FreedomCalls
Bluelighter
- Joined
- May 20, 2019
- Messages
- 74
I just made some poppy seed tea and I'm wondering if there is any danger to plugging some of it, it tastes absolutely disgusting.
Has anyone done this?
Has anyone done this?
The area of the rectum that absorbs straight to the bloodstream is only about 6 centimeters, the majority, esp when laying on your side all goes through the hepatic portal vein, making the uptake and 1st pass metab. about the same as the stomach, minus all that extra surface area in the stomach.you might wind up with a surprisingly high dose of highly soluble aqueous morphine being efficiently absorbed by the rectum
The bioavailability of morphine after rectal administration was found to be 53.3 +/- 17.8% (mean +/- S.D.). Peak concentrations of 16.3 +/- 8.7 ng ml-1 were reached after 59 +/- 16 min. The study indicates that first pass elimination of morphine may be partially avoided by rectal administration
https://bjanaesthesia.org/article/S0007-0912(17)42397-X/pdfPhysiological factors influencing rectal drug absorption,Two factors are of major importance with respect to the venous drainage of the rectum and consequently the transport of absorbed drug into the systemic circulation: site of absorption and direction of blood flow. If the drug is absorbed in the upper part of the rectum, it is transported to the portal system and passes through the liver. While, following absorption in the lower rectum, the drug is transported directly to the systemic circulation. In general, this implies that hepatic first-pass elimination is avoided when a drug is administered in the lower part of the rectum.
Probably wont work that well, since the process of shaking the seeds releases oils that, as i hypothesize, form liposomes around the alkaloids which make it only really suitable for oral use (the liposomes wont open up just sitting in your rectum).
What you might do however is heat the tea for a while which I found breaks open the liposomes and liberates the alkaloids into the solution. This might work better. The plus side to this too, is that it will at least semi-sterilze the solution to perhaps lower the risk of infection. Another approach would be to defat the poppy seed tea to avoid putting the oils in you. You might be able to do this by first heating to liberate the alkaloids, then freeze to separate the fat.
Presumably the liposome formation is why poppy pod tea lasts 21 hours, whole plant tea 17, and poppy seed tea 8 hours . . .
I've only used phenadoxone up the arsehole successfully and it was nice, but then I lost the range of motion to do that correctly and not waste/destroy medication about two years later.
Poppy seed oil and the resins and other oils in the tea will make it more comfortable and I would make sure the pH is no lower than about 5 before squirting it up there.
The area of the rectum that absorbs straight to the bloodstream is only about 6 centimeters, the majority, esp when laying on your side all goes through the hepatic portal vein, making the uptake and 1st pass metab. about the same as the stomach, minus all that extra surface area in the stomach.
Although there was a thread from NP&D lost in the prune that had data backing up a massive increase in rectal BA by deprotonation of the MS. It wasn't quite high enough to liberate it from it's salt and precipitate to base, but was close from what I hazily remember. If you come across anything like that Negrogesic, please let me know. Thx.
Also with Morphine being the main desired constituent of Poppies/ Opium/ tea, here's some articles on it.
The bioavailability of rectally administered morphine - PubMed
Plasma concentrations of morphine were followed for 24 hours in eight patients after intravenous and rectal administration of 10 mg morphine chloride. The plasma levels of morphine were determined by a sensitive and specific radioimmunoassay based upon an extraction procedure which separates...www.ncbi.nlm.nih.gov
https://bjanaesthesia.org/article/S0007-0912(17)42397-X/pdf
I guess you really have to be a stand-up Guy/Gal to bypass that hepatic portal.
View attachment 14690
The risk is, if the brew is strong (the liposomes actually reduce OD risk via the slow release, where as the heated and partially evaporated solution would be morphine in aqueous solution), you might wind up with a surprisingly high dose of highly soluble aqueous morphine being efficiently absorbed by the rectum...ie., you might wind up with a dangerous amount of morphine in your bloodstream. Still, id be curious.
poppy seed tea 8 hours
Well that's the reason for my concern. PST can be VERY strong and if it's absorbing much more rapidly with a higher BA, without time release... could easily lead to OD.
I was addicted to opiates for 10 years and poppy seed tea was what I settled on out of everything, and it lasted a good 20-24 hours for me... I could dose it at noon and not even need to dose he next day until night time, it lasted forever.
Does anyone ask themselves"wtf am I doing" or "have I taken this too far" when your on the bathroom floor upside down with a turkey baster hanging out of your ass for nonsexual purposes?
Right up until the point when it kicks in and works like magic.Does anyone ask themselves"wtf am I doing" or "have I taken this too far" when your on the bathroom floor upside down with a turkey baster hanging out of your ass for nonsexual purposes?