Zonxx
Bluelighter
Is grapefruit juice really that effective, anyone have any experience?
Yes, juice should definitely work as booster for oxycodone!Is grapefruit juice really that effective, anyone have any experience?
Well im a HEAVY opiate user and oxy is only my breakthrough med so not worried about od but do you think since it inhibits that the oxy'll build up over a few days, and with that in mind ( the buildup) cause tolerance to increase ( i like my oxy tolerance where it is =p)Yes, juice should definitely work as booster for oxycodone!
Grapefruit juice blocks or rather say Inhibits liver enzyme called CYP3A4, oxy's primary liver metabolism goes by the same enzyme, so blocking it should cause this process to stop/stall, as the result, oxycodone's effects will last longer, but be very careful! This might cause an overdose even with therapeutical dosages! Start carefully with small amounts of juice because everyone knows how easy to OD with opioids/ates even w/o any boosters.
Oh, and juice enzyme inhibition will lasts up for 3 days, keep this in mind
Well, juice's furanocoumarins aka enzyme inhibitors excrates much more faster, but depends from the strength of inhibitor, might cause lack of the enzyme itself, and it needs time for your body to produce it back to normal amounts. That's why 3 daysWell im a HEAVY opiate user and oxy is only my breakthrough med so not worried about od but do you think since it inhibits that the oxy'll build up over a few days, and with that in mind ( the buildup) cause tolerance to increase ( i like my oxy tolerance where it is =p)
Haha yeah my oxy dose isnt remotely as high as my morphine, but yeah gots to always be careful with these things wonder whatd happen if someone were to chug a bottle of grapefruit juice, take a high dose of oxy, and chug a bottle of the juice everyday ya think that one dose of oxy would last for days? Good theory no? Or to constantly drink juice throughout the day for days what a blessing it would be to only have to take one dose every few days hahaWell, juice's furanocoumarins aka enzyme inhibitors excrates much more faster, but depends from the strength of inhibitor, might cause lack of the enzyme itself, and it needs time for your body to produce it back to normal amounts. That's why 3 days
A warning was just to.. What a surprise, to warn you :D
The dosage of oxy lasting for days is lethalHaha yeah my oxy dose isnt remotely as high as my morphine, but yeah gots to always be careful with these things wonder whatd happen if someone were to chug a bottle of grapefruit juice, take a high dose of oxy, and chug a bottle of the juice everyday ya think that one dose of oxy would last for days? Good theory no? Or to constantly drink juice throughout the day for days
I see i see, even if the dose were not enough for a nod, but enough to get a sweet spot?The dosage of oxy lasting for days is lethal
That's why we redosimg instead of taking all at once :D
From my research last night it extends the 'peak' time by approx 1.5x so it lasts 50% longer aswell as increases peak concentration by 1.2-1.4x so 20-40% stronger in effects aka high/painkilling but every individual is different aswell as i could not find info determining if you chug a litre vs a glass, but you MUST drink a decent amountAlso does it only effect the high feeling or does it also help the pain killing effect for those of us in chronic pain
it has to be the grapefruit juice with pulpI'm not sure which type of grapefruit you need to use. I guess it would have to be fresh (real) grapefruit juice.
EDIT: I've never tried it so I can't comment on whether it makes the high better or whether it lasts longer.
From my research last night it extends the 'peak' time by approx 1.5x so it lasts 50% longer aswell as increases peak concentration by 1.2-1.4x so 20-40% stronger in effects aka high/painkilling but every individual is different aswell as i could not find info determining if you chug a litre vs a glass, but you MUST drink a decent amount
it has to be the grapefruit juice with pulp
Actually the BA is 60-87% to start with but yeahSo fresh (chilled/refrigerated) grapefruit juice? I wanna try this out. Your saying it could potentiate upto 40%? If so ur looking at a BA of 100-120%! That would be equivalent to IV Oxycodone. Oral Oxycodone has a BA of ~80%, so if you drink grapefruit juice your theoretically getting back the 20% and exceeding it too ( upto 40% ) lost through first pass metabolism via orally taken. I hope that makes sense lol