atara
Bluelighter
Broadly speaking, side effects from psychedelics are kind of hard to predict and many may be psychosomatic. This is not to say they are strictly placebo, but that awareness or expectation of the side-effect substantially modifies it. A psychosomatic effect may be nonetheless very real and serious: the prototypical example is an asthma attack brought on by anxiety. Psychedelics can encourage delusive thinking (e.g. Terence McKenna, oh yes I said it), which exacerbates the potential for psychosomatic phenomena.
A remarkable feature of psychoneuroimmunology is that psychedelics can on occasion be able to modify the progression of autoimmune diseases, such as asthma:
http://www.erowid.org/experiences/exp.php?ID=15637
While very encouraging, the unpredictable nature of the psychedelic experience means that ordinary psychedelics are an unlikely treatment avenue. Psychosomatic effects can very easily take place in a negative direction and may include long-term anxiety, depression, and manic or fugue states. The propensity of individuals to develop such maladies may depend on preexisting mental factors, but these have not been characterized. Similar side-effects have been observed from meditative practices in which no drugs were used:
http://www.rickross.com/reference/brainwashing/brainwashing23.html
It is largely unclear what causes this. It is rather unlikely it is linked to any specific pattern of neurological changes. In particular, 5-ht2a agonists generally downregulate the 5-ht2a receptor, in common with agonists at other receptors. One would ordinarily expect this to coincide with sedation, a higher seizure threshold, lowered sociability, and a lower propensity for sensory distortion. My experience during periods of heavy psychedelic usage has been the precise opposite of all of this, with the exception of the seizure threshold (I have never had a seizure). That is to say that the long-term neurological effects of psychedelics do not in any simple way explain the long-term psychological effects.
One effect that is very real is priming, when a user expects an effect they are more likely to experience it, and so studies on drug users have, for example, shown that more drug-related impairment is measured if the subject is asked about his/her drug usage prior to completing an intelligence test as opposed to afterwards. This is known as stereotype threat in cognitive assays.
http://jop.sagepub.com/content/20/4/518.short
A result of this may be that obsession about negative psychedelic-related side effects may in fact exacerbate the phenomenon. Regardless, it is generally advisable in the event of significant difficulties to take a goddamn break because that will probably make you worry less, too.
http://www.erowid.org/archive/rhodium/pdf/hppd.review.pdf
The unpredictable side-effects of the psychedelic experience are in a large majority of cases quite mild. If you are experiencing significant effects, it is generally advisable to discontinue usage of both psychedelics and marijuana. Nicotine is mildly antipsychotic and in the form of an electronic cigarette or patch may alleviate the effects; it has in my experience. For your own sake, please do not smoke cigarettes. Pharmacological treatment, notably clonidine, is available; consult your physician if you feel you are experiencing side-effects severe enough to require treatment.
You're not a doctor, you're not describing anything like depersonalization:
http://en.wikipedia.org/wiki/Depersonalization
or schizoid personality disorder:
http://en.wikipedia.org/wiki/Schizoid_personality_disorder
so it's not entirely clear that what you're posting is in any way beneficial or useful to the cause of harm reduction. You are simply insulting another member: consider this a warning.
A remarkable feature of psychoneuroimmunology is that psychedelics can on occasion be able to modify the progression of autoimmune diseases, such as asthma:
http://www.erowid.org/experiences/exp.php?ID=15637
While very encouraging, the unpredictable nature of the psychedelic experience means that ordinary psychedelics are an unlikely treatment avenue. Psychosomatic effects can very easily take place in a negative direction and may include long-term anxiety, depression, and manic or fugue states. The propensity of individuals to develop such maladies may depend on preexisting mental factors, but these have not been characterized. Similar side-effects have been observed from meditative practices in which no drugs were used:
http://www.rickross.com/reference/brainwashing/brainwashing23.html
It is largely unclear what causes this. It is rather unlikely it is linked to any specific pattern of neurological changes. In particular, 5-ht2a agonists generally downregulate the 5-ht2a receptor, in common with agonists at other receptors. One would ordinarily expect this to coincide with sedation, a higher seizure threshold, lowered sociability, and a lower propensity for sensory distortion. My experience during periods of heavy psychedelic usage has been the precise opposite of all of this, with the exception of the seizure threshold (I have never had a seizure). That is to say that the long-term neurological effects of psychedelics do not in any simple way explain the long-term psychological effects.
One effect that is very real is priming, when a user expects an effect they are more likely to experience it, and so studies on drug users have, for example, shown that more drug-related impairment is measured if the subject is asked about his/her drug usage prior to completing an intelligence test as opposed to afterwards. This is known as stereotype threat in cognitive assays.
http://jop.sagepub.com/content/20/4/518.short
A result of this may be that obsession about negative psychedelic-related side effects may in fact exacerbate the phenomenon. Regardless, it is generally advisable in the event of significant difficulties to take a goddamn break because that will probably make you worry less, too.
http://www.erowid.org/archive/rhodium/pdf/hppd.review.pdf
The unpredictable side-effects of the psychedelic experience are in a large majority of cases quite mild. If you are experiencing significant effects, it is generally advisable to discontinue usage of both psychedelics and marijuana. Nicotine is mildly antipsychotic and in the form of an electronic cigarette or patch may alleviate the effects; it has in my experience. For your own sake, please do not smoke cigarettes. Pharmacological treatment, notably clonidine, is available; consult your physician if you feel you are experiencing side-effects severe enough to require treatment.
fixingahole said:You're obviously in denial about your depersonalization and schizoid tendencies. This is typical of well-developed and acute paranoid-schizophrenic symptoms, which your denial has confirmed.
You're not a doctor, you're not describing anything like depersonalization:
http://en.wikipedia.org/wiki/Depersonalization
or schizoid personality disorder:
http://en.wikipedia.org/wiki/Schizoid_personality_disorder
so it's not entirely clear that what you're posting is in any way beneficial or useful to the cause of harm reduction. You are simply insulting another member: consider this a warning.

