N&PD Moderators: Skorpio
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Rectify
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NOVEL_T
1,7-diphenoxyperhydropyrrolizine
CLAY
1,7-diphenylperhydropyrrolizine
STEFAN
1,7-di(3,4-methylenedioxyphenoxy)perhydropyrrolizine
STEFANIE
1,7-di(3,4-methylenedioxyphenyl)perhydropyrrolizine
Saving The World, One Drug At A Time.Smyth2
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REED looks like this compound in my database:
REED
1-phenyl-1-(2-pyrrolidinyl)methane
Cmp 22
cis-2,5-Di(2-benzyl)-pyrrolidine
https://pubchem.ncbi.nlm.nih.gov/compound/44598295
Vartak, A. P., Nickell, J. R., Chagkutip, J., Dwoskin, L. P., & Crooks, P. A. (2009). Pyrrolidine Analogues of Lobelane: Relationship of Affinity for the Dihydrotetrabenazine Binding Site with Function of the Vesicular Monoamine Transporter 2 (VMAT2). Journal of Medicinal Chemistry, 52(23), 7878–7882. https://doi.org/10.1021/jm900770hRectify
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cis-ANETHOLE (from Star Anise Essential Oil)
The Star Anise Oil (cis-anethole) Amphetamines: PMA, PMMA, & PMEA. I Took A Pink Superman PMA (or 3) And Loved It Circa 2002/2003. However, That Was Also When MDMA Still Worked. Did The Star Anise Amphetamine Family Lose Its Luster Like The Safrollers? I Really Doubt They Did. Or Is Ecstasy Much Harder To Source Nowadays, Based On It's Reputation As "a gay drug"? Magic 8-ball: Signs Point To Yes.Smyth2
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I thought it was trans-anethole.
cis-ANETHOLE (from Star Anise Essential Oil)
The Star Anise Oil (cis-anethole) Amphetamines: PMA, PMMA, & PMEA. I Took A Pink Superman PMA (or 3) And Loved It Circa 2002/2003. However, That Was Also When MDMA Still Worked. Did The Star Anise Amphetamine Family Lose Its Luster Like The Safrollers? I Really Doubt They Did. Or Is Ecstasy Much Harder To Source Nowadays, Based On It's Reputation As "a gay drug"? Magic 8-ball: Signs Point To Yes.
Anyway, it is the starting material to make estrogens from also. Agents like Anol,
and it was found that dimerization of anol into dianol and hexestrol can rapidly occur and that the latter impurity was responsible for the highly potent estrogenic effects.Smyth2
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[1] Deutsch HM, Shi Q, Gruszecka-Kowalik E, Schweri MM (March 1996). "Synthesis and pharmacology of potential cocaine antagonists. 2. Structure-activity relationship studies of aromatic ring-substituted methylphenidate analogs". Journal of Medicinal Chemistry. 39 (6): 1201–9. doi:10.1021/jm950697c. PMID 8632426.
[2] Schweri MM, Deutsch HM, Massey AT, Holtzman SG (May 2002). "Biochemical and behavioral characterization of novel methylphenidate analogs". The Journal of Pharmacology and Experimental Therapeutics. 301 (2): 527–35. doi:10.1124/jpet.301.2.527. PMID 11961053.
3’,4’-Dichloromethylphenidate
[1364331-88-3]Rectify
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SASSAFRAS_OIL
1-allyl-3,4-methylenedioxybenzene
WACKER (mdp2p; pmk) OXIDATION PRODUCT
1-(3,4-methylenedioxyphenyl)-2-oxopropane
The Leuckart Reaction:
1) NH2(C=O)H
formamide
2) LAH / THF
3) HCl(g) / diethylether
ECSTASY (mdma.hcl)
1-(3,4-methylenedioxyphenyl)-2-methylaminopropane hydrochlorideRectify
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BOUNCE: (also know as Pink Cocaine) 1-carbomethoxy-2-methylamino-3-phenyl-propane.hcl
Believe The Hype! God Like Focus. Makes You Want To Dance. Mental Clarity. Energy. Euphoria. An Introverted Amphetamine.
Made From Ephedrine, A Natural Product Alkaloid, In 4 Reasonably High Yielding, Energetically Favorable Steps.
R-OH --> R-Cl --> R-CN (a nitrile) --> R-(C=O)-OH --> R-(C=O)-O-CH3.Rectify
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