
Nagelfar
Bluelight Crew
Could a cocaine homologue be made with shorter half life (via being several magnitudes more metabolically liable, and since it is already very much so, is that even possible?) but with such a much greater DAT/SERT binding efficacy as to be a moment of absolute extreme bliss euphoria that wears right off in a minute, but due to duration displays very little oxidative stress & neurotoxicity? That would be my nice alternate answer to these long lasting stimulants..... It seems that under any constant 'altered' state your body & altered perception of pleasure in that state via receptors etc. seems to balance out and is no longer as extreme no matter how well it works.... it is the change, the moment of change, that rush that spikes the feeling, is what brings people back.
Hammilton
Bluelighter
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- Sep 2, 2008
- Messages
- 3,435
Agreed ^ It's what's so bad about phenethylamine. It's short acting and very euphoric. It is very much like cocaine in that sense. An amphetamine high compacted into 5 minutes is a bad idea. Fortunately it won't take off like mephedrone and some of the other RCs. People are scared of MAOIs, and rightfully. Many here couldn't handle the not killing themselves with a bratwurst or something equally silly, like not measuring your dose or crossing into MAO-A inhibition land.
And it doesn't even have to be a stimulant. Pretty much every shorter acting version of a psychoactive drug will be more euphoric and more addicting than the long lasting ones. Methadone vs. Fentanyl, secobarb vs. phenobarb, etc etc. I've said this so many times it's ridiculous!
What do you mean by homologue?
Nagelfar
Bluelight Crew
I mean same functional groups, maybe altered a bit but generally the same kind of ligand binding as cocaine, as it would seem to be the most likely starting substance for a purely re-uptake inhibition that I am trying to envision.
Well more addicting, more abuse liability, will always have a place, so it may have negative connotations, but does not all drugs of abuse? Well if it outdoes cocaine at it's own job, then it is 'of the future' in usurping it. Correct? :/
My other thoughts that are less tenable would be; a dopamine prodrug that de-esterizes (or what have you) in the proper places for dopaminergic activity and possibly actually working as an exogenous agonist, or any kind of dopaminergic agonist that is abusable.... or a drug where the catecholamine sythesis pathway from dopamine to norepinephrine is interrupted, maybe it binds to and destroys norepinephrine... the consequences to this are unforeseen, but I am thinking of alleviating the resulting jitterness of stimulant come down that is intrinsically associated with them all.
(edit: better yet! A chemical that turns norepinephrine back into dopamine and creates a feedback loop of dopamine just cycling around back into dopamine as it metabolizes in vivo while the chemical that does this persists in it's halflife: that is if I understand the catecholamine sythesis pathway, which I may not, it may not be the same as direct metabolism in that sense though I thought the body took one to make the other from one to the other.)Last edited:
LabRatNW
Bluelighter
Hammy... I know you are smarter than this!
They're reduced ephedrines. Ephedrines are most definitely plant based.
pofacedhoe
Bluelight Crew
http://users.lycaeum.org/~desoxy/Acaciarigidula.htm
amphetamines?
although these have been found in a plant synthetic production was how their use came into popularity and financial viability
ebola?
Bluelight Crew
How many drugs are synthesized using solely inorganic minerals as their precursors?
this report is dubious to say the least, a plant that produces nicotine and DMT and amphetamine yet no obvious biosynthetic intermediates or things like anabasine most strange.....MayDayMightyAttic
Greenlighter
- Joined
- May 22, 2008
- Messages
- 21
'b-keto-n-methyl-alpha-isopropyl-phenethylamine'
Is that what you get if you drink a mescaline extraction instead of evaporating the alcohol off?
god I'm funny
/navarone/
Bluelighter
Amphetam:
4-phenyl-5-methyl-pyrroli-2-one
MDPM
4,5-MethyleneDioxy-PhenMetrazine- Status
