arthunter888
Bluelighter
- Joined
- May 23, 2009
- Messages
- 623
^ What did you learn specifically?
Potency, is the strength per mg of a substance that is in the bloodstream.
Bio-availability determines the proportion of substance that makes it into the bloodstream when administered a certain way.
Therefore the overall effect that a given amount of substance has on the body is a combination of BA and potency.
When talking about JUST potency, one would have to IV the same amount of two different substances in order to compare, because it is consistently 100% BA regardless of individual, so BA is eliminated as a factor. This is why morphine is more potent than oxycodone, even though more morphine must be eaten than oxycodone for equal analgesia.
I think a term should be invented to distinguish between potency and overall effect (which needs BA as a variable). Maybe "bio-potency" would be a good term for relative over-all-effects of different drugs. e.g. "Oral oxycodone is more bio-potent than oral morphine."
Guys, we are all talking about the same thing here, right? Bioavailability and potency are extremely similar. For instance since Opana has only 10% BA and Oxys have around 85% (I'm only referring to orally) - in this example Oxycodone would be the stronger one, am I right? And yes I know that Opana is supposedly 4-5 times stronger in dose and analgesia but when taken orally it really doesn't do much. I know one of you is going to correct me but thats okay. It's what BL is here for!
^yeah, I wouldn't expect him to edit his post, but i don't think it is to be taken to0 seriously. i would say 4-5mg of intranasal opana off of a 40er is equal to about 20mg of oxycodone, and lasts several times longer than oxycodone. also, opana takes much longer to kick in than oxycodone, so careful about thinking you did not take enough and redosing too soon.
^^ You must be a very poor metabolizer (of opana). Keep in mind, ingesting opana with a full stomach (mainly high in fat) can nearly triple the BA. Therefore, try eating it after a filling, greasy meal. If fail, try snorting, also after a meal. You can't go wrong with this, but make sure you crush very thoroughly and divide your dose into many smaller lines to snort over 10-15 minutes, splitting between each nostril. This helps circumvent the effective anti-abuse gel.
Maybe there was something wrong with the pills...
whenever you took opana oraly and it didnt work AT ALL was it from the exact same source??? was it purchased from a dealer off the street???(or a friend, whoever, off the street is off the street)??? Because it could of been a bad batch, or fake pills. It hsa been known to happen.
And when you crushed up the opana pill and snorted it and it finally worked was that from the same source where you got the other ones??
All these things can make a difference.
But if it wasn't a problem with the pills....I would say its likely that you truly don't have the correct enzymes or whatever in your stomache that can properly break down opana so it can be metabolized.....this also isnt uncommon.
I personally do not have the right enzymes to break down alcohol...therefore whenever I drink I simply get horribly sick and throw up...well before I get any chance of being drunk....the doctors said it happens in one out of every like 30,000 people or something...
...so keeping that in mind...I can see how its possible that your missing an enzyme or for some reason arent able to break down opana to be properly metabolized.