Wizzle
Bluelighter
Why are you switching. And is there any reason beyond legality that you would choose methoxetamine over ketamine, memantine or dxm?
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N&PD Moderators: Skorpio | someguyontheinternet
NMDA antagonists for tolerance, a collection of the evidence and anecdotal reports
- Thread starter MeDieViL
- Start date
Wizzle
Bluelighter
Care to elaborate? I suppose I like the idea of ketamine and analogues because they are so effective as anti-depressants.. (and thus might do a better job at receptor upregulation). These are just ideas and not facts though.
avcpl
Bluelighter
MeDieViL, I'm still curious on your thoughts on DXM extended release (Delsym) or regular Hbr.
Is there any evidence that one is better than the other for tolerance reversal?
I was thinking the Hbr would be better since it might metabolize into DXO faster, which is apparently a much stronger antagonist. But I didn't know if there was evidence that steady plasma levels is better...
Is there any evidence that one is better than the other for tolerance reversal?
I was thinking the Hbr would be better since it might metabolize into DXO faster, which is apparently a much stronger antagonist. But I didn't know if there was evidence that steady plasma levels is better...
I'm not sure actually mate, both appear to work well.
Wizzle
Bluelighter
It seems that my methylphenidate is getting more effective.. I'm also noticing side effects like sweating a lot.. I'm gonna try a lower dose to see if that's effective.
I'm pretty excited about the results, too bad about sides being more pronounced but that's how they were in the beginning so it was to be expected.
I'm pretty excited about the results, too bad about sides being more pronounced but that's how they were in the beginning so it was to be expected.
Its more complex then that, ADHD is mostly hypofunctioning of the prefrontal cortex, increased dopamine levels induced by stimulants counteract that by activating the D4 receptors, D4 doesnt downregulate however its the other receptors implicated in euphoria and the other effects of stimulants, because D4 doesnt downregulate tolerance in most cases to the anti ADHD effects doesnt occur.
However hypofunctioning of the other receptors can also cause ADHD symptons, wich is why some individuals with ADHD do build a tolerance rapidly.
To answer your original question, yup but it does a shitload more too, allmost all the damn dopamine receptors are located in the striatum.
Some ppl may benefit best from NMDA agonists combined with therapy yes, but as with all mental disorders i beleive they can be caused both by passed events, or learned fear and also hypofunctioning, simular to something we see in ADHD, if in your case the last thing is the case, i see nothing wrong with this treatment.
Thanks for the reply. I see nothing wrong with the treatment either except the cost. Opiates on the street are expensive except for heroin. I need to know what dose I'm taking though. I have asperger's syndrome which has a high rate of co-morbid anxiety disorders. From my memory, I've been anxious my whole life. It certainly has something to do with my neurochemical balance.
I'm about to try kratom. It's a mu agonist and delta agonist. Delta agonists seem to have antidepressant and anxiolytic effects at least in studies. Maybe in combination with a NMDA antagonist, It could be a long term cheap solution. I really wish the medical establishment would consider opiates in refractory cases. The other antidepressants seem to have no primary effects and nasty w/d effects to add insult to injury.
This may sound like a crazy idea.
But in case i would want to get some human study's started showing the effiacy of NMDA antagonists against tolerance, what would i need to do?
Looking at the potential its damn worth investing in this! Just need to find the right people haha.
But in case i would want to get some human study's started showing the effiacy of NMDA antagonists against tolerance, what would i need to do?
Looking at the potential its damn worth investing in this! Just need to find the right people haha.
Wizzle
Bluelighter
maybe contact PsyQ in the hague.. They do a lot of work on adhd and addiction. Doing a trial with adhd-outpatients on medication effectiveness after a set amount of weeks with and without nmda-antagonists should be fairly easy and cheap to set up right?
Wizzle
Bluelighter
Graag gedaan! Het lijkt me geweldig als er wat van komt, hier moet echt iets mee gedaan worden!
Been taking low doses of mxe every 3 hours but it seems to inhibit the dopaminergic effects of the low daily doses of AMT i take (7,5mg) now it feels like a day long dose of mdai wich makes me damn tired, been sleeping most of the time the last 2 days lol, mdai is way to sedating on its own for me too.
Depressicaa
Bluelighter
Memantine is a great tolerance reducer.
3 days of low DXM? Why not just one day of high DXM (P3)? It worked right after in my experience. I dunno what your body weight is and what a low dose to you is either.
3 days of low DXM? Why not just one day of high DXM (P3)? It worked right after in my experience. I dunno what your body weight is and what a low dose to you is either.