What if you take it with a choline supplement?"It exerts an apparent cholinergic effect but only by inhibiting choline uptake."
.Another reputed effect of DMAE supplementation is a rise in choline and acetylcholine levels and a corresponding increase in memory ability. This is based on the assumption that DMAE is a choline precursor [1] and also crosses the blood brain barrier more effectively than choline itself [9], giving it the ability to reach the brain and then increase brain choline levels. DMAE does consistently increase levels of free choline in the brain and body, but this is not because it is a converted to choline – it is because it competitively inhibits choline kinase and choline oxidase, preventing the metabolism of choline to phosphocholine and betaine [10-12]. As mentioned above, this results in the production of phosphatidyl-DMAE. However, this is not necessarily beneficial, since it replaces phosphatidylcholine, and thus may effectively blunt some of the biological actions of phosphatidylcholine [39].
There is very little evidence that this increase in choline levels leads to a consequent rise in acetylcholine, and given that DMAE competitively inhibits choline transport, there is theoretical basis for an anticholinergic effect [10-11, 13-15]. If anything, this renders DMAE supplementation the equivalent of choline supplementation, since that also increases brain choline levels but generally fails to increase acetylcholine [16]. In an in vitro study, DMAE reduced the synthesis of acetylcholine by inhibiting high affinity choline transport, and the same researchers found no effect of DMAE on acetylcholine levels in vivo in rats [17]. In another study in which a wide range of doses of DMAE was administered to mice, there was no increase in brain acetylcholine levels except an increase in the striatum at the highest dose which appeared to be unrelated to tissue DMAE content [18]
In one study, rat pups fed a choline-deficient diet containing DMAE died within 36 hours of birth, supporting the notion that DMAE does not function as an effective choline precursor [37]
INGREDIENTS: What are the ingredients of BrainQUICKEN (Cognamine)?
BrainQUICKEN is the best available combination of safety and efficacy: Just one of the 18 active components, vinpocetine, has been demonstrated to increase short-term memory and reaction speed over 35%. [BT: Emphasis added - vinpocetine is the nootropic in this formulation, not piracetam.]
BrainQUICKEN consists of a select group of compounds proven safe in the food supply over a 10-year period, and BrainQUICKEN does not contain any ephedrine, ephedra, ma huang, yohimbine, or other dangerous stimulants.
Top research and over 60 years of manufacturing experience have combined for the first time to create the most effective and science-driven neural accelerator in existence. Our patent-pending design includes specialized and clinically-tested ingredients such as:
Cobalamin, Niacinamide, Folic Acid, 2-dimethylaminoethanol, Pyridoxine HCL, Pantothenic Acid (Calcium Pantothenate), Proprietary Cognamine™ Complex (including components of: Phosphatidylserine, Choline Bitartrate, Vinpocetine, Salix Alba, Thioctic Acid, L-Tyrosine, Ciwujia, and other synergistic compounds)
lostNfound said:I recover from weekends fairly quickly and I get stuck on any emotional rollerocaster rides of any sort.