rachamim
Bluelighter
Sorry if my info will be redundant because of having been offered by another poster but I cannot honestly fully read 240 posts and yet this subject needs to be discussed.
Loperamide is a great lesson ins what is and what is not an opioid. Structure is not what determines a substance's classification and indeed Loperamide is structured very nicely. The problem though, and I will not bore folks with the chemistry is the substance's inability, EVER, to cross the Blood to Brain Barrier (BBB) UNLESS directed DIRECTLY into a person's brain and noone in their right mind should ever even dream of it.
There have been trials with lower ordered primates that have had success with this direct injection, but who in the world will shove a horse needle through their brain? Not me and really, knowing how some are, I should not even have mentioned it. Never the less it is what it is.
Loperamide is useless aside as its prescribed usage, as an anti-diahhreal and perhaps in the plcebo department for Acute W/D but a thinking person will never have that option knowing the relevant info beforehand.
Loperamide is a great lesson ins what is and what is not an opioid. Structure is not what determines a substance's classification and indeed Loperamide is structured very nicely. The problem though, and I will not bore folks with the chemistry is the substance's inability, EVER, to cross the Blood to Brain Barrier (BBB) UNLESS directed DIRECTLY into a person's brain and noone in their right mind should ever even dream of it.
There have been trials with lower ordered primates that have had success with this direct injection, but who in the world will shove a horse needle through their brain? Not me and really, knowing how some are, I should not even have mentioned it. Never the less it is what it is.
Loperamide is useless aside as its prescribed usage, as an anti-diahhreal and perhaps in the plcebo department for Acute W/D but a thinking person will never have that option knowing the relevant info beforehand.