yes. This is a pretty basic question, so I'll kick it over to BDD.
If you haven't done tramadol ever... I would start with 50 or 100mgs. I have known *many* people to get floored by taking too many because of the combined mu opiod and snri activity. Personally, the first time I got prescribed them, about when they came out, I was all like, oh fuck this, I didn't even get opies and ate like 4 or 5 (of the 50mgs) well I was in college at the time and had to go to my 5 hour long lab of which I remember about 20 minutes. The teacher woke me up at the end and let me know that I looked too wiped out to wake up. FML.