I think the deaths from 5-MeO-DMT are usually due either to vomit aspiration, drowning, or drug interactions. Ibogaine affects heart rhythms in multiple ways, of which QT prolongations is but one. I have not heard good reports of people being treated effectively when it gets bad. Lots of drugs cause QT-prolongation. Some (Benadryl) don't seem to be that risky. Others (methadone) are apparently roughly equivalent to ibogaine. The number of recorded ibogaine fatalities when I last checked was 17, although there are undoubtedly more. I've read of at least one in a pseudo-clinical setting where it was not reported because of concerns regarding the surviving partner's life insurance payout. The fact that deaths can occur days later also complicate attempts to measure them. I think that efforts to screen for risk factors (dehydration, methadone use, pre-existing heart conditions) are a positive step, but I don't know that we'll have good data for many years as to how effective they are at completely screening out risk.
Yeah, Iโm sure thereโs more than we think, but itโs still not a lot compared to basically anything else that can kill you. I was mainly pointing it out because SuperPsych was just raving about DMXE. Even ketamine kills many times more people a year than ibogaine and 5-MeO-DMT combined and Iโm not trying to call ketamine particularly deadly by saying that.
After ten years of tripping, my friend finally tried nitrous last night. They had an experience that I'd read about plenty, but neither of us had experienced before: they took 20mg of miprocin, and after two hours had not gotten above a very, very weak +. They are exceedingly experienced with miprocin, and knew that 45min was the absolute longest they should ever expect to wait, even on a full stomach. They were frustrated and were tempted to take a 5mg booster. I said, just take the loss and call it a night. I suggested taking a few balloons of nitrous, as that will often kick my brain into recognizing that it's tripping. I told them to take several lungfulls back to back, holding them in, but apparently holding one cartridge worth for ten seconds was plenty intense. It never got them going. They vaped some EPT sullenly and gave up.
Three hours after dosing, they suddenly started tripping. Only a light, attenuated ++ likely due to tolerance, but a big shift. Very weird.
Iโve seen that happen and experienced it but I think capsules were always involved. Hereโs an excerpt from my 50 mg report where I happened to use one:
โMost notable to me at first was that the capsule seemed to drastically slow down the onset from how I'm used to eating it just straight; I'd normally feel that kicking in hard within about fifteen to twenty minutes, but this time at about an hour I was honestly starting to wonder if the chemical had somehow degraded despite the fact that it still looked completely white. However, just as I was having these thoughts, I moved my hand and there they were: tracers, tracers, and tracers of tracers. They went from nothing to almost blinding, creating too many copies to see through the spaces of, stacking upon each other, and just floating in front of me wherever I tried to look.โ
It was weird. No more capsules.
Nitrous does help me with that too most of the time. I used to do it at the beginning of every trip.
The following morning, a different friend told me that they couldn't sleep, so they hit their wax pen. Ended up in hyperspace. Full moon? lol
This is how those experiences always happen for me. THC when youโre tired but canโt sleep in total darkness is like a dissociative without the anxiolysis.
My one dose with it was on the low end and while it was not the craziest of experiences by any means, it definitely left me with an evil aftertasted that lasted all week.
I do remember this about your experience but for what itโs worth, I think most of the reputation probably came from the trips themselves. I was a big fan of reading those early DPT trip reports back in the day, they were almost as โhilariousโ as salvia and datura reports. There were literally almost none of them below 100 mg insufflated, some involving multiple doses, and going at least as high as 250 mg, and often involving multiple friends doing it at once just because they heard that itโs strong. Itโs nuts but itโs not like I can really blame people with the lack of information that was available at the time, they were mostly the DPT pioneers.
I wanted to revisit 4-AcO-DET. I haven't had the 4 hydroxy sub, but so far this one doesn't feel all that weird or alien. I quite liked it the two times I tried it.
To be clear, itโs the same as DPT for me, where itโs just superficial and not about how it โfeelsโ for me. Iโve taken both 4-HO-DET and 4-AcO-DET and they both feel astoundingly โnormalโ to me, almost like psychedelic deliriants. And yes I do say that also because they look alien and demonic.
Smoking 30 mg of 4-AcO-DET is actually the most Iโve experienced this visual quality from anything in most ways, the few exceptions being some 5-MeO-EiPT-relatedโฆ things. But at the same time my feeling was just enthralled and manic, in a detached way. It was the most visually crisp psychedelic trip Iโve probably ever had with realistic painting-like imagery being significantly more common than any sort of geometric or other sensory effects. I could feel the life in the demons who I could see watching me and sense that they expected me to be a shaman who would conquer the netherworld with my love and unite the forces of light and darkness. Smoking 30 mg of DPT produced a trip that was similar but with less going on, more dissociative and distanced.
5-MeO-PiPT is pretty different from the -MiPT in my experience, too.
Iโd like to try it one day. I bet itโs more soft.
Like when I've had to take a crap while tripping I'll be getting sucked into the tippy wallpaper and will be tripping quite hard but as soon as I'm walking around again I'm barely tripping.
โShitting on Acid.โ I knew some guys in college who wanted to write that book.
I had a perma-tolerance after my years of tripping WAY too often (but note that even once weekly tripping for a long time will produce quite a bit of "perma-tolerance"). It took me 3 solid years to start to get my ability to fully enjoy psychedelics back, of not tripping even once (well I did once after about a year and a half, but only confirmed I still had a monstrous tolerance).
Even once I started again, I still had a higher than normal tolerance. But the good news is that, years after that, of not tripping very often or with any constant regularity (that is, I might trip 2 weeks in a row, or I might take 2 months off, I am not ever just counting the day until my next trip), I have the least amount of tolerance I have ever had. I seem actually more sensitive to psychedelics than I was even when I started. Which is awesome.

For years I thought I had fucked myself over for life.
This is pretty much how it went for me too. Itโs easy to feel sad about โnever getting to trip / trip hard againโ but in my experience thereโs never any guarantee you wonโt be back in it again eventually.