Gabapentinoids Pregabalin instant-fast tolerance

[dopamine seeker]

So just to point out. Pregabalin is one of my favorite drug. It has an euforic effect like mdma, makes you happy and sociable. but...
yesterday I took 825 mg and had that awesome feeling, happy, talkative and everything plus: it doesn't have comedown like amphetamine or others.
today I took 825 mg again and it almost had zero effect. I take it everyday 600 mg but spaced out. Always when I take 300 mg I get a good mood lift. But today it didn't work at all, as I took yesterday at night, just didn't work today. I want to know if this is just a stable and high blood plasma concentration of pregabalin, so like methadone, it just doesn't make you high after the first times, or is it tolerance, like fast tolerance ? I apreciate you reading this, and if someone can explain me it better I would be glad to know.

 

[Juniper Bruhmomentius]

Generally, pregabalin has to be dosed 3x the second day of using to get a same effect as day 1.

Its the fast tolerance. 300mg will propably start working again somewhat after you have taken it for some time.

 

[PtahTek]

^^^ Agreed.
That tolerance builds super-fast in my experience with pregabalin (lyrica). Makes me feel drunk in a pleasant way but not sustainable without looking to go through some extended withdrawals upon cessation.
Careful with pregab... even taken as prescribed over as little as a couple-three weeks can bring WDs if not tapered off.

 

[SAT4N_420]

Unfortunately that's normal. I find that the best way to use pregabalin is to at least have 3 days between each time you use it, of course the more you wait the better.

 

[Zonxx]

In August of 2019 while using up to a gram of adderall/day i started using gabapentin WITH pregablin at the same time, by the end of the month a regular dose was 30-50,000mg of pentin and 4-9,000mg of pregab.... don't use it often, you will regret it.