I'm a little confused. A short while ago you (OctalBacchus115) posted a question regarding heavy use of NBOMe series compounds, specifically 25I, and spoke as if you yourself were consuming them. Now you post as if you are a mental health professional who is taking care of a patient who uses (abuses?) NBOMe series compounds. Which is it? Are you a health-care professional who is using your patient's forum account for fast access to Bluelight in order to query a large number of potential NBOMe users in order to build a picture of what this compound may be capable of vis-a-vis physiological/psychological damage? Or are you just using a more creative form of non-self-incrimination ('SWIMming')?
Either way, I'd like to help as much as I can, as I am sure the rest of the forum does as well. If you are just pretending to be a physician though, I would suggest that you just be straight and tell us, as we will probably be able to help you better without lies or half-truths.
Now then, I can tell you that I have consumed 25C-NBOMe probably 20-25 times without any lasting negative effect. I have experience with many other NBOMe series compounds as well, but 25C has proven to be my favourite so far. I have noticed lingering visual hallucinations for anywhere from 2 days to 2 weeks (depending on the dose) after consuming 25C, but I have noticed this with many of the other multitude of chemicals that I have consumed as well, so this is not anything particularly unusual or frightening for me. I have not encountered any other unusual or lasting effects, positive or negative whatsoever. This is not to say that it is impossible, as I have quite a lot of experience with psychedelics, both established and of the so-called "research chemical" variety, and have never experienced any lasting negative effects, so I may just not be predisposed to such things. Still, at least it's one point of data you can add to your survey.
Do you/'your patient' have any sort of history of mental illness other than the depression mentioned. Any family history of the same? How about any history of unusual or erratic behaviour? Have you/they experienced any unexplained mental symptoms such as auditory, visual, tactile, or olfactory hallucinations while not under the influence of any substances? How about paranoia? Any obsessive-compulsive behaviours such as unusual fixations with even or odd numbers, cleanliness, persistent unwanted unpleasant thoughts regarding violence (physical, sexual, etc) against yourself/themselves, loved ones, animals, or humanity in general? Have you/they ever watched TV, listened to the radio, read a book, or browsed the internet and become convinced that what they saw or heard was directed specifically at you/them, either to deliver a secret message or to mock/insult you/them? Have you/your patient found that you/they are sometimes unusually active and stimulated, with a seemingly endless supply of energy and a desire to spend money, have sexual intercourse, go long periods without sleeping, or do other such things that are out of the ordinary for you/them?
If you/they answered in the affirmative to any of these questions, it is possible that your/their psychedelic use has triggered or exacerbated a mental illness that had either not yet presented itself or had gone thus-far-undiagnosed. Your/their depression would/should have been a very good indicator that you/they should have been very cautious with your/their consumption of mind altering substances. Either way, the thing to do at this point is to cease all consumption of psychedelics and marijuana at the very least, and see if things improve. If I am addressing a physician, consider a full psychiatric evaluation, as there may be much more going on than the patient has been forthcoming about or is even aware of.
If I am speaking to the individual, please man, don't take any more NBOMe series compounds, or any other psychedelics for that matter, and definitely abstain from marijuana. I have heard of other people who have experienced such confusion after protracted use of psychedelics, and the damage has never been permanent in any of those cases. All that was required was that the individual take a break, and let their mind return to baseline. Maybe take this opportunity to look at things objectively and ask yourself why you are consuming psychedelics so heavily.
I hope this has been helpful, I wish I could offer more. If you/they have any more questions or concerns, I'm sure the whole forum will do whatever they can to help. I know I will.