• Neuroscience & Pharmacology Discussion Welcome Guest
    Posting Rules Bluelight Rules
    Recent Journal Articles Chemistry Mega-Thread
    FREE Chemistry Databases! Self-Education Guide

  • N&PD Moderators: Skorpio

NMDA antagonists for tolerance, a collection of the evidence and anecdotal reports

Why are you switching. And is there any reason beyond legality that you would choose methoxetamine over ketamine, memantine or dxm?
 
Ive been out of memantine for a while now due to lack of funds, should get it again in the future tough, MXE seems the most interesting of the others, cant take DXM as i take AMT daily.
 
Care to elaborate? I suppose I like the idea of ketamine and analogues because they are so effective as anti-depressants.. (and thus might do a better job at receptor upregulation). These are just ideas and not facts though.
 
MeDieViL, I'm still curious on your thoughts on DXM extended release (Delsym) or regular Hbr.

Is there any evidence that one is better than the other for tolerance reversal?

I was thinking the Hbr would be better since it might metabolize into DXO faster, which is apparently a much stronger antagonist. But I didn't know if there was evidence that steady plasma levels is better...
 
avcpl said:
MeDieViL, I'm still curious on your thoughts on DXM extended release (Delsym) or regular Hbr.

Is there any evidence that one is better than the other for tolerance reversal?

I was thinking the Hbr would be better since it might metabolize into DXO faster, which is apparently a much stronger antagonist. But I didn't know if there was evidence that steady plasma levels is better...
Click to expand...

I'm not sure actually mate, both appear to work well.
 
It seems that my methylphenidate is getting more effective.. I'm also noticing side effects like sweating a lot.. I'm gonna try a lower dose to see if that's effective.

I'm pretty excited about the results, too bad about sides being more pronounced but that's how they were in the beginning so it was to be expected.
 
Wizzle said:
Right, and the striatum is hypothesized to be involved in sustained and selective attention right?
Click to expand...

Its more complex then that, ADHD is mostly hypofunctioning of the prefrontal cortex, increased dopamine levels induced by stimulants counteract that by activating the D4 receptors, D4 doesnt downregulate however its the other receptors implicated in euphoria and the other effects of stimulants, because D4 doesnt downregulate tolerance in most cases to the anti ADHD effects doesnt occur.

However hypofunctioning of the other receptors can also cause ADHD symptons, wich is why some individuals with ADHD do build a tolerance rapidly.

To answer your original question, yup but it does a shitload more too, allmost all the damn dopamine receptors are located in the striatum.
 
ferinox said:
I'm pretty sure I remember reading that glutamate is heavily involved in fear extinction so maybe it's not a good treatment for anxiety. I still use opiates in combination with dxm to allow self medication with less unfortunate effects like tolerance and heavy dependence. Nothing treats my anxiety and depression so effectively. Eventually if I want my life to go anywhere, I might have to reconsider this method of treatment. If only I had adequate money, I could medicate and go to college.
Click to expand...

Some ppl may benefit best from NMDA agonists combined with therapy yes, but as with all mental disorders i beleive they can be caused both by passed events, or learned fear and also hypofunctioning, simular to something we see in ADHD, if in your case the last thing is the case, i see nothing wrong with this treatment.
 
MeDieViL said:
Some ppl may benefit best from NMDA agonists combined with therapy yes, but as with all mental disorders i beleive they can be caused both by passed events, or learned fear and also hypofunctioning, simular to something we see in ADHD, if in your case the last thing is the case, i see nothing wrong with this treatment.
Click to expand...

Thanks for the reply. I see nothing wrong with the treatment either except the cost. Opiates on the street are expensive except for heroin. I need to know what dose I'm taking though. I have asperger's syndrome which has a high rate of co-morbid anxiety disorders. From my memory, I've been anxious my whole life. It certainly has something to do with my neurochemical balance.

I'm about to try kratom. It's a mu agonist and delta agonist. Delta agonists seem to have antidepressant and anxiolytic effects at least in studies. Maybe in combination with a NMDA antagonist, It could be a long term cheap solution. I really wish the medical establishment would consider opiates in refractory cases. The other antidepressants seem to have no primary effects and nasty w/d effects to add insult to injury.
 
I'm only starting to realize how godamn powerful DXM can really be when it comes to tolerance. Details will follow...
 
This may sound like a crazy idea.

But in case i would want to get some human study's started showing the effiacy of NMDA antagonists against tolerance, what would i need to do?

Looking at the potential its damn worth investing in this! Just need to find the right people haha.
 
maybe contact PsyQ in the hague.. They do a lot of work on adhd and addiction. Doing a trial with adhd-outpatients on medication effectiveness after a set amount of weeks with and without nmda-antagonists should be fairly easy and cheap to set up right?
 
Been taking low doses of mxe every 3 hours but it seems to inhibit the dopaminergic effects of the low daily doses of AMT i take (7,5mg) now it feels like a day long dose of mdai wich makes me damn tired, been sleeping most of the time the last 2 days lol, mdai is way to sedating on its own for me too.
 
Gonna try 600mg DXM in the form of robitussin later. See if Alpraz tolerance is lowered tomorrow
 
This is really great thread! For how long does one have to take small doses of dxm to lower the tollerance?Would be lets say 3 days prior to stimulant consumption enough? Cheers.
 
Memantine is a great tolerance reducer.

3 days of low DXM? Why not just one day of high DXM (P3)? It worked right after in my experience. I dunno what your body weight is and what a low dose to you is either.
 
You must log in or register to reply here.
Top