is there any actual real evidence that ibogaine is effective for treating opiate withdrawal?
all i've ever seen are like testimonials and stuff, seems kinda sketch tbph
i guess i could jsut google search
Hey Rog, there is a lot of hocus pocus mumbo jumbo amongst the "Ibogaine community" about it "resetting the brain" yada yada....but pharmacologically it isn't as much of a mystery as most seem to think it is...
Check this out:
http://www.ibogaine.desk.nl/ch02.pdf
Check out the human and binding studies Debora Mash did, or the work by Stanley Glick up at AMC...cool guy...
Shit ton of animals studies on PubMed and Wiley, etc too....18-MC is some pretty fascinating stuff too....I've been communicating with one of the researchers for the patent holders for awhile...they recently got like an 8 million dollar grant from the NIH for human studies....I'm trying to weasel my way in there
Those numbers in the first link should explain it to ya! It all makes sense pharmacologically.....Ibogaine, and especially it's primary metabolite nor-Ibogaine, have significant affinity for the MOR, as well as the delta and kappa....when you are taking over a gram of the stuff it "stopping withdrawal" is basically guaranteed, even for heavy duty IV heroin addicts. Nor-Ibogaine is very fat soluble, and can be detected in the blood for weeks post administration, thus making the smoothest taper off ever....plus it's ki at the NMDA receptors is nothing to sneeze at, and nor-Ibo is a potent SRI....look at the chart, they are very messy drugs, in the best possible way for an opioid addict...Hit everything you could possibly want them to to assist in such an ordeal....And hit the receptors you want for all the post acute stuff too..
Enough affinity for 5HT2a to be classically psychedelic, but it's activity at the kappa and NMDA receptors almost lend more to the experience IME....very dreamlike and dissociated, yet you remain pretty damn lucid...amazing closed eye scenes, and incredible classic tryptamine visuals with eyes open. I was still seeing wicked tracers in the morning and evening for 4 days last time. The main effects are about 24 hours long....it is very intense psychologically, but never fearful, whatsoever....pretty amazing stuff. It just gives you a door to step through, the rest is up to you..
I keep intending to write up a TR summarizing my two experiences, and laying out the pharmacodynamics in lay mans terms, but have been too busy..
Xorkoth, you have nothing to fear, it just takes you, and you've got plenty of experience under your belt. Would *strongly* suggest staying away from the buprenorphine before however.....they dont play nice together. The 37.5 hr mean half life of bupe does Ibogaine no favors, and the kappa antagonism of bupe presents a problem. Stick with the seed tea.....you are doing it like every other day, yeah? Just stick with that, and lower your dose as much as you can prior, and be as sick as you can. Ibogaine at +1g will blow those withdrawals out of the water, and give you an amazing oneirogenic experience to boot. The lack of cravings afterwords is oh so nice as well.
I been meaning to post some more details and answers to your questions in the Ibogaine thread, I will, just been busy as hell lately...springtime, farming and all.....bare with me! I think it is exactly what you need, and you are the ideal candidate man. Soon you will be free of those pesky opioids :D