Post a chemical that you think has some serious potential to become a winner in the RC market

[Smyth2]

Methyl 3-amino-2-phenylpropanoate
[99092-02-1]

The new compounds of formula I are fast-acting stimulants of the central nervous system. They can be administered orally or parenterally and are not very toxic. They are suitable for treating mental depression, a result of nervous exhaustion, chronic fatigue and drug therapies.
Catalytic hydrogenation of Ethyl phenylcyanoacetate [4553-07-5]
https://www.sciencemadness.org/talk/viewthread.php?tid=158504
"ETHYL PHENYLCYANOACETATE". Organic Syntheses. 30: 43. 1950. doi:10.15227/orgsyn.030.0043.
Vitvitskaya, A. S., Naidis, F. B., Katsnel’son, E. Z., Karpinskaya, I. A. (July 1981). "Synthesis of ethyl cyanoethylphenylacetate". Pharmaceutical Chemistry Journal. 15 (7): 512–515. doi:10.1007/BF00758539.
Frederick Dr Leonard, CH369764 (1963 to Geigy).

 

[fastandbulbous]

3C-BOD
4-methyl - 2,5,beta-TMA
I like BOD so why not the 3 carbon version.

Just strip off all the ring substitution, N- methylate the nitrogen and you have O-methylephedrine. By methoxylating to OH group of ephedrine, you remove just about all the shake adrenergic effects and you've got a new method (chirality on the beta carbon has no effect on CNS stimulators activity). If you feel like mixing it up a bit, you can go for O-acetyl ephedrine - a rather pleasant drug that is piss simple to make from ephedrine (easier & safer than meth)

 

[fastandbulbous]

I previously posted a paper about these, but here are their structures. These sound promising.

3-APBT

5-APBT

6-APBT

Wouldn't touch anything with sulphur in the position of catecholamines oxygen as they tend to turn up drugs that a potent MAOIs, which also cause massive 5HT release (a recipie for disaster)

 

[fastandbulbous]

I would really like to see 5-MeO-MPMI and 4-HO-MPMI come onto the RC market!!

Both are reported to be around the same potency as DOI so both are active well under 2 mg.

Just cautious about the ethylamine
Nitrogen being incorporated into a ring

 

[fastandbulbous]

1-phenyl-1-carboethoxy-2-methylamino-propane

from

1-phenyl-1-hydroxy-2-methylamino-propane

1-phenyl-1- hydroxy2methylaminoprooane is a.k.a. ephedrine, which is watched like hawk, because of it's role in a quick way to make meth

 

[Rectify]

Yes, But Ephedrine Is Also A Natural Product Made From A Grass Which Could Be Farmed By The Ton.

 

[Smyth2]

That's all right if you only wanted a herbal tea but if you want pure alkaloid it isn't going to be effective.

 

[4DQSAR]

I think it important to note that everything you will find in patents or academic papers were almost all intended for human usage because that is where all the money is.

So if a candidate from decades before doesn't even make it to human trials. Ask why. - Also be aware that as things stand, pharmacutical manufacturers are NOT required to publish any human trials.

That's why I support www.alltrials.net

I was especially disgusted to learn that a compound very similar to Super-MAB (Theralizumab) HAD undergone human trials and the dangers were known to the original researchers - but as Napoleon Bonepart observed 'N'interrompez pas un ennemi lorsqu'il fait une erreur'. In short - the ONLY benefit in publishing would be to warn off other researchers and prevent the wasted investment. Ethics don't even come into the picture.

 

[Smyth2]

Look at this page i'm writing here: https://en.wikipedia.org/wiki/Draft:Diacetonamine#Applications

 

[TheLightBringer]

Look at this page i'm writing here: https://en.wikipedia.org/wiki/Draft:Diacetonamine#Applications

Interesting, says that it acts as both a stimulant and depressant. Any guess as to its pharmacological activity?

 

[4DQSAR]

Interesting, says that it acts as both a stimulant and depressant. Any guess as to its pharmacological activity?

But surely the wealth of Victorian era references should make that obvious?

 

[TheLightBringer]

But surely the wealth of Victorian era references should make that obvious?

?