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  • BDD Moderators: Keif’ Richards | negrogesic

plugging med's up your butt..WHY

When you take something - anything - orally it goes to your stomach, and then small intestine where it then gets absorbed into the bloodstream.... This blood flows directly to the liver where many drugs are metabolised to some degree, before they then go off to the brain where they produce the effects...

This is known as first pass metabolism.

When you plug drugs, they get absorbed into the bloodstream and this blood flow bypasses the liver and heads straight for the brain, thus avoiding any first pass metabolism... Basically getting more bang for your buck.

Take MDMA for example... With an oral dose only about 50% reaches the brain and produces an effect. When you plug the same dose, approx 90% will reach the brain. In effect, by plugging you are double dropping... Plus I believe there is a quicker onset of action...
 
^ Do you have any document to back up that claim of MDMA's bioavailabilities for those ROA's?
 
Read the thread, and all the post's.
I got a question.
It takes about 5 5/500mg hydro's for me to get a good buzz. Thats alota acet.. not enough to be fatal, but more than I want to deal with.
So im considering rectal ROA for once. So if it takes me 5 5/500 orally. What is recommended for plugging? O.o I feel weird just asking the question. But yes tell me how much to shove up there for the same results of orally ingesting 5, 5/500 hydro's.
Thannnnks.
 
Sorry dude, wouldn't know about that - could try any find out... Your right about that much acet not being fatal - anything over 4000mg and you need to start worrying, but it is still giving your liver a bashing... Whatever the ROA, it will reach your liver eventually tho...

Why not do a CWE? Really simple to do and removes almost all of the acet and left with just the opioid/opiate which is what your after...
 
Well because from what I've heard it helps conserve aloootttt. And atm I only have 2 5/500 hydro's. I've done CWE once but I used 20 of em. 2 would be useless.. And People on here say when you plug, not near as much acet. gets absorbed.
 
For small amounts like that then I see any adverse effects with plugging them then... I'd imagine you'd get a stronger opiate effect and with that little amount of acet you'd have nothing to worry about...
 
^ Oxycodones bioavailability rectally is the same as oral. Since both hydro and oxy are of the same class of opioids, I'd imagine it would be the same. But you'd still get a quicker onset, without some side effects, but probably nothing to gain with bioavailability. I'd give it a try. Start with 4 x 5/500 crushed up.
 
Lmao, crushed up? I dont exactly understand... do i have a friend blow it in there with a straw XD. Im kidding, but forreal is there like some "tool" for this type of ROA?
 
Self_Cultivated said:
Lmao, crushed up? I dont exactly understand... do i have a friend blow it in there with a straw XD. Im kidding, but forreal is there like some "tool" for this type of ROA?
Click to expand...

p_2509_FS0333.jpg


mix it with a bit of water.
 
L.M.F.A.O. I've seen one of those is my moms room when i was like 15 xD!!!!!!!!!!!!!!!!!!!!!!!



Siiiiiickkk,

I'll give it a try I guess :/
 
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It's really not as big a deal as everyone makes it. After the initial "Oooohhhh" feeling, there's not much else.
 
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