Opioids Nubain Dose

[Dubby]

I have a slightly high tolerence to opiates, I take Hydrocodone daily and the occasional OP 80. I know that nalbuphine is an mu receptor antagonist, so I guess I have two questions. How long should i abstain from using hydros and oxys before taking nubain as to avoid any withdrawl effects? What is a good starting IV dose I have aquired some 20mg/ml amps.

 

[amapola]

I've never read about nalbuphine before. How it is notably more effective in females than males is pretty cool. Anyways a good rule for bupe is to wait until you are well within withdrawal before taking it to avoid precipitated withdrawal and I think this would be the same situation.

Latasch, Probst and Dudziak considered, in patients
who had received 7 p,g" kg -I fentanyl for induction of
anaesthesia and a further 200 p,g every 15 min, that the
narcosis would be reversed with 20 mg nalbuphine. 2
In that dose nalbuphine displaces fentanyl from mu
opioid receptors to facilitate breathing and a concomitant
lessening of mu antinociception. Kappa receptor moder-
ated analgesia may be obtained with larger doses of
nalbuphine (e.g., multiples of the 20 mg dose). Since
nalbuphine is a potent anaesthetic, 3 smaller doses, if
sufficient, should be acceptable in the recovery room.
http://www.springerlink.com/content/d30658j2r8394401/fulltext.pdf

The kappa makes me think it might not be that much fun unless you are actually taking it for paint relief.

edit: here's a thread on it from a couple years back. Nalbuphine/Nubain IM/IV question?

 

[Dubby]

Thanks for the info amapola

 

[oxynaut]

FYI nalbuphine is notorious for actually causing pain in males. the mechanism is not completely understood but be cautious. and in terms of waiting - the longer the better.... like with buprenorphine, introducing a partial agonist too soon can cause precip. w/d syndrome (AKA hell on earth) so be careful and patient

 

[Dubby]

man all this is makin me think about just giving these amps away

 

[bonebeater]

I used to take the nubain amps (SC usage) years ago. Not a very great feeling (mild by my current H standards) but it was the first hard code pain reliever I ever used recreationally. I found the effects wore off very quickly as well as quickly developing a tolerance. I tried upping the dose many times to about five or six vials in one go to try and improve the high - pretty much to no avail.