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1,1-bis(indole-3-yl)-2-dimethylaminoethane.png


ANGIE
1,1-bis(indole-3-yl)-2-dimethylaminoethane

Tryptamines are dark.
 
Too unstable, but I can't tell what you mean exactly without a structural diagram.

1-aza-2-methyl-3-phenyl-4-oxa-5-oxocyclohexane.png


5-OXO-PRELUDIN
1-aza-2-methyl-3-phenyl-4-oxa-5-oxocyclohexane

1-phenyl-1-acetoxy-2-methylaminopropane.png


O-ACETYL-METHAMPHETAMINE
1-phenyl-1-acetoxy-2-methylaminopropane

from ephedrine (I think. No idea here on how to protect and then deprotect the amine without hydrolyzing the benzylic OAc, or if N-protection is even necessary in this example. If not, just add some acetic anhydride and BAM!)

OAM, verdict: feels like relatively strong, smooth meth, but nothing like BOUNCE, its reverse ester, which is marvelous.
 
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1-(3,4-methylenedioxyphenyl)-1-methoxy-2-methylaminopropane.png


BACARDI_BAT
1-(3,4-methylenedioxyphenyl)-1-methoxy-2-methylaminopropane

I actually had some good pink MDMA Barcardi bats in like 2002.

Outline:

1-(3,4-methylenedioxyphenyl)-1-oxo-2-methylaminopropane.png


METHYLONE (pretty crappy)
1-(3,4-methylenedioxyphenyl)-1-oxo-2-methylaminopropane

then

1-(3,4-methylenedioxyphenyl)-1-hydroxy-2-methylaminopropane.png


1-(3,4-methylenedioxyphenyl)-1-hydroxy-2-methylaminopropane

Then the NaOMe Williamson Ether Synthesis And Viola!

No harsh, acid catalyzed nitrile oxidation step necessary.
 
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1-allyl-3,4-methylenedioxy-5-methoxybenzene.png


MYRISTICIN
1-allyl-3,4-methylenedioxy-5-methoxybenzene

KOH, alcohol, heat, reflux

1-propenyl-3,4-methylenedioxy-5-methoxybenzene.png


ISOMYRISTICIN
1-propenyl-3,4-methylenedioxy-5-methoxybenzene

Ozonolysis (Zn, HCl, O3+)

1-(oxomethyl)-3,4-methylenedioxy-5-methoxybenzene.png


MYRISTICINALDEHYDE
1-(oxomethyl)-3,4-methylenedioxy-5-methoxybenzene

an alkyl-amine (such as 1-aminocyclohexane or even CH3NH2) plus CH3CH2NO2 in CH3OH

1-(3,4-methylenedioxy-5-methoxyphenyl)-2-nitro-prop-1-ene.png


1-(3,4-methylenedioxy-5-methoxyphenyl)-2-nitro-prop-1-ene

NaBH4, alcohol

1-(3,4-methylenedioxy-5-methoxyphenyl)-2-nitro-propane.png


1-(3,4-methylenedioxy-5-methoxyphenyl)-2-nitro-propane

Sn/HCl, reflux

1-(3,4-methylenedioxy-5-methoxyphenyl)-2-aminopropane.png


THE_LEGENDARY_MMDA
1-(3,4-methylenedioxy-5-methoxyphenyl)-2-aminopropane

said to work best when combined with

1-phenyl-2-aminopropane.png


AMP
1-phenyl-2-aminopropane

Since 1887 by Lazaru.
 
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1-(3,4-methylenedioxy-5-methoxyphenyl)-1-methoxy-2-aminopropane.png


OLYMPIAN
1-(3,4-methylenedioxy-5-methoxyphenyl)-1-methoxy-2-aminopropane

(much more nearly legal than MMDA)

from

1-(3,4-methylenedioxy-5-methoxyphenyl)-1-oxopropane.png


1-(3,4-methylenedioxy-5-methoxyphenyl)-1-oxopropane

involving Br2 liquid and possibly sodium azide
 
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I just had this idea which may or may not be correct. If fastandbulbous reads this, maybe he could tell us.

3,4-methylenedioxy-5-methoxy-1-allylbenzene.png


MYRISTICIN
3,4-methylenedioxy-5-methoxy-1-allylbenzene

HBr(g) bubbled through THF

1-(3,4-methylenedioxy-5-methoxy-phenyl)-2-bromopropane.png


1-(3,4-methylenedioxy-5-methoxy-phenyl)-2-bromopropane

then sodium azide, NaN3

1-(3,4-methylenedioxy-5-methoxy-phenyl)-2-azidopropane.png


1-(3,4-methylenedioxy-5-methoxy-phenyl)-2-azidopropane

then NaBH4 in alcohol
 
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Alternatively, MYRISTICIN then The Wacker Oxidation Of Terminal Olefins followed by the ammonium formate Leuckart.
 
How to make ephedrine or ethylephedrine from benzene: benzene + CH3CH2(C=O)-Cl + AlCl3 -->

1-phenyl-1-oxopropane.png,
1-phenyl-1-oxopropane.png


1-phenyl-1-oxopropane + Br2

1-phenyl-1-oxo-2-bromopropane.png


1-phenyl-1-oxo-2-bromopropane + NH2CH3 (for ephedrine) or NH2CH2CH3 for ethylephedrine

1-phenyl-1-oxo-2-methylaminopropane.png


METHCATHINONE (jittery)
1-phenyl-1-oxo-2-methylaminopropane

or

1-phenyl-1-oxo-2-ethylaminopropane.png


ETHYLONE (weak)
1-phenyl-1-oxo-2-ethylaminopropane

then NaBH4

1-phenyl-1-hydroxy-2-methylaminopropane.png


EPHEDRINE
1-phenyl-1-hydroxy-2-methylaminopropane

or

1-phenyl-1-hydroxy-2-ethylaminopropane.png


ETHYLEPHEDRINE
1-phenyl-1-hydroxy-2-ethylaminopropane

Both are incredibly valuable precursors for METH, ETH, BOUNCE, and POUNCE.
 
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Please describe what you are referring to using another name or explanation.
 
Do you mean MDMA with the methylene-CH2- functional group replaced by an oxygen?
 
How to make propofol [FRANK]:

Phenol.png


phenol + HNO3/H2SO4 -->

4-nitrophenol.png


4-nitrophenol + 2 equivalents
CH3CH2CH2-Cl + AlCl3 -->

2,6-di-isopropyl-4-nitrophenol.png


2,6-di-isopropyl-4-nitrophenol + Sn/HCl -->

2,6-di-isopropyl-4-aminophenol.png


2,6-di-isopropyl-4-aminophenol + CuCl / NaN2 -->

2,6-di-isopropyl-4-diazophenol.png


2,6-di-isopropyl-4-diazophenol + H20 -->

2,6-di-isopropyl-phenol.png


FRANK (propofol)
2,6-di-isopropyl-phenol

That's the gist of it anyway. I may have gotten some of the reagents wrong.
 
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1-phenyl-1-carbomethoxy-2-ethylaminopropane.png


POUNCE
1-phenyl-1-carbomethoxy-2-ethylaminopropane

from benzene and propionyl chloride, etc.
 
(2R,6S)-2,6-di-isopropyl-cyclohexanone.png


WELDON
(2R,6S)-2,6-di-isopropyl-cyclohexanone

(2R,6S)-2,6-di-isopropyl-cyclohexane-1-ol.png


ABIGAIL
(2R,6S)-2,6-di-isopropyl-cyclohexane-1-ol
 
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1-(4-isopropyl-3-methoxyphenyl)-2-aminopropane.png


LIL_FRANK
1-(4-isopropyl-3-methoxyphenyl)-2-aminopropane

Thyme Thyme
Ask Cyndi Lauper

from thymol

1-methyl-4-isopropyl-3-hydroxybenzene.png


1-methyl-4-isopropyl-3-hydroxybenzene
 
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