Just because an analogue can be tweaked doesn't mean it will be worth anything more than the differences in side effects. The benzo variations are a good example of differing length, amnesia, muscle relaxtion, inhibition and yet no real appreciably increased benzo effect. Fine enough for tuning patient effects, but not as catchy on the recreational side. One is def shopping for side effect differences. Its useful as another "rut breaker" for long termers trying to bridge maybe? Not real impressed.