monstanoodle
Bluelight Crew
Don't inject Codeine in any manner!
You'll end up with a massive, and potentially very very nasty Histamine release (and no, it wouldn't help if you took an Antihistamine at all).
As for plugging it, it needs a couple of your Liver's enzymes to actually have an effect: Here's comes a boring but interesting to me part:
~10% of Codeine is converted to Morphine - for those who have a fully functioning CYP2D6 enzyme production going on (this is phase 1 of metabolism).
And CYP3A4 converts some of the Codeine to Norcodeine, then UGT2B7 converts Codeine, Morphine and Norcodeine into Codeine-3-Glucuronide [C3G, Codeine-6-glucuronide [C6G], Morphine-3-Glucuronide [M3G] and Morphine-6-Glucuronide [M6G] (Phase 2).
There's dispute as to how much analgesic (and other) effects each of these metabolites have on the body but me, and I think remember Shambles, chatting about C6G's effects being drastically understated, because the Morphine content that's produced has not much effect considering the effect that Codeine has as a whole.
When it comes to DHC, I would say the same when it comes to injecting, but I know less about that aside that it goes through the same metabolic stages but is more powerful when it comes to it's analgesic properties. Plus some find it more euphoric and lush and what and not
Oh, and if you wish for your prescription to be upped, then I'd suggest saying that "It does have an effect on the pain, but it's very small... Could the dose be upped?" instead of saying "It's not working" because then they'll likely stick you with some more NSAID's and stuff, which (from experience) can give yer stomach some painful grief 8(
You'll end up with a massive, and potentially very very nasty Histamine release (and no, it wouldn't help if you took an Antihistamine at all).
As for plugging it, it needs a couple of your Liver's enzymes to actually have an effect: Here's comes a boring but interesting to me part:
~10% of Codeine is converted to Morphine - for those who have a fully functioning CYP2D6 enzyme production going on (this is phase 1 of metabolism).
And CYP3A4 converts some of the Codeine to Norcodeine, then UGT2B7 converts Codeine, Morphine and Norcodeine into Codeine-3-Glucuronide [C3G, Codeine-6-glucuronide [C6G], Morphine-3-Glucuronide [M3G] and Morphine-6-Glucuronide [M6G] (Phase 2).
There's dispute as to how much analgesic (and other) effects each of these metabolites have on the body but me, and I think remember Shambles, chatting about C6G's effects being drastically understated, because the Morphine content that's produced has not much effect considering the effect that Codeine has as a whole.
When it comes to DHC, I would say the same when it comes to injecting, but I know less about that aside that it goes through the same metabolic stages but is more powerful when it comes to it's analgesic properties. Plus some find it more euphoric and lush and what and not

Oh, and if you wish for your prescription to be upped, then I'd suggest saying that "It does have an effect on the pain, but it's very small... Could the dose be upped?" instead of saying "It's not working" because then they'll likely stick you with some more NSAID's and stuff, which (from experience) can give yer stomach some painful grief 8(