Please confirm this nomenclature

[LuxEtVeritas]

I am not confident in my somewhat rusty nomenclatural skills and would like someone to confirm the correct nomenclature for the amide ring closed analogue of 1-(Benzofurazan-5-ylcarbonyl)piperidine

TIA

 

[dorothyperkins]

Ring closed how? Like this?

I dunno if this is right for benzofurazanyl, its what chemdraw came up with.

 

[MattPsy]

Yeah I wasn't sure how to close the ring... I figured just another 6 membered one. ^ You seem to think 5. Argh
(I expect both are active thou).

 

[Ham-milton]

Active as what? Psychedelics???

 

[MattPsy]

No, as allosteric glutamatergic AMPA agonists. aka ampakine-type drugs.

 

[LuxEtVeritas]

anyone wish to venture whether the 5- or 6-membered C-ring closure would be more metabolically stable?

 

[dorothyperkins]

6-membered how? Like this? If so the amide carbonyl in the 6,6 one looks more hindered than the 6,5 one.

Edit: Interesting, never heard of them, anyone try one?

 

[MattPsy]

This is what I came up with (posted on request)...

 

[Ham-milton]

I guess I haven't paid much attention to AMPAkines, apparently.