Thw problem with many analogues is there extreme short duration. I did wonder WHY the original designers went with brotizolam and the reason was, among other things, that it had the longest duration of the (sub)class.... and when you consider just how brief the action of brotizolam is, you can see just how rapidly the homologues are metabolised....
It IS possible to push up that duration beyond brotizolam, but the complexity or the synthesis reached 14 or 15 steps, none of them combinational. It's a long slog.
For the overall yield, something like diclazepam is MUCH cheaper. I often wonder if the makers are now asking crazy prices and the vendors just ACCELP those prices. I think 100 x 2mg diclazepam retailed at about £35, which is not bad - cheaper then 'street valium' that isn't even diazepam.
I'm quite glad that the notribenzodiazepines have not turned up much - they are MUCH more toxic. Take 1g of diazepam - sleep for a week. Take 1g of nitrazepam (or flunitrazepam clonazapam or such) and it's very likely fatal. MAYBE they were made and DID kill sufficient people to make them a bad target. Horrible way to run a business - but it doesn't look like most current vendors have any novel ideas or even understand medicinal chemistry, which is a shame. I guess they are costly and they don't end up giving you MORE designs.... they just give you SFAE designs, which make no more money.
and i really liked their short-duration hypnotic effects. I'm never gonna dance again.
