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SSRI's and Ecstasy: The Final Word (Hopefully)

how much wellbutrin are you taking??
FYI, wellbutrin is a weak drug, it doesn't effect serotonin, and only minimally effects dopamine and norepinephrine...in fact Zoloft is a more potent dopamine reuptake inhibitor than wellbutrin
my advice: if the wellbutrin is only slightly working, try increasing to 350mg , if you have no increased responce to this, increase to 450mg...if no responce to this, add a SSRI, or just stop the wellbutrin and start a ssri....
was wellbutrin the first drug you have tried?...most pdocs start with the ssri's, then augment with welbutrin if there is only a partial response at max. dosage...
 
This is probably a stupid and over done question but is there any information on the long term effects of ssri's on the brain and serotonin levels?
I have done a search but came up with very little. A friend said he recently saw an article about the dangers of long term use of prozac but couldn't be more specific.
In addition, if there are long term dangers would this still be relevant for a single weekly dose of an ssri(ie to avoid neurotoxicity of mdma)?
 
Any comments on postlaoding with more than 40 mg of paxil??
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"these dazes are a trip; smile and keep on walking"
 
unless you are prescribed 40mg of paxil (meaning, you take it everyday) I wouldn't recommed it....40mg is a lot of paxil....10mg will do the job.
 
I'm still a bit unclear on the final word on postloading for non-depressed people attempting to prevent nerotoxicity. Are there any negative complications that are probable to arise from taking 10mg of something like Paxil 6 hours after the last roll?
 
this one is for NYTFLY.
After missing doses (1 day-several days-week-whenever) you go through a withdrawal (i.e. nauseau, "brain bounce"->electro-shock sensations in your head when you move suddenly, or vertigo->feeling like you don't have balance or are "falling up" or sideways.
I have never used any sort of SSRI's, but the electric shock sensation (from my head and all the way out to my finger tips and toes at some times) occurs 72hours after each time I roll...may that indicate a serotonin problem ? been trying to find an answer for this..without any luck, so really appreciate a reply
smile.gif
 
NYTFLY wrote:
Basically this means that even for MONTHS after one quits taking an SSRI, the brain is less efficient at using seratonin. Those who go off SSRI's and take E, even MONTHS later, will most likely have a REDUCED roll, regardless of the amount of E you take.
Click to expand...
So, What about ppl that post-load with SSRI's ?!?!? they will most have a reduced (next) roll too ? Or this is only for who takes as a med to depression, consequently by many days... ?
NYTFLY, can you give your opinion about SSRI post-load ? any negative side-effects ??
PS: PLUR NYTFLY
wink.gif

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PeaceLoveUnityRespect
 
GO Drug Dustbin GO!!
You rock man!! Run for Health Minister and I'll back you up to death.
Thanks for the info
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Diego Maradona. Y no hay nada más que hablar.
 
Woooowww!! NYTFLY and Drug dustbin.... are you somekind neurobiochemical specialists??? That was some pretty usefull information!! I got a friend who uses SSRI's and E. She's always complaining 'bout her roles. I already knew of the theory you published here. I just wished my friend could read English (she's Dutch). Maybe I should just translate all the informative stuff here and put up a Dutch MDMA users-site.
Thnx for the clear info.
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*I am feeling very weird*
 
I read your rating system for the SSRI's, but still have a question....
Anafranil ( Clomipramine )...where does this SSRI fit in to the rankings?
Thanks in advance
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Peace Love and Empathy,
The Bug Out Kid
"Do you wanna play with me?"
 
Ok stupid question here (im sure). But i was just diagnosed w/depression and put on Zoloft yesterday. My question is, besides MDMA, are there any other drugs that do not mix w/SSRI's? Can anyone clue me in?
 
thanks nytfly
me and one of my girls was wonderin if she should try it but im definitely gonna tell her to see her doctor if she wants to or if she wants to get off her meds. you are a life saver
holla
ben
 
WOW!! great post NYTFLY and responders...you know your shit!
i thought i'd just add a little anecdotal experience...
i was on 40mg/day of prozac (for the treatment of obsessive-compulsive disorder) for 2 months last spring. some observations:
1- i could not roll AT ALL, even when i took 450 mg of pure MDMA. so i believe that prozac always beats MDMA in the competition for the same receptors. I also could not roll for 5 months after going of prozac. i believe this is due to brain damage caused by prozac ( are there any studies on this?).
2- when i went off prozac, i went off with a 3 day taper and then cold turkey. that was a BAD idea! i was severely physically depressed ( lethargic, sleeping 16+hrs/day when i normally sleep 6-8 hrs/day) for a month. i can't imagine what being on paxil would be like if prozac is one of the least potent SSRIs!
3- i have been suffering from OCD since puberty ( i got diagnosed almost a year ago), but most severely since attending college ( i am now 20, a sophomore at stanford university). i got extremely good grades in high school, and though looking back i realize that i suffered many symptoms of OCD, i was more functional then than i am now ( with grades that are only mediocre/slightly above average). i now wonder whether my use of MDMA ( which i starting using about 6x/year the january of my senior year in high school) has increased the severity of my OCD because of fucking with my serotonin levels. i also wonder if my brief time with prozac has made it worse ( i am currently in my worst phase of OCD). what do others think about these hypotheses of mine?
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"I could not/Speak, and my eyes failed, I was neither/Living nor dead, and I knew nothing" - T.S. Eliot, The Wasteland
 
Are people that take SSRI's realy worsening they're anxiety/depression conditions?
At least for the weeks or months (after stopping medication) while thier seratonin reuptake returns to normal?
 
puss in boots:
quick answer - for many - Yes
tapering off the medication helps, also using a traditional benzodiazapine anti-depressant during the tapering/quitting of an ssri might help... although i am unaware of any study, etc... some of the more broad-stroke antidepressants have seratonergic properties among others ... like trazadone (an a-typical cyclic)... don't know about the various benzodiazapines (valium, zanax, ativan, klonapan, etc)
 
Well it took me three years to read that, but thank you for the useful info
smile.gif

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wisest is he who knows that he does not know...
 
This is off topic but I was curious as to what NYTFLY or Drug Dustbin take to preload or postload before they use MDMA, thats if they do use it. I know if you guys do use MDMA it must be on very rare occasions.
FatCat
 
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